TITINdb

Map SAVs to Structure

The data displayed in the table aims to be as complete as possible and contains information for all available sources including different versions of the same source, for example, different sources of gnomAD. To avoid seeing multiple entries for the same variant, we recommend to sort by Source first.

Position	Domain position	SAV	Structural Position	RS	Q(SASA)	Disease	Source	MAF
8549	1	P/H	1	rs774351461	0.2097	None	gnomAD-2.1.1	5.34E-05
8549	1	P/H	1	rs774351461	0.2097	None	gnomAD-3.1.2	2.63E-05
8549	1	P/H	1	rs774351461	0.2097	None	gnomAD-4.0.0	8.6227E-05
8549	1	P/L	1	None	0.2097	None	gnomAD-4.0.0	1.40334E-06
8549	1	P/S	1	rs536374359	0.2097	None	gnomAD-2.1.1	3.66E-05
8549	1	P/S	1	rs536374359	0.2097	None	gnomAD-3.1.2	2.63E-05
8549	1	P/S	1	rs536374359	0.2097	None	1000 genomes	1.99681E-04
8549	1	P/S	1	rs536374359	0.2097	None	gnomAD-4.0.0	2.34722E-05
8550	2	R/G	2	rs371161599	0.5082	None	gnomAD-2.1.1	1.55E-05
8550	2	R/G	2	rs371161599	0.5082	None	gnomAD-4.0.0	5.61101E-06
8550	2	R/M	2	None	0.5082	None	gnomAD-4.0.0	7.01471E-07
8550	2	R/S	2	rs2077385819	0.5082	None	gnomAD-4.0.0	8.40998E-06
8552	4	I/T	4	rs940884256	0.4675	None	gnomAD-2.1.1	5E-06
8552	4	I/T	4	rs940884256	0.4675	None	gnomAD-3.1.2	1.97E-05
8552	4	I/T	4	rs940884256	0.4675	None	gnomAD-4.0.0	5.05384E-06
8554	6	K/E	7	rs201945791	0.6609	None	gnomAD-2.1.1	1.15357E-04
8554	6	K/E	7	rs201945791	0.6609	None	gnomAD-3.1.2	1.11732E-04
8554	6	K/E	7	rs201945791	0.6609	None	gnomAD-4.0.0	8.32718E-05
8554	6	K/N	7	rs568546539	0.6609	None	gnomAD-2.1.1	4.92E-05
8554	6	K/N	7	rs568546539	0.6609	None	gnomAD-3.1.2	1.97E-05
8554	6	K/N	7	rs568546539	0.6609	None	1000 genomes	3.99361E-04
8554	6	K/N	7	rs568546539	0.6609	None	gnomAD-4.0.0	1.26109E-05
8555	7	L/Q	8	None	0.1822	None	gnomAD-4.0.0	6.96823E-07
8556	8	E/D	9	None	0.6425	None	gnomAD-4.0.0	3.31776E-06
8557	9	P/T	11	None	0.7295	None	gnomAD-4.0.0	1.65379E-06
8559	11	R/K	14	rs745818225	0.2426	None	gnomAD-2.1.1	4.72E-06
8559	11	R/K	14	rs745818225	0.2426	None	gnomAD-4.0.0	2.08309E-06
8560	12	I/T	16	rs727504204	0.6596	None	gnomAD-4.0.0	1.38592E-06
8561	13	V/L	17	None	0.1836	None	gnomAD-4.0.0	6.92609E-07
8561	13	V/M	17	None	0.1836	None	gnomAD-4.0.0	6.23348E-06
8563	15	Q/E	23	None	0.4026	None	gnomAD-4.0.0	2.76474E-06
8564	16	D/G	24	rs770623711	0.5978	None	gnomAD-2.1.1	8.91E-06
8564	16	D/G	24	rs770623711	0.5978	None	gnomAD-4.0.0	2.07109E-06
8567	19	T/A	28	rs777832511	0.1623	None	gnomAD-2.1.1	4.34E-06
8567	19	T/A	28	rs777832511	0.1623	None	gnomAD-3.1.2	1.97E-05
8567	19	T/A	28	rs777832511	0.1623	None	gnomAD-4.0.0	6.2339E-06
8567	19	T/K	28	rs867794054	0.1623	None	gnomAD-4.0.0	1.61538E-06
8567	19	T/P	28	rs777832511	0.1623	None	gnomAD-2.1.1	4.34E-06
8567	19	T/P	28	rs777832511	0.1623	None	gnomAD-3.1.2	6.57E-06
8567	19	T/P	28	rs777832511	0.1623	None	gnomAD-4.0.0	6.57263E-06
8568	20	R/M	29	None	0.2730	None	gnomAD-4.0.0	1.61428E-06
8568	20	R/S	29	None	0.2730	None	gnomAD-4.0.0	6.88015E-07
8570	22	E/K	31	rs552462622	0.3221	None	gnomAD-2.1.1	4.12E-05
8570	22	E/K	31	rs552462622	0.3221	None	gnomAD-3.1.2	7.23E-05
8570	22	E/K	31	rs552462622	0.3221	None	1000 genomes	1.99681E-04
8570	22	E/K	31	rs552462622	0.3221	None	gnomAD-4.0.0	1.44985E-04
8573	25	I/L	35	rs142609645	0.1131	None	gnomAD-2.1.1	1.1E-05
8573	25	I/L	35	rs142609645	0.1131	None	gnomAD-3.1.2	7.23E-05
8573	25	I/L	35	rs142609645	0.1131	None	1000 genomes	1.99681E-04
8573	25	I/L	35	rs142609645	0.1131	None	gnomAD-4.0.0	8.07615E-06
8574	26	G/D	38	None	0.2452	None	gnomAD-4.0.0	6.85839E-07
8574	26	G/R	38	None	0.2452	None	gnomAD-4.0.0	6.85979E-07
8574	26	G/S	38	rs752013701	0.2452	None	gnomAD-2.1.1	1.83E-05
8574	26	G/S	38	rs752013701	0.2452	None	gnomAD-3.1.2	3.29E-05
8574	26	G/S	38	rs752013701	0.2452	None	gnomAD-4.0.0	5.59085E-06
8575	27	G/E	40	None	0.4817	None	gnomAD-4.0.0	1.59856E-06
8575	27	G/R	40	rs397517517	0.4817	None	gnomAD-2.1.1	8.25E-06
8575	27	G/R	40	rs397517517	0.4817	None	gnomAD-3.1.2	1.97E-05
8575	27	G/R	40	rs397517517	0.4817	None	gnomAD-4.0.0	9.93517E-06
8576	28	S/F	41	rs376095355	0.7458	None	gnomAD-2.1.1	8.2E-06
8576	28	S/F	41	rs376095355	0.7458	None	gnomAD-4.0.0	1.16503E-05
8576	28	S/P	41	rs1176708240	0.7458	None	gnomAD-2.1.1	4.11E-06
8576	28	S/P	41	rs1176708240	0.7458	None	gnomAD-3.1.2	6.58E-06
8576	28	S/P	41	rs1176708240	0.7458	None	gnomAD-4.0.0	6.42695E-06
8577	29	P/T	42	None	0.5536	None	gnomAD-4.0.0	1.59731E-06
8579	31	I/F	44	None	0.1699	None	gnomAD-4.0.0	6.84841E-07
8579	31	I/V	44	None	0.1699	None	gnomAD-4.0.0	1.36968E-06
8580	32	K/R	45	None	0.6621	None	gnomAD-4.0.0	1.59385E-06
8581	33	V/F	46	None	0.2361	None	gnomAD-4.0.0	6.84702E-07
8581	33	V/I	46	rs1014791707	0.2361	None	gnomAD-4.0.0	3.42351E-06
8581	33	V/L	46	rs1014791707	0.2361	None	gnomAD-2.1.1	4.06E-06
8581	33	V/L	46	rs1014791707	0.2361	None	gnomAD-4.0.0	1.36941E-06
8582	34	L/S	47	None	0.3679	None	gnomAD-4.0.0	1.20032E-06
8582	34	L/V	47	rs1420202972	0.3679	None	gnomAD-2.1.1	7.18E-06
8582	34	L/V	47	rs1420202972	0.3679	None	gnomAD-3.1.2	6.58E-06
8582	34	L/V	47	rs1420202972	0.3679	None	gnomAD-4.0.0	2.56512E-06
8583	35	W/R	48	None	0.1471	None	gnomAD-4.0.0	2.05362E-06
8584	36	Y/C	49	rs1440957407	0.2160	None	gnomAD-2.1.1	3.18E-05
8584	36	Y/C	49	rs1440957407	0.2160	None	gnomAD-3.1.2	1.31E-05
8584	36	Y/C	49	rs1440957407	0.2160	None	gnomAD-4.0.0	1.3146E-05
8584	36	Y/H	49	None	0.2160	None	gnomAD-4.0.0	1.20032E-06
8586	38	D/N	51	rs1199035064	0.4219	None	gnomAD-2.1.1	4.03E-06
8586	38	D/N	51	rs1199035064	0.4219	None	gnomAD-4.0.0	3.42209E-06
8586	38	D/V	51	rs1484446680	0.4219	None	gnomAD-2.1.1	4.03E-06
8586	38	D/V	51	rs1484446680	0.4219	None	gnomAD-4.0.0	1.5924E-06
8587	39	E/D	52	rs2077371991	0.7746	None	gnomAD-4.0.0	1.59227E-06
8587	39	E/K	52	rs760340908	0.7746	None	gnomAD-2.1.1	8.07E-06
8587	39	E/K	52	rs760340908	0.7746	None	gnomAD-4.0.0	1.09508E-05
8587	39	E/Q	52	rs760340908	0.7746	None	gnomAD-2.1.1	4.03E-06
8587	39	E/Q	52	rs760340908	0.7746	None	gnomAD-3.1.2	6.58E-06
8587	39	E/Q	52	rs760340908	0.7746	None	gnomAD-4.0.0	6.57609E-06
8593	45	S/R	73	rs560562125	0.2341	None	gnomAD-2.1.1	4.02E-06
8593	45	S/R	73	rs560562125	0.2341	None	gnomAD-3.1.2	6.58E-06
8593	45	S/R	73	rs560562125	0.2341	None	1000 genomes	1.99681E-04
8593	45	S/R	73	rs560562125	0.2341	None	gnomAD-4.0.0	6.57255E-06
8594	46	S/G	111	None	0.7302	None	gnomAD-4.0.0	2.40064E-06
8594	46	S/N	111	rs759108676	0.7302	None	gnomAD-2.1.1	4.02E-06
8594	46	S/N	111	rs759108676	0.7302	None	gnomAD-4.0.0	1.20032E-06
8594	46	S/R	111	None	0.7302	None	gnomAD-4.0.0	6.84299E-07
8595	47	K/N	115	None	0.1958	None	gnomAD-4.0.0	1.59172E-06
8595	47	K/Q	115	None	0.1958	None	gnomAD-4.0.0	1.36859E-06
8595	47	K/R	115	rs774140425	0.1958	None	gnomAD-2.1.1	2.01E-05
8595	47	K/R	115	rs774140425	0.1958	None	gnomAD-3.1.2	6.57E-06
8595	47	K/R	115	rs774140425	0.1958	None	gnomAD-4.0.0	1.66584E-05
8598	50	M/I	123	rs770947302	0.2153	None	gnomAD-2.1.1	1.21E-05
8598	50	M/I	123	rs770947302	0.2153	None	gnomAD-4.0.0	3.18338E-06
8598	50	M/T	123	None	0.2153	None	gnomAD-4.0.0	1.20032E-06
8598	50	M/V	123	rs1180662147	0.2153	None	gnomAD-3.1.2	6.57E-06
8598	50	M/V	123	rs1180662147	0.2153	None	gnomAD-4.0.0	6.57393E-06
8600	52	F/L	127	None	0.3319	None	gnomAD-4.0.0	1.59164E-06
8600	52	F/Y	127	None	0.3319	None	gnomAD-4.0.0	1.20032E-06
8601	53	V/F	130	rs184812963	0.6599	None	gnomAD-2.1.1	5E-05
8601	53	V/F	130	rs184812963	0.6599	None	gnomAD-3.1.2	1.97E-05
8601	53	V/F	130	rs184812963	0.6599	None	1000 genomes	1.99681E-04
8601	53	V/F	130	rs184812963	0.6599	None	gnomAD-4.0.0	1.42535E-05
8601	53	V/I	130	rs184812963	0.6599	None	gnomAD-2.1.1	4.02E-06
8601	53	V/I	130	rs184812963	0.6599	None	gnomAD-4.0.0	5.47425E-06
8602	54	D/E	131	None	0.9060	None	gnomAD-4.0.0	6.84271E-07
8603	55	S/L	134	rs781354478	0.3473	None	gnomAD-2.1.1	1.21E-05
8603	55	S/L	134	rs781354478	0.3473	None	gnomAD-3.1.2	1.32E-05
8603	55	S/L	134	rs781354478	0.3473	None	gnomAD-4.0.0	6.81796E-06
8603	55	S/P	134	rs748398405	0.3473	None	gnomAD-2.1.1	4.02E-06
8603	55	S/P	134	rs748398405	0.3473	None	gnomAD-3.1.2	6.57E-06
8603	55	S/P	134	rs748398405	0.3473	None	gnomAD-4.0.0	6.57324E-06
8603	55	S/W	134	None	0.3473	None	gnomAD-4.0.0	6.84275E-07
8604	56	V/A	135	None	0.2274	None	gnomAD-4.0.0	1.59158E-06
8604	56	V/M	135	rs1160730554	0.2274	None	gnomAD-2.1.1	4.02E-06
8604	56	V/M	135	rs1160730554	0.2274	None	gnomAD-4.0.0	1.59157E-06
8605	57	A/T	136	None	0.0914	None	gnomAD-4.0.0	1.59158E-06
8606	58	V/G	137	rs747173071	0.1386	None	gnomAD-2.1.1	8.04E-06
8606	58	V/G	137	rs747173071	0.1386	None	gnomAD-4.0.0	1.59157E-06
8606	58	V/L	137	None	0.1386	None	gnomAD-4.0.0	6.84269E-07
8606	58	V/M	137	rs1453874617	0.1386	None	gnomAD-2.1.1	4.02E-06
8606	58	V/M	137	rs1453874617	0.1386	None	gnomAD-4.0.0	6.84269E-07
8607	59	L/P	138	rs780404365	0.0723	None	gnomAD-2.1.1	4.02E-06
8607	59	L/R	138	None	0.0723	None	gnomAD-4.0.0	1.59155E-06
8608	60	E/A	139	None	0.2570	None	gnomAD-4.0.0	6.84262E-07
8608	60	E/G	139	None	0.2570	None	gnomAD-4.0.0	6.84262E-07
8609	61	M/I	140	rs1407524421	0.0744	None	gnomAD-4.0.0	2.05282E-06
8609	61	M/V	140	rs1369418506	0.0744	None	gnomAD-3.1.2	6.57E-06
8609	61	M/V	140	rs1369418506	0.0744	None	gnomAD-4.0.0	6.57445E-06
8610	62	H/P	141	None	0.2877	None	gnomAD-4.0.0	6.84261E-07
8610	62	H/Q	141	rs200939405	0.2877	None	gnomAD-2.1.1	3.21E-05
8610	62	H/Q	141	rs200939405	0.2877	None	gnomAD-3.1.2	5.92E-05
8610	62	H/Q	141	rs200939405	0.2877	None	gnomAD-4.0.0	8.67733E-06
8610	62	H/R	141	rs561059250	0.2877	None	gnomAD-2.1.1	3.57E-05
8610	62	H/R	141	rs561059250	0.2877	None	gnomAD-3.1.2	3.29E-05
8610	62	H/R	141	rs561059250	0.2877	None	1000 genomes	1.99681E-04
8610	62	H/R	141	rs561059250	0.2877	None	gnomAD-4.0.0	1.98311E-05
8611	63	N/K	143	None	0.7793	None	gnomAD-4.0.0	1.20032E-06
8611	63	N/S	143	rs779262321	0.7793	None	gnomAD-2.1.1	1.21E-05
8611	63	N/S	143	rs779262321	0.7793	None	gnomAD-3.1.2	6.58E-06
8611	63	N/S	143	rs779262321	0.7793	None	gnomAD-4.0.0	2.16925E-05
8612	64	L/F	144	rs755695660	0.1135	None	gnomAD-2.1.1	4.02E-06
8612	64	L/F	144	rs755695660	0.1135	None	gnomAD-3.1.2	6.58E-06
8612	64	L/F	144	rs755695660	0.1135	None	gnomAD-4.0.0	1.85944E-06
8612	64	L/R	144	rs1345942434	0.1135	None	gnomAD-3.1.2	6.58E-06
8612	64	L/R	144	rs1345942434	0.1135	None	gnomAD-4.0.0	6.58155E-06
8613	65	S/R	145	None	0.1551	None	gnomAD-4.0.0	6.84264E-07
8614	66	V/A	146	None	0.5102	None	gnomAD-4.0.0	1.59153E-06
8615	67	E/D	148	rs758944073	0.4075	None	gnomAD-2.1.1	4.02E-06
8615	67	E/D	148	rs758944073	0.4075	None	gnomAD-4.0.0	6.84269E-07
8617	69	S/I	151	None	0.2064	None	gnomAD-4.0.0	1.5916E-06
8617	69	S/N	151	rs1361559046	0.2064	None	gnomAD-2.1.1	8.05E-06
8617	69	S/N	151	rs1361559046	0.2064	None	gnomAD-4.0.0	6.36641E-06
8618	70	G/E	152	rs369947439	0.1662	None	gnomAD-2.1.1	4.42E-05
8618	70	G/E	152	rs369947439	0.1662	None	gnomAD-3.1.2	6.58E-05
8618	70	G/E	152	rs369947439	0.1662	None	gnomAD-4.0.0	4.89647E-05
8619	71	D/G	153	rs2077359221	0.5818	None	gnomAD-4.0.0	4.10566E-06
8620	72	Y/C	154	None	0.1129	None	gnomAD-4.0.0	1.59163E-06
8621	73	T/I	155	None	0.2119	None	gnomAD-4.0.0	6.84286E-07
8621	73	T/N	155	rs899151063	0.2119	None	gnomAD-2.1.1	8.05E-06
8621	73	T/N	155	rs899151063	0.2119	None	gnomAD-3.1.2	6.57E-06
8621	73	T/N	155	rs899151063	0.2119	None	gnomAD-4.0.0	4.33843E-06
8622	74	C/Y	156	None	0.0686	None	gnomAD-4.0.0	1.59168E-06
8623	75	E/D	157	None	0.3260	None	gnomAD-4.0.0	1.36861E-06
8623	75	E/G	157	rs766190373	0.3260	None	gnomAD-2.1.1	4.02E-06
8626	78	N/D	161	rs2077357318	0.1657	None	gnomAD-3.1.2	6.57E-06
8626	78	N/D	161	rs2077357318	0.1657	None	gnomAD-4.0.0	6.57177E-06
8626	78	N/S	161	rs200355367	0.1657	None	gnomAD-2.1.1	1.21503E-04
8626	78	N/S	161	rs200355367	0.1657	None	gnomAD-3.1.2	1.70882E-04
8626	78	N/S	161	rs200355367	0.1657	None	gnomAD-4.0.0	3.26633E-04
8627	79	A/V	162	rs1349154909	0.7380	None	gnomAD-2.1.1	3.19E-05
8627	79	A/V	162	rs1349154909	0.7380	None	gnomAD-3.1.2	6.57E-06
8627	79	A/V	162	rs1349154909	0.7380	None	gnomAD-4.0.0	2.02993E-06
8628	80	A/V	163	None	0.7239	None	gnomAD-4.0.0	1.59257E-06
8629	81	G/S	164	rs2077356013	0.3170	None	gnomAD-3.1.2	6.57E-06
8629	81	G/S	164	rs2077356013	0.3170	None	gnomAD-4.0.0	6.57479E-06
8629	81	G/V	164	None	0.3170	None	gnomAD-4.0.0	1.59355E-06
8630	82	S/C	165	None	0.5445	None	gnomAD-4.0.0	1.20032E-06
8631	83	A/T	166	rs769720173	0.2198	None	gnomAD-2.1.1	2.42E-05
8631	83	A/T	166	rs769720173	0.2198	None	gnomAD-3.1.2	6.57E-06
8631	83	A/T	166	rs769720173	0.2198	None	gnomAD-4.0.0	8.98124E-06
8632	84	S/G	168	None	0.4102	None	gnomAD-4.0.0	2.40064E-06
8633	85	S/G	169	rs776980958	0.1218	None	gnomAD-2.1.1	4.03E-06
8633	85	S/G	169	rs776980958	0.1218	None	gnomAD-4.0.0	1.59484E-06
8634	86	S/C	171	rs769050572	0.3693	None	gnomAD-2.1.1	1.21E-05
8634	86	S/C	171	rs769050572	0.3693	None	gnomAD-3.1.2	6.57E-06
8634	86	S/C	171	rs769050572	0.3693	None	gnomAD-4.0.0	3.10148E-06
8635	87	T/A	172	None	0.1054	None	gnomAD-4.0.0	1.20039E-06
8635	87	T/I	172	rs1005082166	0.1054	None	gnomAD-3.1.2	6.57E-06
8635	87	T/I	172	rs1005082166	0.1054	None	gnomAD-4.0.0	1.24085E-06
8636	88	S/A	173	rs1448059327	0.2637	None	gnomAD-2.1.1	4.04E-06
8636	88	S/A	173	rs1448059327	0.2637	None	gnomAD-4.0.0	1.59608E-06
8636	88	S/T	173	rs1448059327	0.2637	None	gnomAD-2.1.1	3.19E-05
8636	88	S/T	173	rs1448059327	0.2637	None	gnomAD-3.1.2	6.57E-06
8636	88	S/T	173	rs1448059327	0.2637	None	gnomAD-4.0.0	3.85262E-06
8638	90	K/N	175	None	0.6783	None	gnomAD-4.0.0	1.59765E-06
8639	91	V/I	177	rs1427227571	0.1162	None	gnomAD-2.1.1	4.05E-06
8639	91	V/I	177	rs1427227571	0.1162	None	gnomAD-4.0.0	1.371E-06

Position	Domain position	SAV	RS	Q(SASA)	Source	Structural Position	Disease	AlphaMissense (IC)	AlphaMissense (N2AB)	CADD	Condel	DUET	FATHMM	M-CAP	mCSM	MetaLR	MetaSVM	MPC	MutationAssessor	MutationTaster	MutPred	MVP	PolyPhen-2	PrimateAI	PROVEAN	REVEL	Rhapsody	SIFT	Zygosity	Comments	MAF	AFR	AMR	AMS	ASJ	EAS	EUR	FIN	MDE	NFE	SAS	OTH	Site Annotation	Predicted PPI	mCSM-PPI
8549	1	P/H	rs774351461	0.2097	gnomAD-2.1.1	1	None	0.9961	0.9954	27.3	D	-1.608	-1.45	0.152567	-1.389	0.8291	0.9628	0.49825478594	None	0.998462	0.747	0.877040243179	1.0	0.632360875607	-5.59	0.83	0.879	0.009	None	None	5.34E-05	0	0	0	0	None	0	None	5.34E-05	0	1.13999E-04	1.62813E-04	None	N	None
8549	1	P/H	rs774351461	0.2097	gnomAD-3.1.2	1	None	0.9961	0.9954	27.3	D	-1.608	-1.45	0.152567	-1.389	0.8291	0.9628	0.49825478594	None	0.998462	0.747	0.877040243179	1.0	0.632360875607	-5.59	0.83	0.879	0.009	None	None	2.63E-05	2.42E-05	0	0	0	None	0	0	2.63E-05	4.41E-05	0	0	None	N	None
8549	1	P/H	rs774351461	0.2097	gnomAD-4.0.0	1	None	0.9961	0.9954	27.3	D	-1.608	-1.45	0.152567	-1.389	0.8291	0.9628	0.49825478594	None	0.998462	0.747	0.877040243179	1.0	0.632360875607	-5.59	0.83	0.879	0.009	None	None	8.6227E-05	5.40205E-05	1.83043E-05	0	0	None	0	0	8.6227E-05	1.07783E-04	0	9.82157E-05	None	N	None
8549	1	P/L	None	0.2097	gnomAD-4.0.0	1	None	0.8838	0.8809	27.7	D	None	-1.44	0.072308	-0.829	0.8104	0.8997	0.469722267271	None	0.999996	0.795	0.917192438884	1.0	0.651052951813	-6.03	0.852	0.911	0.01	None	None	1.40334E-06	0	0	0	0	None	3.9142E-05	0	1.40334E-06	0	0	0	None	N	None
8549	1	P/S	rs536374359	0.2097	gnomAD-2.1.1	1	None	0.9564	0.9495	24.9	D	-1.616	-1.43	0.087068	-1.656	0.7971	0.8516	0.466644225527	None	0.997949	0.75	0.686436817987	1.0	0.584340214729	-4.75	0.853	0.907	0.024	None	None	3.66E-05	0	0	0	4.97937E-04	None	0	None	3.66E-05	0	0	0	None	N	None
8549	1	P/S	rs536374359	0.2097	gnomAD-3.1.2	1	None	0.9564	0.9495	24.9	D	-1.616	-1.43	0.087068	-1.656	0.7971	0.8516	0.466644225527	None	0.997949	0.75	0.686436817987	1.0	0.584340214729	-4.75	0.853	0.907	0.024	None	None	2.63E-05	0	0	0	5.78258E-04	None	0	0	2.63E-05	0	0	4.78011E-04	None	N	None
8549	1	P/S	rs536374359	0.2097	1000 genomes	1	None	0.9564	0.9495	24.9	D	-1.616	-1.43	0.087068	-1.656	0.7971	0.8516	0.466644225527	None	0.997949	0.75	0.686436817987	1.0	0.584340214729	-4.75	0.853	0.907	0.024	None	None	1.99681E-04	0	0	None	1E-03	0	None	None	1.99681E-04	None	0	None	None	N	None
8549	1	P/S	rs536374359	0.2097	gnomAD-4.0.0	1	None	0.9564	0.9495	24.9	D	-1.616	-1.43	0.087068	-1.656	0.7971	0.8516	0.466644225527	None	0.997949	0.75	0.686436817987	1.0	0.584340214729	-4.75	0.853	0.907	0.024	None	None	2.34722E-05	0	0	0	8.28424E-04	None	0	0	2.34722E-05	0	0	1.63736E-05	None	N	None
8550	2	R/G	rs371161599	0.5082	gnomAD-2.1.1	2	None	0.423	0.4268	None	N	-0.088	None	None	-0.368	None	None	None	None	None	None	None	0.954	None	None	0.513	0.387	None	None	None	1.55E-05	0	0	0	0	None	0	None	1.55E-05	0	3.68E-05	0	None	N	None
8550	2	R/G	rs371161599	0.5082	gnomAD-4.0.0	2	None	0.423	0.4268	None	N	-0.088	None	None	-0.368	None	None	None	None	None	None	None	0.954	None	None	0.513	0.387	None	None	None	5.61101E-06	0	0	0	0	None	0	0	5.61101E-06	7.32605E-06	0	0	None	N	None
8550	2	R/M	None	0.5082	gnomAD-4.0.0	2	None	0.3867	0.3997	23.3	N	None	-0.31	0.038675	-0.109	0.4012	-0.1189	0.305917097717	None	1.0	0.476	0.542053899377	0.989	0.523558497429	-3.43	0.367	0.385	0.279	None	None	7.01471E-07	0	0	0	0	None	0	0	7.01471E-07	0	1.22178E-05	0	None	N	None
8550	2	R/S	rs2077385819	0.5082	gnomAD-4.0.0	2	None	0.5712	0.5771	22.4	N	None	-0.22	0.025183	-0.505	0.1394	-0.9417	0.15649385473	None	1.0	0.479	0.299086750705	0.911	0.499505519867	-3.19	0.367	0.371	0.546	None	None	8.40998E-06	0	5.15889E-05	0	0	None	0	0	8.40998E-06	9.0601E-06	0	0	None	N	None
8552	4	I/T	rs940884256	0.4675	gnomAD-2.1.1	4	None	0.2919	0.3186	24.0	N	-0.629	0.97	0.012591	-1.163	0.0629	-1.0736	0.108563578391	None	1.0	0.435	0.379020345274	0.003	0.618919789791	-2.78	0.213	0.135	0.036	None	None	5E-06	8.43E-05	0	0	0	None	0	None	5E-06	0	0	0	None	N	None
8552	4	I/T	rs940884256	0.4675	gnomAD-3.1.2	4	None	0.2919	0.3186	24.0	N	-0.629	0.97	0.012591	-1.163	0.0629	-1.0736	0.108563578391	None	1.0	0.435	0.379020345274	0.003	0.618919789791	-2.78	0.213	0.135	0.036	None	None	1.97E-05	7.24E-05	0	0	0	None	0	0	1.97E-05	0	0	0	None	N	None
8552	4	I/T	rs940884256	0.4675	gnomAD-4.0.0	4	None	0.2919	0.3186	24.0	N	-0.629	0.97	0.012591	-1.163	0.0629	-1.0736	0.108563578391	None	1.0	0.435	0.379020345274	0.003	0.618919789791	-2.78	0.213	0.135	0.036	None	None	5.05384E-06	9.42177E-05	0	0	0	None	0	0	5.05384E-06	0	0	1.63068E-05	None	N	None
8554	6	K/E	rs201945791	0.6609	gnomAD-2.1.1	7	None	0.7339	0.7114	None	N	0.537	None	None	0.574	None	None	None	None	None	None	None	0.992	None	None	0.259	0.649	None	None	None	1.15357E-04	0	0	0	0	None	0	None	1.15357E-04	4.38E-05	2.05991E-04	7.92644E-04	None	N	None
8554	6	K/E	rs201945791	0.6609	gnomAD-3.1.2	7	None	0.7339	0.7114	None	N	0.537	None	None	0.574	None	None	None	None	None	None	None	0.992	None	None	0.259	0.649	None	None	None	1.11732E-04	0	0	2.88184E-04	0	None	3.76648E-04	0	1.11732E-04	1.76424E-04	0	0	None	N	None
8554	6	K/E	rs201945791	0.6609	gnomAD-4.0.0	7	None	0.7339	0.7114	None	N	0.537	None	None	0.574	None	None	None	None	None	None	None	0.992	None	None	0.259	0.649	None	None	None	8.32718E-05	0	0	6.88089E-05	2.27967E-05	None	2.88785E-04	0	8.32718E-05	9.27845E-05	0	4.88647E-05	None	N	None
8554	6	K/N	rs568546539	0.6609	gnomAD-2.1.1	7	None	0.8144	0.8034	24.3	N	0.053	1.03	0.025198	-0.009	0.2221	-0.6879	0.499725207861	None	1.0	0.532	0.152612264143	0.999	0.666664600372	-2.71	0.238	0.733	0.138	None	None	4.92E-05	0	0	0	0	None	3.83054E-04	None	4.92E-05	0	0	0	None	N	None
8554	6	K/N	rs568546539	0.6609	gnomAD-3.1.2	7	None	0.8144	0.8034	24.3	N	0.053	1.03	0.025198	-0.009	0.2221	-0.6879	0.499725207861	None	1.0	0.532	0.152612264143	0.999	0.666664600372	-2.71	0.238	0.733	0.138	None	None	1.97E-05	0	0	0	0	None	0	0	1.97E-05	0	6.22148E-04	0	None	N	None
8554	6	K/N	rs568546539	0.6609	1000 genomes	7	None	0.8144	0.8034	24.3	N	0.053	1.03	0.025198	-0.009	0.2221	-0.6879	0.499725207861	None	1.0	0.532	0.152612264143	0.999	0.666664600372	-2.71	0.238	0.733	0.138	None	None	3.99361E-04	0	0	None	0	0	None	None	3.99361E-04	None	2E-03	None	None	N	None
8554	6	K/N	rs568546539	0.6609	gnomAD-4.0.0	7	None	0.8144	0.8034	24.3	N	0.053	1.03	0.025198	-0.009	0.2221	-0.6879	0.499725207861	None	1.0	0.532	0.152612264143	0.999	0.666664600372	-2.71	0.238	0.733	0.138	None	None	1.26109E-05	0	0	0	0	None	0	0	1.26109E-05	0	2.28556E-04	0	None	N	None
8555	7	L/Q	None	0.1822	gnomAD-4.0.0	8	None	0.8822	0.8732	28.1	D	None	0.74	0.055975	-1.64	0.4641	0.2818	0.473959320214	None	0.679903	0.549	0.721541066513	1.0	0.576174736023	-3.14	0.354	0.863	0.035	None	None	6.96823E-07	0	0	0	0	None	0	0	6.96823E-07	9.11472E-07	0	0	None	N	None
8556	8	E/D	None	0.6425	gnomAD-4.0.0	9	None	0.0833	0.0774	22.2	N	None	0.95	0.014953	-0.63	0.0712	-1.0129	0.0757698424566	None	1.0	0.343	0.16115917748	None	0.427482157946	-0.12	0.07	0.079	0.609	None	None	3.31776E-06	0	0	0	0	None	0	0	3.31776E-06	5.95813E-06	0	0	None	N	None
8557	9	P/T	None	0.7295	gnomAD-4.0.0	11	None	0.0976	0.0752	17.49	N	None	1.02	0.036306	-0.205	0.0855	-1.0002	0.0956197624706	None	1.0	0.377	0.126345400529	0.001	0.304463922977	-2.1	0.047	0.283	0.128	None	None	1.65379E-06	0	0	0	0	None	0	0	1.65379E-06	2.96969E-06	0	0	None	N	None
8559	11	R/K	rs745818225	0.2426	gnomAD-2.1.1	14	None	0.0881	0.082	22.1	N	0.088	-0.21	0.007643	-0.793	0.1557	-0.8943	0.0846194833038	None	1.0	0.485	0.382925413656	None	0.496939361095	-1.34	0.261	0.193	1.0	None	None	4.72E-06	0	0	0	0	None	0	None	4.72E-06	0	1.09E-05	0	None	I	None
8559	11	R/K	rs745818225	0.2426	gnomAD-4.0.0	14	None	0.0881	0.082	22.1	N	0.088	-0.21	0.007643	-0.793	0.1557	-0.8943	0.0846194833038	None	1.0	0.485	0.382925413656	None	0.496939361095	-1.34	0.261	0.193	1.0	None	None	2.08309E-06	0	0	0	0	None	0	0	2.08309E-06	2.72746E-06	0	0	None	I	None
8560	12	I/T	rs727504204	0.6596	gnomAD-4.0.0	16	None	0.0805	0.0886	20.1	N	None	-0.13	0.013483	-0.992	0.1523	-0.9278	0.105969166871	None	1.0	0.376	0.611125358375	None	0.559335529804	-2.36	0.184	0.085	0.652	None	None	1.38592E-06	0	0	0	0	None	0	0	1.38592E-06	9.07777E-07	1.19474E-05	0	None	I	None
8561	13	V/L	None	0.1836	gnomAD-4.0.0	17	None	0.1675	0.251	13.48	N	None	-0.53	0.026679	-0.679	0.282	-0.6634	0.0875116621447	None	1.0	0.73	0.529110813561	0.024	0.448378950357	-1.67	0.285	0.466	0.012	None	None	6.92609E-07	0	0	0	0	None	0	0	6.92609E-07	9.07438E-07	0	0	None	I	None
8561	13	V/M	None	0.1836	gnomAD-4.0.0	17	None	0.163	0.2009	14.55	N	None	-0.63	0.029655	-0.59	0.3549	-0.5798	0.113642866604	None	1.0	0.681	0.549249573952	0.172	0.476049542427	-1.76	0.337	0.423	0.004	None	None	6.23348E-06	3.01132E-05	0	0	0	None	0	0	6.23348E-06	7.2595E-06	0	0	None	I	None
8563	15	Q/E	None	0.4026	gnomAD-4.0.0	23	None	0.078	0.0734	22.4	N	None	1.28	0.012556	-0.324	0.0407	-1.0819	0.0906360963538	None	1.0	0.425	0.126345400529	0.002	0.449435651302	-1.16	0.038	0.147	0.819	None	None	2.76474E-06	0	0	0	0	None	0	0	2.76474E-06	3.6242E-06	0	0	None	I	None
8564	16	D/G	rs770623711	0.5978	gnomAD-2.1.1	24	None	0.0571	0.0645	16.45	N	-0.471	0.94	0.008892	-0.491	0.0196	-1.0383	0.110423370484	None	1.0	0.495	0.0297737177859	None	0.296409547329	-2.1	0.084	0.211	0.732	None	None	8.91E-06	0	0	0	0	None	0	None	8.91E-06	0	2.02E-05	0	None	I	None
8564	16	D/G	rs770623711	0.5978	gnomAD-4.0.0	24	None	0.0571	0.0645	16.45	N	-0.471	0.94	0.008892	-0.491	0.0196	-1.0383	0.110423370484	None	1.0	0.495	0.0297737177859	None	0.296409547329	-2.1	0.084	0.211	0.732	None	None	2.07109E-06	0	0	0	0	None	0	0	2.07109E-06	2.7158E-06	0	0	None	I	None
8567	19	T/A	rs777832511	0.1623	gnomAD-2.1.1	28	None	0.0726	0.0728	18.25	N	-0.846	1.23	0.00846	-0.924	0.0435	-1.0865	0.0825183256142	None	1.0	0.381	0.0806252709748	0.002	0.467278718948	-2.24	0.088	0.323	1.0	None	None	4.34E-06	7.09E-05	0	0	0	None	0	None	4.34E-06	0	0	0	None	N	None
8567	19	T/A	rs777832511	0.1623	gnomAD-3.1.2	28	None	0.0726	0.0728	18.25	N	-0.846	1.23	0.00846	-0.924	0.0435	-1.0865	0.0825183256142	None	1.0	0.381	0.0806252709748	0.002	0.467278718948	-2.24	0.088	0.323	1.0	None	None	1.97E-05	7.24E-05	0	0	0	None	0	0	1.97E-05	0	0	0	None	N	None
8567	19	T/A	rs777832511	0.1623	gnomAD-4.0.0	28	None	0.0726	0.0728	18.25	N	-0.846	1.23	0.00846	-0.924	0.0435	-1.0865	0.0825183256142	None	1.0	0.381	0.0806252709748	0.002	0.467278718948	-2.24	0.088	0.323	1.0	None	None	6.2339E-06	1.20334E-04	0	0	0	None	0	0	6.2339E-06	0	0	1.61005E-05	None	N	None
8567	19	T/K	rs867794054	0.1623	gnomAD-4.0.0	28	None	0.4683	0.4572	21.7	N	None	1.0	0.010295	-0.413	0.1005	-0.9058	0.141875730321	None	1.0	0.628	0.230578612272	0.864	0.545937955379	-2.98	0.192	0.751	0.033	None	None	1.61538E-06	0	0	0	0	None	0	2.41663E-04	1.61538E-06	0	0	0	None	N	None
8567	19	T/P	rs777832511	0.1623	gnomAD-2.1.1	28	None	0.4553	0.4322	22.0	N	-0.192	0.99	0.022167	-0.208	0.1565	-0.7963	0.301805727644	None	1.0	0.66	0.239305524855	0.906	0.479122549295	-3.21	0.237	0.809	0.046	None	None	4.34E-06	0	0	0	0	None	3.49E-05	None	4.34E-06	0	0	0	None	N	None
8567	19	T/P	rs777832511	0.1623	gnomAD-3.1.2	28	None	0.4553	0.4322	22.0	N	-0.192	0.99	0.022167	-0.208	0.1565	-0.7963	0.301805727644	None	1.0	0.66	0.239305524855	0.906	0.479122549295	-3.21	0.237	0.809	0.046	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	0	2.06868E-04	0	None	N	None
8567	19	T/P	rs777832511	0.1623	gnomAD-4.0.0	28	None	0.4553	0.4322	22.0	N	-0.192	0.99	0.022167	-0.208	0.1565	-0.7963	0.301805727644	None	1.0	0.66	0.239305524855	0.906	0.479122549295	-3.21	0.237	0.809	0.046	None	None	6.57263E-06	0	0	0	0	None	0	0	6.57263E-06	0	2.06868E-04	0	None	N	None
8568	20	R/M	None	0.2730	gnomAD-4.0.0	29	None	0.2063	0.2028	21.3	N	None	0.95	0.01699	-0.571	0.2044	-0.653	0.323446427214	None	1.0	0.627	0.254244900254	0.97	0.471251875162	-3.29	0.217	0.62	0.012	None	None	1.61428E-06	0	0	0	2.79861E-05	None	0	0	1.61428E-06	0	0	0	None	N	None
8568	20	R/S	None	0.2730	gnomAD-4.0.0	29	None	0.259	0.2583	18.76	N	None	1.0	0.024677	-1.262	0.0765	-1.0792	0.148230962481	None	1.0	0.581	0.117506650769	0.642	0.445262253284	-3.19	0.158	0.547	0.029	None	None	6.88015E-07	0	0	0	0	None	0	0	6.88015E-07	0	0	1.66478E-05	None	N	None
8570	22	E/K	rs552462622	0.3221	gnomAD-2.1.1	31	None	0.2803	0.274	None	N	-0.253	None	None	-0.694	None	None	None	None	None	None	None	0.883	None	None	0.404	0.487	None	None	None	4.12E-05	0	0	0	0	None	0	None	4.12E-05	4.08E-05	8.26E-05	0	None	N	None
8570	22	E/K	rs552462622	0.3221	gnomAD-3.1.2	31	None	0.2803	0.274	None	N	-0.253	None	None	-0.694	None	None	None	None	None	None	None	0.883	None	None	0.404	0.487	None	None	None	7.23E-05	9.66E-05	0	0	0	None	0	0	7.23E-05	1.02938E-04	0	0	None	N	None
8570	22	E/K	rs552462622	0.3221	1000 genomes	31	None	0.2803	0.274	None	N	-0.253	None	None	-0.694	None	None	None	None	None	None	None	0.883	None	None	0.404	0.487	None	None	None	1.99681E-04	8E-04	0	None	0	0	None	None	1.99681E-04	None	0	None	None	N	None
8570	22	E/K	rs552462622	0.3221	gnomAD-4.0.0	31	None	0.2803	0.274	None	N	-0.253	None	None	-0.694	None	None	None	None	None	None	None	0.883	None	None	0.404	0.487	None	None	None	1.44985E-04	5.33732E-05	0	0	0	None	4.71313E-05	0	1.44985E-04	1.9045E-04	0	3.21399E-05	None	N	None
8573	25	I/L	rs142609645	0.1131	gnomAD-2.1.1	35	None	0.2224	0.2009	None	N	-0.557	None	None	-0.588	None	None	None	None	None	None	None	0.009	None	None	0.236	0.453	None	None	None	1.1E-05	1.27378E-04	0	0	0	None	0	None	1.1E-05	0	0	0	None	N	None
8573	25	I/L	rs142609645	0.1131	gnomAD-3.1.2	35	None	0.2224	0.2009	None	N	-0.557	None	None	-0.588	None	None	None	None	None	None	None	0.009	None	None	0.236	0.453	None	None	None	7.23E-05	2.65393E-04	0	0	0	None	0	0	7.23E-05	0	0	0	None	N	None
8573	25	I/L	rs142609645	0.1131	1000 genomes	35	None	0.2224	0.2009	None	N	-0.557	None	None	-0.588	None	None	None	None	None	None	None	0.009	None	None	0.236	0.453	None	None	None	1.99681E-04	8E-04	0	None	0	0	None	None	1.99681E-04	None	0	None	None	N	None
8573	25	I/L	rs142609645	0.1131	gnomAD-4.0.0	35	None	0.2224	0.2009	None	N	-0.557	None	None	-0.588	None	None	None	None	None	None	None	0.009	None	None	0.236	0.453	None	None	None	8.07615E-06	1.73356E-04	0	0	0	None	0	0	8.07615E-06	0	0	0	None	N	None
8574	26	G/D	None	0.2452	gnomAD-4.0.0	38	None	0.5405	0.5334	22.3	N	None	-0.18	0.019036	-0.362	0.1485	-0.7883	0.177791290369	None	1.0	0.47	0.340753184043	0.656	0.626826703548	-3.35	0.153	0.391	0.621	None	None	6.85839E-07	0	0	0	0	None	0	0	6.85839E-07	9.00922E-07	0	0	None	N	None
8574	26	G/R	None	0.2452	gnomAD-4.0.0	38	None	0.442	0.4221	22.8	N	None	-0.17	0.029133	-0.691	0.1843	-0.7384	0.338333237908	None	1.0	0.452	0.589131389434	0.979	0.608427464962	-3.76	0.256	0.442	0.437	None	None	6.85979E-07	0	0	3.83966E-05	0	None	0	0	6.85979E-07	0	0	0	None	N	None
8574	26	G/S	rs752013701	0.2452	gnomAD-2.1.1	38	None	0.0824	0.0812	None	N	-0.454	None	None	-0.991	None	None	None	None	None	None	None	0.028	None	None	0.107	0.11	None	None	None	1.83E-05	8.47E-05	0	0	0	None	0	None	1.83E-05	0	2.42E-05	0	None	N	None
8574	26	G/S	rs752013701	0.2452	gnomAD-3.1.2	38	None	0.0824	0.0812	None	N	-0.454	None	None	-0.991	None	None	None	None	None	None	None	0.028	None	None	0.107	0.11	None	None	None	3.29E-05	9.67E-05	0	0	0	None	0	0	3.29E-05	1.47E-05	0	0	None	N	None
8574	26	G/S	rs752013701	0.2452	gnomAD-4.0.0	38	None	0.0824	0.0812	None	N	-0.454	None	None	-0.991	None	None	None	None	None	None	None	0.028	None	None	0.107	0.11	None	None	None	5.59085E-06	6.68396E-05	0	0	0	None	0	0	5.59085E-06	3.39619E-06	0	0	None	N	None
8575	27	G/E	None	0.4817	gnomAD-4.0.0	40	None	0.9894	0.991	25.0	D	None	-1.14	0.130628	-0.807	0.787	0.8711	0.526218639335	None	0.999523	0.859	0.713204199129	1.0	0.671988070011	-4.16	0.864	0.823	0.014	None	None	1.59856E-06	0	0	0	0	None	1.88829E-05	0	1.59856E-06	0	0	0	None	I	None
8575	27	G/R	rs397517517	0.4817	gnomAD-2.1.1	40	None	0.9866	0.9876	24.1	D	-0.425	-1.32	0.123608	-0.498	0.835	0.9811	0.506463245118	None	0.999545	0.871	0.816574466228	1.0	0.690957307816	-4.25	0.819	0.809	0.007	None	None	8.25E-06	0	2.96E-05	0	0	None	0	None	8.25E-06	0	9.16E-06	0	None	I	None
8575	27	G/R	rs397517517	0.4817	gnomAD-3.1.2	40	None	0.9866	0.9876	24.1	D	-0.425	-1.32	0.123608	-0.498	0.835	0.9811	0.506463245118	None	0.999545	0.871	0.816574466228	1.0	0.690957307816	-4.25	0.819	0.809	0.007	None	None	1.97E-05	0	6.56E-05	0	0	None	0	0	1.97E-05	2.94E-05	0	0	None	I	None
8575	27	G/R	rs397517517	0.4817	gnomAD-4.0.0	40	None	0.9866	0.9876	24.1	D	-0.425	-1.32	0.123608	-0.498	0.835	0.9811	0.506463245118	None	0.999545	0.871	0.816574466228	1.0	0.690957307816	-4.25	0.819	0.809	0.007	None	None	9.93517E-06	0	3.36146E-05	0	0	None	0	0	9.93517E-06	1.10343E-05	0	1.60452E-05	None	I	None
8576	28	S/F	rs376095355	0.7458	gnomAD-2.1.1	41	None	0.2105	0.2423	None	N	-0.74	None	None	-0.789	None	None	None	None	None	None	None	1.0	None	None	0.45	0.592	None	None	None	8.2E-06	0	0	0	0	None	0	None	8.2E-06	0	9.09E-06	1.68577E-04	None	I	None
8576	28	S/F	rs376095355	0.7458	gnomAD-4.0.0	41	None	0.2105	0.2423	None	N	-0.74	None	None	-0.789	None	None	None	None	None	None	None	1.0	None	None	0.45	0.592	None	None	None	1.16503E-05	0	0	0	0	None	0	0	1.16503E-05	1.1706E-05	0	6.63768E-05	None	I	None
8576	28	S/P	rs1176708240	0.7458	gnomAD-2.1.1	41	None	0.8661	0.8911	24.4	D	-0.081	-0.32	0.053473	-0.045	0.5263	0.2613	0.446521708451	None	0.733498	0.562	0.52628473709	0.998	0.502356112003	-2.91	0.492	0.431	0.032	None	None	4.11E-06	0	0	0	0	None	3.34E-05	None	4.11E-06	0	0	0	None	I	None
8576	28	S/P	rs1176708240	0.7458	gnomAD-3.1.2	41	None	0.8661	0.8911	24.4	D	-0.081	-0.32	0.053473	-0.045	0.5263	0.2613	0.446521708451	None	0.733498	0.562	0.52628473709	0.998	0.502356112003	-2.91	0.492	0.431	0.032	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	0	2.07814E-04	0	None	I	None
8576	28	S/P	rs1176708240	0.7458	gnomAD-4.0.0	41	None	0.8661	0.8911	24.4	D	-0.081	-0.32	0.053473	-0.045	0.5263	0.2613	0.446521708451	None	0.733498	0.562	0.52628473709	0.998	0.502356112003	-2.91	0.492	0.431	0.032	None	None	6.42695E-06	0	0	0	0	None	0	2.24115E-04	6.42695E-06	0	5.39345E-05	0	None	I	None
8577	29	P/T	None	0.5536	gnomAD-4.0.0	42	None	0.3484	0.3348	23.0	D	None	-0.83	0.050823	-0.41	0.5659	0.1257	0.100522647085	None	1.0	0.846	0.418095516054	0.03	0.491968095303	-4.2	0.602	0.261	0.139	None	None	1.59731E-06	0	0	0	0	None	0	0	1.59731E-06	2.86814E-06	0	0	None	I	None
8579	31	I/F	None	0.1699	gnomAD-4.0.0	44	None	0.3921	0.4039	24.1	D	None	-0.26	0.042758	-1.555	0.2735	-0.6156	0.135862692089	None	0.667002	0.577	0.513280433867	0.013	0.576436400414	-1.74	0.307	0.349	0.057	None	None	6.84841E-07	2.98989E-05	0	0	0	None	0	0	6.84841E-07	0	0	0	None	I	None
8579	31	I/V	None	0.1699	gnomAD-4.0.0	44	None	0.1879	0.1901	23.5	D	None	-0.22	0.02765	-1.515	0.2783	-0.5932	0.0769748553419	None	1.0	0.437	0.556183318313	0.035	0.497694432735	-0.54	0.158	0.387	1.0	None	None	1.36968E-06	0	0	0	0	None	0	0	1.36968E-06	8.99977E-07	1.1629E-05	0	None	I	None
8580	32	K/R	None	0.6621	gnomAD-4.0.0	45	None	0.0754	0.0767	23.8	N	None	-0.29	0.023867	-0.472	0.1887	-0.8153	0.0693150109517	None	1.0	0.454	0.267299060538	None	0.483807146549	-1.59	0.103	0.134	0.277	None	None	1.59385E-06	0	0	0	0	None	0	0	1.59385E-06	0	1.43674E-05	0	None	I	None
8581	33	V/F	None	0.2361	gnomAD-4.0.0	46	None	0.543	0.5226	22.8	D	None	-1.02	0.060438	-1.218	0.3999	-0.3393	0.117290986297	None	1.0	0.708	0.689457545739	0.007	0.543990492821	-3.21	0.578	0.602	0.09	None	None	6.84702E-07	0	0	0	0	None	0	0	6.84702E-07	8.99863E-07	0	0	None	N	None
8581	33	V/I	rs1014791707	0.2361	gnomAD-4.0.0	46	None	0.0978	0.09	22.4	N	None	-0.64	0.031784	-0.637	0.2138	-0.7802	0.0687624967998	None	1.0	0.669	0.518092603711	None	0.430460065603	-0.54	0.178	0.285	0.147	None	None	3.42351E-06	0	0	0	2.52309E-05	None	0	0	3.42351E-06	2.69959E-06	1.16198E-05	0	None	N	None
8581	33	V/L	rs1014791707	0.2361	gnomAD-2.1.1	46	None	0.5144	0.4599	22.6	D	-0.552	-0.95	0.049091	-0.637	0.3723	-0.3818	0.0836723866774	None	1.0	0.685	0.48286525802	0.006	0.559740900993	-1.77	0.505	0.519	0.022	None	None	4.06E-06	0	0	0	5.63E-05	None	0	None	4.06E-06	0	0	0	None	N	None
8581	33	V/L	rs1014791707	0.2361	gnomAD-4.0.0	46	None	0.5144	0.4599	22.6	D	-0.552	-0.95	0.049091	-0.637	0.3723	-0.3818	0.0836723866774	None	1.0	0.685	0.48286525802	0.006	0.559740900993	-1.77	0.505	0.519	0.022	None	None	1.36941E-06	0	0	0	5.04643E-05	None	0	0	1.36941E-06	0	0	0	None	N	None
8582	34	L/S	None	0.3679	gnomAD-4.0.0	47	None	0.1048	0.0964	21.1	N	None	0.04	0.021173	-2.062	0.1289	-0.9215	0.126162368055	None	0.999998	0.428	0.585261766934	0.123	0.449342131615	-2.36	0.22	0.469	0.564	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
8582	34	L/V	rs1420202972	0.3679	gnomAD-2.1.1	47	None	0.06	0.0608	18.94	N	-1.593	-0.19	0.009785	-1.459	0.0881	-1.0533	0.0842442114282	None	0.999214	0.436	0.245101548738	None	0.406054198742	-1.31	0.094	0.219	0.34	None	None	7.18E-06	0	0	0	0	None	0	None	7.18E-06	0	1.57E-05	0	None	N	None
8582	34	L/V	rs1420202972	0.3679	gnomAD-3.1.2	47	None	0.06	0.0608	18.94	N	-1.593	-0.19	0.009785	-1.459	0.0881	-1.0533	0.0842442114282	None	0.999214	0.436	0.245101548738	None	0.406054198742	-1.31	0.094	0.219	0.34	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	1.47E-05	0	0	None	N	None
8582	34	L/V	rs1420202972	0.3679	gnomAD-4.0.0	47	None	0.06	0.0608	18.94	N	-1.593	-0.19	0.009785	-1.459	0.0881	-1.0533	0.0842442114282	None	0.999214	0.436	0.245101548738	None	0.406054198742	-1.31	0.094	0.219	0.34	None	None	2.56512E-06	0	0	0	0	None	0	0	2.56512E-06	4.79067E-06	0	0	None	N	None
8583	35	W/R	None	0.1471	gnomAD-4.0.0	48	None	0.9987	0.9985	25.9	D	None	-3.97	0.450424	-2.068	0.9694	1.072	0.61613149071	None	0.987931	0.888	0.942336615409	1.0	0.813623607159	-8.91	0.935	0.889	0.006	None	None	2.05362E-06	0	0	0	0	None	0	0	2.05362E-06	2.69924E-06	0	0	None	N	None
8584	36	Y/C	rs1440957407	0.2160	gnomAD-2.1.1	49	None	0.3932	0.3667	27.0	N	None	0.82	0.027422	-1.536	0.3787	-0.0344	0.456623757881	None	0.535408	0.592	0.475741759771	0.999	0.704566836357	-4.86	0.315	0.674	0.06	None	None	3.18E-05	0	0	0	0	None	0	None	3.18E-05	0	6.48E-05	0	None	N	None
8584	36	Y/C	rs1440957407	0.2160	gnomAD-3.1.2	49	None	0.3932	0.3667	27.0	N	None	0.82	0.027422	-1.536	0.3787	-0.0344	0.456623757881	None	0.535408	0.592	0.475741759771	0.999	0.704566836357	-4.86	0.315	0.674	0.06	None	None	1.31E-05	0	0	0	0	None	0	0	1.31E-05	2.94E-05	0	0	None	N	None
8584	36	Y/C	rs1440957407	0.2160	gnomAD-4.0.0	49	None	0.3932	0.3667	27.0	N	None	0.82	0.027422	-1.536	0.3787	-0.0344	0.456623757881	None	0.535408	0.592	0.475741759771	0.999	0.704566836357	-4.86	0.315	0.674	0.06	None	None	1.3146E-05	0	0	0	0	None	0	0	1.3146E-05	2.94066E-05	0	0	None	N	None
8584	36	Y/H	None	0.2160	gnomAD-4.0.0	49	None	0.2896	0.2662	26.3	N	None	0.84	0.023476	-1.591	0.3139	-0.2829	0.447988326358	None	0.955821	0.646	0.350964488264	0.989	0.703381717205	-2.69	0.361	0.667	0.247	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	0	6.07533E-05	0	None	N	None
8586	38	D/N	rs1199035064	0.4219	gnomAD-2.1.1	51	None	0.0704	0.0771	23.0	N	-0.546	1.02	0.006664	-0.426	0.0521	-1.0736	0.08135469169	None	0.999491	0.63	0.12205267543	None	0.341029495001	-2.21	0.086	0.091	0.353	None	None	4.03E-06	6.48E-05	0	0	0	None	0	None	4.03E-06	0	0	0	None	N	None
8586	38	D/N	rs1199035064	0.4219	gnomAD-4.0.0	51	None	0.0704	0.0771	23.0	N	-0.546	1.02	0.006664	-0.426	0.0521	-1.0736	0.08135469169	None	0.999491	0.63	0.12205267543	None	0.341029495001	-2.21	0.086	0.091	0.353	None	None	3.42209E-06	1.19581E-04	0	0	0	None	0	0	3.42209E-06	0	0	1.65711E-05	None	N	None
8586	38	D/V	rs1484446680	0.4219	gnomAD-2.1.1	51	None	0.394	0.4509	23.3	N	-0.067	0.68	0.038087	-0.12	0.1719	-0.8216	0.133285523409	None	0.75222	0.642	0.322230723748	0.013	0.312399148941	-4.84	0.215	0.479	0.135	None	None	4.03E-06	0	0	0	0	None	3.28E-05	None	4.03E-06	0	0	0	None	N	None
8586	38	D/V	rs1484446680	0.4219	gnomAD-4.0.0	51	None	0.394	0.4509	23.3	N	-0.067	0.68	0.038087	-0.12	0.1719	-0.8216	0.133285523409	None	0.75222	0.642	0.322230723748	0.013	0.312399148941	-4.84	0.215	0.479	0.135	None	None	1.5924E-06	0	0	0	0	None	0	0	1.5924E-06	0	1.43386E-05	0	None	N	None
8587	39	E/D	rs2077371991	0.7746	gnomAD-4.0.0	52	None	0.1084	0.102	22.6	N	None	1.08	0.010454	-0.269	0.0411	-1.0549	0.0757698424566	None	1.0	0.457	0.0920862733494	None	0.390031635761	-1.26	0.068	0.145	0.804	None	None	1.59227E-06	0	0	0	0	None	0	0	1.59227E-06	2.86004E-06	0	0	None	N	None
8587	39	E/K	rs760340908	0.7746	gnomAD-2.1.1	52	None	0.1584	0.1349	22.8	N	-0.022	1.01	0.020155	0.333	0.0955	-0.9544	0.116427427619	None	0.980451	0.601	0.20549828249	0.659	0.459544628859	-2.45	0.224	0.37	0.521	None	None	8.07E-06	0	0	0	5.59E-05	None	0	None	8.07E-06	0	8.91E-06	0	None	N	None
8587	39	E/K	rs760340908	0.7746	gnomAD-4.0.0	52	None	0.1584	0.1349	22.8	N	-0.022	1.01	0.020155	0.333	0.0955	-0.9544	0.116427427619	None	0.980451	0.601	0.20549828249	0.659	0.459544628859	-2.45	0.224	0.37	0.521	None	None	1.09508E-05	2.98936E-05	0	0	2.52181E-05	None	0	0	1.09508E-05	1.07962E-05	0	3.31422E-05	None	N	None
8587	39	E/Q	rs760340908	0.7746	gnomAD-2.1.1	52	None	0.1848	0.1696	22.5	N	-0.464	0.95	0.015424	0.01	0.1308	-0.9179	0.141824913144	None	0.921585	0.51	0.18995819373	0.384	0.381830841303	-1.86	0.173	0.39	0.352	None	None	4.03E-06	6.48E-05	0	0	0	None	0	None	4.03E-06	0	0	0	None	N	None
8587	39	E/Q	rs760340908	0.7746	gnomAD-3.1.2	52	None	0.1848	0.1696	22.5	N	-0.464	0.95	0.015424	0.01	0.1308	-0.9179	0.141824913144	None	0.921585	0.51	0.18995819373	0.384	0.381830841303	-1.86	0.173	0.39	0.352	None	None	6.58E-06	2.41E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
8587	39	E/Q	rs760340908	0.7746	gnomAD-4.0.0	52	None	0.1848	0.1696	22.5	N	-0.464	0.95	0.015424	0.01	0.1308	-0.9179	0.141824913144	None	0.921585	0.51	0.18995819373	0.384	0.381830841303	-1.86	0.173	0.39	0.352	None	None	6.57609E-06	2.41301E-05	0	0	0	None	0	0	6.57609E-06	0	0	0	None	N	None
8593	45	S/R	rs560562125	0.2341	gnomAD-2.1.1	73	None	0.7274	0.7241	24.0	N	-0.086	0.78	0.045025	-0.307	0.1989	-0.7452	0.277109235105	None	1.0	0.612	0.260735089382	0.92	0.442696988583	-3.06	0.257	0.329	0.022	None	None	4.02E-06	0	0	0	0	None	3.27E-05	None	4.02E-06	0	0	0	None	N	None
8593	45	S/R	rs560562125	0.2341	gnomAD-3.1.2	73	None	0.7274	0.7241	24.0	N	-0.086	0.78	0.045025	-0.307	0.1989	-0.7452	0.277109235105	None	1.0	0.612	0.260735089382	0.92	0.442696988583	-3.06	0.257	0.329	0.022	None	None	6.58E-06	0	0	0	0	None	0	0	6.58E-06	0	2.08247E-04	0	None	N	None
8593	45	S/R	rs560562125	0.2341	1000 genomes	73	None	0.7274	0.7241	24.0	N	-0.086	0.78	0.045025	-0.307	0.1989	-0.7452	0.277109235105	None	1.0	0.612	0.260735089382	0.92	0.442696988583	-3.06	0.257	0.329	0.022	None	None	1.99681E-04	0	0	None	0	0	None	None	1.99681E-04	None	1E-03	None	None	N	None
8593	45	S/R	rs560562125	0.2341	gnomAD-4.0.0	73	None	0.7274	0.7241	24.0	N	-0.086	0.78	0.045025	-0.307	0.1989	-0.7452	0.277109235105	None	1.0	0.612	0.260735089382	0.92	0.442696988583	-3.06	0.257	0.329	0.022	None	None	6.57255E-06	0	0	0	0	None	0	0	6.57255E-06	0	2.0842E-04	0	None	N	None
8594	46	S/G	None	0.7302	gnomAD-4.0.0	111	None	0.0639	0.0657	22.8	N	None	1.07	0.009074	-0.39	0.065	-1.0693	0.0766810984944	None	1.0	0.44	0.0551355673512	None	0.316866159439	-2.01	0.156	0.137	0.406	None	None	2.40064E-06	0	0	0	0	None	0	0	2.40064E-06	2.625E-06	0	0	None	N	None
8594	46	S/N	rs759108676	0.7302	gnomAD-2.1.1	111	None	0.0682	0.0694	22.2	N	-0.025	0.96	0.012021	-0.166	0.0733	-1.054	0.0777257753559	None	0.999981	0.419	0.0297737177859	None	0.359258115292	-1.44	0.051	0.16	0.46	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.88E-06	0	None	N	None
8594	46	S/N	rs759108676	0.7302	gnomAD-4.0.0	111	None	0.0682	0.0694	22.2	N	-0.025	0.96	0.012021	-0.166	0.0733	-1.054	0.0777257753559	None	0.999981	0.419	0.0297737177859	None	0.359258115292	-1.44	0.051	0.16	0.46	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
8594	46	S/R	None	0.7302	gnomAD-4.0.0	111	None	0.1584	0.1589	21.8	N	None	0.95	0.01444	-0.251	0.0688	-1.0562	0.102699699016	None	0.999995	0.523	0.0884992946249	0.138	0.363965213299	-2.46	0.149	0.309	0.443	None	None	6.84299E-07	0	0	0	0	None	0	0	6.84299E-07	8.99565E-07	0	0	None	N	None
8595	47	K/N	None	0.1958	gnomAD-4.0.0	115	None	0.496	0.4476	22.9	N	None	0.93	0.017393	-0.482	0.0854	-1.0566	0.101771959714	None	1.0	0.599	0.0806252709748	0.019	0.432372868061	-2.83	0.06	0.073	0.166	None	None	1.59172E-06	0	0	0	0	None	0	0	1.59172E-06	2.85914E-06	0	0	None	N	None
8595	47	K/Q	None	0.1958	gnomAD-4.0.0	115	None	0.2158	0.1889	22.4	N	None	0.88	0.020185	-0.518	0.1339	-0.9411	0.090178241661	None	1.0	0.596	0.104622674875	0.006	0.3920981884	-2.31	0.184	0.189	0.064	None	None	1.36859E-06	0	4.47507E-05	0	0	None	0	0	1.36859E-06	0	0	0	None	N	None
8595	47	K/R	rs774140425	0.1958	gnomAD-2.1.1	115	None	0.0849	0.0814	23.5	N	-0.301	1.25	0.018268	-0.6	0.0792	-1.0419	0.094160276228	None	1.0	0.512	0.119812018005	0.241	0.380584597588	-1.18	0.09	0.285	0.201	None	None	2.01E-05	0	1.16117E-04	0	0	None	0	None	2.01E-05	0	8.88E-06	0	None	N	None
8595	47	K/R	rs774140425	0.1958	gnomAD-3.1.2	115	None	0.0849	0.0814	23.5	N	-0.301	1.25	0.018268	-0.6	0.0792	-1.0419	0.094160276228	None	1.0	0.512	0.119812018005	0.241	0.380584597588	-1.18	0.09	0.285	0.201	None	None	6.57E-06	0	6.56E-05	0	0	None	0	0	6.57E-06	0	0	0	None	N	None
8595	47	K/R	rs774140425	0.1958	gnomAD-4.0.0	115	None	0.0849	0.0814	23.5	N	-0.301	1.25	0.018268	-0.6	0.0792	-1.0419	0.094160276228	None	1.0	0.512	0.119812018005	0.241	0.380584597588	-1.18	0.09	0.285	0.201	None	None	1.66584E-05	0	1.01764E-04	0	0	None	0	0	1.66584E-05	7.18119E-06	0	1.13824E-04	None	N	None
8598	50	M/I	rs770947302	0.2153	gnomAD-2.1.1	123	None	0.3904	0.4079	22.6	N	-0.061	-0.1	0.042276	-1.171	0.1767	-0.8802	0.0925954833539	None	1.0	0.51	0.433157607263	None	0.481393069029	-1.89	0.132	0.096	1.0	None	None	1.21E-05	0	0	0	1.11483E-04	None	3.27E-05	None	1.21E-05	0	0	0	None	I	None
8598	50	M/I	rs770947302	0.2153	gnomAD-4.0.0	123	None	0.3904	0.4079	22.6	N	-0.061	-0.1	0.042276	-1.171	0.1767	-0.8802	0.0925954833539	None	1.0	0.51	0.433157607263	None	0.481393069029	-1.89	0.132	0.096	1.0	None	None	3.18338E-06	0	0	0	2.77346E-05	None	0	0	3.18338E-06	0	1.43308E-05	0	None	I	None
8598	50	M/T	None	0.2153	gnomAD-4.0.0	123	None	0.4225	0.4217	23.2	D	None	-0.28	0.091716	-1.572	0.2719	-0.623	0.0966260119837	None	1.0	0.581	0.777005541942	None	0.574620723724	-3.26	0.312	0.165	0.05	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	I	None
8598	50	M/V	rs1180662147	0.2153	gnomAD-3.1.2	123	None	0.1607	0.1663	21.9	N	None	0.01	0.056992	-1.519	0.1736	-0.8131	0.085014186535	None	1.0	0.486	0.423836183345	0.003	0.425749450922	-1.84	0.177	0.205	0.193	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	I	None
8598	50	M/V	rs1180662147	0.2153	gnomAD-4.0.0	123	None	0.1607	0.1663	21.9	N	None	0.01	0.056992	-1.519	0.1736	-0.8131	0.085014186535	None	1.0	0.486	0.423836183345	0.003	0.425749450922	-1.84	0.177	0.205	0.193	None	None	6.57393E-06	0	0	0	0	None	0	0	6.57393E-06	1.47016E-05	0	0	None	I	None
8600	52	F/L	None	0.3319	gnomAD-4.0.0	127	None	0.9512	0.925	21.0	N	None	-0.23	0.020497	-0.921	0.2661	-0.6332	0.276218049326	None	0.999999	0.558	0.335910606209	0.97	0.692070364952	-2.74	0.357	0.635	0.641	None	None	1.59164E-06	0	0	0	0	None	0	0	1.59164E-06	0	1.43295E-05	0	None	N	None
8600	52	F/Y	None	0.3319	gnomAD-4.0.0	127	None	0.3721	0.3204	25.4	N	None	-0.2	0.017049	-0.241	0.2912	-0.4474	0.352166808134	None	1.0	0.487	0.530655398971	0.989	0.676771879196	-1.39	0.326	0.651	1.0	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	N	None
8601	53	V/F	rs184812963	0.6599	gnomAD-2.1.1	130	None	0.128	0.1211	None	N	-0.396	None	None	-0.5	None	None	None	None	None	None	None	0.069	None	None	0.113	0.372	None	None	None	5E-05	0	0	0	7.1817E-04	None	0	None	5E-05	0	0	0	None	I	None
8601	53	V/F	rs184812963	0.6599	gnomAD-3.1.2	130	None	0.128	0.1211	None	N	-0.396	None	None	-0.5	None	None	None	None	None	None	None	0.069	None	None	0.113	0.372	None	None	None	1.97E-05	0	6.55E-05	0	3.8625E-04	None	0	0	1.97E-05	0	0	0	None	I	None
8601	53	V/F	rs184812963	0.6599	1000 genomes	130	None	0.128	0.1211	None	N	-0.396	None	None	-0.5	None	None	None	None	None	None	None	0.069	None	None	0.113	0.372	None	None	None	1.99681E-04	0	1.4E-03	None	0	0	None	None	1.99681E-04	None	0	None	None	I	None
8601	53	V/F	rs184812963	0.6599	gnomAD-4.0.0	130	None	0.128	0.1211	None	N	-0.396	None	None	-0.5	None	None	None	None	None	None	None	0.069	None	None	0.113	0.372	None	None	None	1.42535E-05	0	1.66689E-05	0	4.68227E-04	None	0	0	1.42535E-05	0	0	1.60087E-05	None	I	None
8601	53	V/I	rs184812963	0.6599	gnomAD-2.1.1	130	None	0.0675	0.0676	None	N	0.196	None	None	-0.211	None	None	None	None	None	None	None	None	None	None	0.116	0.181	None	None	None	4.02E-06	0	0	0	0	None	3.27E-05	None	4.02E-06	0	0	0	None	I	None
8601	53	V/I	rs184812963	0.6599	gnomAD-4.0.0	130	None	0.0675	0.0676	None	N	0.196	None	None	-0.211	None	None	None	None	None	None	None	None	None	None	0.116	0.181	None	None	None	5.47425E-06	0	0	3.82702E-05	5.03981E-05	None	1.87322E-05	0	5.47425E-06	1.79911E-06	1.15942E-05	1.65689E-05	None	I	None
8602	54	D/E	None	0.9060	gnomAD-4.0.0	131	None	0.2649	0.1749	20.7	N	None	0.99	0.009394	-0.422	0.0805	-1.0518	0.0815315654178	None	1.0	0.618	0.0611884634855	0.006	0.574462413788	-2.11	0.06	0.255	0.92	None	None	6.84271E-07	0	0	0	0	None	0	0	6.84271E-07	0	0	1.65673E-05	None	I	None
8603	55	S/L	rs781354478	0.3473	gnomAD-2.1.1	134	None	0.0996	0.1008	22.3	D	0.144	-0.31	0.06377	0.144	0.3047	-0.3584	0.214485801708	None	1.0	0.512	0.684870435166	0.934	0.514146447182	-3.3	0.372	0.581	0.022	None	None	1.21E-05	0	0	0	0	None	0	None	1.21E-05	0	2.66E-05	0	None	N	None
8603	55	S/L	rs781354478	0.3473	gnomAD-3.1.2	134	None	0.0996	0.1008	22.3	D	0.144	-0.31	0.06377	0.144	0.3047	-0.3584	0.214485801708	None	1.0	0.512	0.684870435166	0.934	0.514146447182	-3.3	0.372	0.581	0.022	None	None	1.32E-05	2.42E-05	0	0	0	None	0	0	1.32E-05	0	2.07814E-04	0	None	N	None
8603	55	S/L	rs781354478	0.3473	gnomAD-4.0.0	134	None	0.0996	0.1008	22.3	D	0.144	-0.31	0.06377	0.144	0.3047	-0.3584	0.214485801708	None	1.0	0.512	0.684870435166	0.934	0.514146447182	-3.3	0.372	0.581	0.022	None	None	6.81796E-06	1.33622E-05	0	0	2.22955E-05	None	0	0	6.81796E-06	4.23852E-06	4.3928E-05	0	None	N	None
8603	55	S/P	rs748398405	0.3473	gnomAD-2.1.1	134	None	0.6667	0.6044	22.4	N	-0.758	-0.32	0.049403	-0.022	0.3713	-0.2285	0.283932611558	None	1.0	0.595	0.352693368174	0.826	0.505831718445	-2.43	0.378	0.611	0.072	None	None	4.02E-06	6.46E-05	0	0	0	None	0	None	4.02E-06	0	0	0	None	N	None
8603	55	S/P	rs748398405	0.3473	gnomAD-3.1.2	134	None	0.6667	0.6044	22.4	N	-0.758	-0.32	0.049403	-0.022	0.3713	-0.2285	0.283932611558	None	1.0	0.595	0.352693368174	0.826	0.505831718445	-2.43	0.378	0.611	0.072	None	None	6.57E-06	2.41E-05	0	0	0	None	0	0	6.57E-06	0	0	0	None	N	None
8603	55	S/P	rs748398405	0.3473	gnomAD-4.0.0	134	None	0.6667	0.6044	22.4	N	-0.758	-0.32	0.049403	-0.022	0.3713	-0.2285	0.283932611558	None	1.0	0.595	0.352693368174	0.826	0.505831718445	-2.43	0.378	0.611	0.072	None	None	6.57324E-06	2.4122E-05	0	0	0	None	0	0	6.57324E-06	0	0	0	None	N	None
8603	55	S/W	None	0.3473	gnomAD-4.0.0	134	None	0.3874	0.3901	22.8	D	None	-0.34	0.066225	-0.771	0.5376	0.2856	0.505556540671	None	0.983294	0.576	0.797057192974	0.998	0.542234063148	-4.12	0.487	0.706	0.01	None	None	6.84275E-07	0	0	0	0	None	0	0	6.84275E-07	8.99549E-07	0	0	None	N	None
8604	56	V/A	None	0.2274	gnomAD-4.0.0	135	None	0.1891	0.1841	23.4	N	None	-0.19	0.071035	-1.607	0.2452	-0.4447	0.191392387725	None	0.598931	0.41	0.644857554221	0.954	0.514060199261	-2.56	0.323	0.498	0.623	None	None	1.59158E-06	0	0	0	0	None	0	0	1.59158E-06	0	1.43283E-05	0	None	N	None
8604	56	V/M	rs1160730554	0.2274	gnomAD-2.1.1	135	None	0.0834	0.0865	20.8	N	-0.365	-0.26	0.057715	-0.569	0.3456	-0.2118	0.238504508578	None	0.782863	0.474	0.556850889111	0.99	0.523394346237	-1.92	0.323	0.75	0.117	None	None	4.02E-06	6.46E-05	0	0	0	None	0	None	4.02E-06	0	0	0	None	N	None
8604	56	V/M	rs1160730554	0.2274	gnomAD-4.0.0	135	None	0.0834	0.0865	20.8	N	-0.365	-0.26	0.057715	-0.569	0.3456	-0.2118	0.238504508578	None	0.782863	0.474	0.556850889111	0.99	0.523394346237	-1.92	0.323	0.75	0.117	None	None	1.59157E-06	5.66059E-05	0	0	0	None	0	0	1.59157E-06	0	0	0	None	N	None
8605	57	A/T	None	0.0914	gnomAD-4.0.0	136	None	0.5346	0.4889	24.7	N	None	1.01	0.020371	-1.339	0.2773	-0.5282	0.457598942377	None	0.996069	0.508	0.212008924253	1.0	0.518440008163	-2.21	0.353	0.709	0.415	None	None	1.59158E-06	0	0	0	0	None	0	0	1.59158E-06	2.8591E-06	0	0	None	N	None
8606	58	V/G	rs747173071	0.1386	gnomAD-2.1.1	137	None	0.3193	0.3132	24.9	N	-2.934	-0.23	0.035577	-2.56	0.3942	-0.1906	0.403457794327	None	0.999147	0.486	0.851354784354	0.91	0.289550870657	-4.0	0.362	0.714	0.006	None	None	8.04E-06	6.46E-05	0	0	0	None	3.27E-05	None	8.04E-06	0	0	0	None	N	None
8606	58	V/G	rs747173071	0.1386	gnomAD-4.0.0	137	None	0.3193	0.3132	24.9	N	-2.934	-0.23	0.035577	-2.56	0.3942	-0.1906	0.403457794327	None	0.999147	0.486	0.851354784354	0.91	0.289550870657	-4.0	0.362	0.714	0.006	None	None	1.59157E-06	0	0	0	0	None	0	0	1.59157E-06	0	1.43283E-05	0	None	N	None
8606	58	V/L	None	0.1386	gnomAD-4.0.0	137	None	0.1374	0.1237	16.77	N	None	-0.22	0.039072	-0.78	0.2169	-0.7565	0.0873067246891	None	1.0	0.464	0.366466682447	0.005	0.345137238503	-1.45	0.099	0.49	0.129	None	None	6.84269E-07	0	0	0	0	None	0	0	6.84269E-07	8.99544E-07	0	0	None	N	None
8606	58	V/M	rs1453874617	0.1386	gnomAD-2.1.1	137	None	0.0983	0.0936	21.5	N	-0.724	-0.26	0.055298	-0.82	0.4425	-0.0636	0.317607766921	None	1.0	0.504	0.490419987736	0.664	0.367198556662	-1.55	0.308	0.647	0.086	None	None	4.02E-06	0	0	0	5.57E-05	None	0	None	4.02E-06	0	0	0	None	N	None
8606	58	V/M	rs1453874617	0.1386	gnomAD-4.0.0	137	None	0.0983	0.0936	21.5	N	-0.724	-0.26	0.055298	-0.82	0.4425	-0.0636	0.317607766921	None	1.0	0.504	0.490419987736	0.664	0.367198556662	-1.55	0.308	0.647	0.086	None	None	6.84269E-07	0	0	0	2.51965E-05	None	0	0	6.84269E-07	0	0	0	None	N	None
8607	59	L/P	rs780404365	0.0723	gnomAD-2.1.1	138	None	0.9912	0.9889	24.8	D	-1.635	-0.75	0.084533	-1.461	0.7602	0.873	0.58505323944	None	0.999777	0.855	0.895674922005	1.0	0.520051002502	-3.98	0.841	0.924	0.002	None	None	4.02E-06	0	0	0	5.57E-05	None	0	None	4.02E-06	0	0	0	None	N	None
8607	59	L/R	None	0.0723	gnomAD-4.0.0	138	None	0.9656	0.9577	24.7	D	None	-0.75	0.093139	-2.17	0.7579	0.8696	0.552897332157	None	1.0	0.867	0.876399648183	0.999	0.487095624208	-3.47	0.831	0.918	0.001	None	None	1.59155E-06	0	0	0	0	None	0	0	1.59155E-06	2.85901E-06	0	0	None	N	None
8608	60	E/A	None	0.2570	gnomAD-4.0.0	139	None	0.3068	0.3048	27.8	N	None	-0.25	0.040392	-1.36	0.43	-0.0838	0.405264810626	None	0.782551	0.477	0.476051820916	0.987	0.492712020874	-3.61	0.409	0.521	0.272	None	None	6.84262E-07	0	0	0	0	None	0	0	6.84262E-07	8.99536E-07	0	0	None	N	None
8608	60	E/G	None	0.2570	gnomAD-4.0.0	139	None	0.456	0.4695	29.2	D	None	-0.3	0.058061	-1.78	0.5463	0.3179	0.445162184416	None	0.812176	0.534	0.582764979894	0.998	0.457301318645	-4.33	0.508	0.615	0.11	None	None	6.84262E-07	0	0	0	0	None	0	0	6.84262E-07	8.99536E-07	0	0	None	N	None
8609	61	M/I	rs1407524421	0.0744	gnomAD-4.0.0	140	None	0.3643	0.3724	22.1	N	None	0.78	0.014788	-0.32	0.0379	-1.0218	0.0925954833539	None	1.0	0.547	0.221019684889	None	0.441253602505	-1.54	0.222	0.279	1.0	None	None	2.05282E-06	0	0	0	0	None	0	0	2.05282E-06	2.69863E-06	0	0	None	N	None
8609	61	M/V	rs1369418506	0.0744	gnomAD-3.1.2	140	None	0.2005	0.1926	22.2	N	None	-0.12	0.039887	-0.747	0.1036	-1.0381	0.0845940308932	None	1.0	0.537	0.377274123778	None	0.397946953773	-1.71	0.11	0.273	0.4	None	None	6.57E-06	0	0	0	1.9305E-04	None	0	0	6.57E-06	0	0	0	None	N	None
8609	61	M/V	rs1369418506	0.0744	gnomAD-4.0.0	140	None	0.2005	0.1926	22.2	N	None	-0.12	0.039887	-0.747	0.1036	-1.0381	0.0845940308932	None	1.0	0.537	0.377274123778	None	0.397946953773	-1.71	0.11	0.273	0.4	None	None	6.57445E-06	0	0	0	1.9305E-04	None	0	0	6.57445E-06	0	0	0	None	N	None
8610	62	H/P	None	0.2877	gnomAD-4.0.0	141	None	0.2771	0.296	18.93	N	None	-0.21	0.046599	-0.504	0.1797	-0.8778	0.152160586379	None	1.0	0.406	0.241078983079	0.065	0.368356883526	-4.68	0.138	0.47	0.066	None	None	6.84261E-07	0	0	0	0	None	0	0	6.84261E-07	8.99544E-07	0	0	None	N	None
8610	62	H/Q	rs200939405	0.2877	gnomAD-2.1.1	141	None	0.102	0.1064	18.12	N	-0.817	-0.1	0.019676	-0.74	0.1339	-0.9653	0.0842887182597	None	1.0	0.338	0.0716867268079	0.001	0.377162724733	-3.41	0.061	0.128	0.093	None	None	3.21E-05	3.72178E-04	0	0	0	None	0	None	3.21E-05	0	0	0	None	N	None
8610	62	H/Q	rs200939405	0.2877	gnomAD-3.1.2	141	None	0.102	0.1064	18.12	N	-0.817	-0.1	0.019676	-0.74	0.1339	-0.9653	0.0842887182597	None	1.0	0.338	0.0716867268079	0.001	0.377162724733	-3.41	0.061	0.128	0.093	None	None	5.92E-05	2.17412E-04	0	0	0	None	0	0	5.92E-05	0	0	0	None	N	None
8610	62	H/Q	rs200939405	0.2877	gnomAD-4.0.0	141	None	0.102	0.1064	18.12	N	-0.817	-0.1	0.019676	-0.74	0.1339	-0.9653	0.0842887182597	None	1.0	0.338	0.0716867268079	0.001	0.377162724733	-3.41	0.061	0.128	0.093	None	None	8.67733E-06	1.87041E-04	0	0	0	None	0	0	8.67733E-06	0	0	0	None	N	None
8610	62	H/R	rs561059250	0.2877	gnomAD-2.1.1	141	None	0.0702	0.0725	17.76	N	-1.125	-0.15	0.021641	-1.182	0.098	-1.0114	0.102109692454	None	1.0	0.317	0.101711395817	None	0.394649893045	-3.75	0.068	0.101	0.105	None	None	3.57E-05	0	0	0	3.5868E-04	None	0	None	3.57E-05	0	0	4.21822E-04	None	N	None
8610	62	H/R	rs561059250	0.2877	gnomAD-3.1.2	141	None	0.0702	0.0725	17.76	N	-1.125	-0.15	0.021641	-1.182	0.098	-1.0114	0.102109692454	None	1.0	0.317	0.101711395817	None	0.394649893045	-3.75	0.068	0.101	0.105	None	None	3.29E-05	0	6.55E-05	0	7.72798E-04	None	0	0	3.29E-05	0	0	0	None	N	None
8610	62	H/R	rs561059250	0.2877	1000 genomes	141	None	0.0702	0.0725	17.76	N	-1.125	-0.15	0.021641	-1.182	0.098	-1.0114	0.102109692454	None	1.0	0.317	0.101711395817	None	0.394649893045	-3.75	0.068	0.101	0.105	None	None	1.99681E-04	0	0	None	1E-03	0	None	None	1.99681E-04	None	0	None	None	N	None
8610	62	H/R	rs561059250	0.2877	gnomAD-4.0.0	141	None	0.0702	0.0725	17.76	N	-1.125	-0.15	0.021641	-1.182	0.098	-1.0114	0.102109692454	None	1.0	0.317	0.101711395817	None	0.394649893045	-3.75	0.068	0.101	0.105	None	None	1.98311E-05	1.33312E-05	1.66683E-05	0	2.00651E-04	None	0	0	1.98311E-05	5.9339E-06	0	2.24122E-04	None	N	None
8611	63	N/K	None	0.7793	gnomAD-4.0.0	143	None	0.125	0.1344	16.24	N	None	0.89	0.007733	-0.177	0.0702	-0.9536	0.10191099433	None	1.0	0.648	0.0138822411134	0.022	0.247639536858	-2.8	0.08	0.153	0.235	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	0	0	3.66327E-05	None	N	None
8611	63	N/S	rs779262321	0.7793	gnomAD-2.1.1	143	None	0.0629	0.0588	11.81	N	-0.664	0.9	0.006757	-0.41	0.0628	-0.9672	0.0672008464947	None	1.0	0.513	0.0138822411134	None	0.210371106863	-1.58	0.121	0.111	0.296	None	None	1.21E-05	0	0	0	1.67056E-04	None	0	None	1.21E-05	0	0	0	None	N	None
8611	63	N/S	rs779262321	0.7793	gnomAD-3.1.2	143	None	0.0629	0.0588	11.81	N	-0.664	0.9	0.006757	-0.41	0.0628	-0.9672	0.0672008464947	None	1.0	0.513	0.0138822411134	None	0.210371106863	-1.58	0.121	0.111	0.296	None	None	6.58E-06	0	0	0	1.93349E-04	None	0	0	6.58E-06	0	0	0	None	N	None
8611	63	N/S	rs779262321	0.7793	gnomAD-4.0.0	143	None	0.0629	0.0588	11.81	N	-0.664	0.9	0.006757	-0.41	0.0628	-0.9672	0.0672008464947	None	1.0	0.513	0.0138822411134	None	0.210371106863	-1.58	0.121	0.111	0.296	None	None	2.16925E-05	0	0	0	6.46427E-04	None	0	0	2.16925E-05	5.08625E-06	0	0	None	N	None
8612	64	L/F	rs755695660	0.1135	gnomAD-2.1.1	144	None	0.446	0.4632	22.2	N	-1.757	-0.33	0.019413	-1.683	0.3238	-0.3278	0.270781986263	None	1.0	0.463	0.592743537544	0.97	0.28230074048	-2.2	0.2	0.605	0.069	None	None	4.02E-06	0	2.9E-05	0	0	None	0	None	4.02E-06	0	0	0	None	N	None
8612	64	L/F	rs755695660	0.1135	gnomAD-3.1.2	144	None	0.446	0.4632	22.2	N	-1.757	-0.33	0.019413	-1.683	0.3238	-0.3278	0.270781986263	None	1.0	0.463	0.592743537544	0.97	0.28230074048	-2.2	0.2	0.605	0.069	None	None	6.58E-06	0	6.55E-05	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
8612	64	L/F	rs755695660	0.1135	gnomAD-4.0.0	144	None	0.446	0.4632	22.2	N	-1.757	-0.33	0.019413	-1.683	0.3238	-0.3278	0.270781986263	None	1.0	0.463	0.592743537544	0.97	0.28230074048	-2.2	0.2	0.605	0.069	None	None	1.85944E-06	0	3.33478E-05	0	0	None	0	0	1.85944E-06	8.47725E-07	0	0	None	N	None
8612	64	L/R	rs1345942434	0.1135	gnomAD-3.1.2	144	None	0.7792	0.7924	23.3	N	None	-0.35	0.075054	-1.439	0.3996	-0.186	0.486763637979	None	1.0	0.617	0.829248476454	0.999	0.324449032545	-3.42	0.5	0.618	0.052	None	None	6.58E-06	2.42E-05	0	0	0	None	0	0	6.58E-06	0	0	0	None	N	None
8612	64	L/R	rs1345942434	0.1135	gnomAD-4.0.0	144	None	0.7792	0.7924	23.3	N	None	-0.35	0.075054	-1.439	0.3996	-0.186	0.486763637979	None	1.0	0.617	0.829248476454	0.999	0.324449032545	-3.42	0.5	0.618	0.052	None	None	6.58155E-06	2.41674E-05	0	0	0	None	0	0	6.58155E-06	0	0	0	None	N	None
8613	65	S/R	None	0.1551	gnomAD-4.0.0	145	None	0.1999	0.2082	18.74	N	None	-0.25	0.025084	-0.557	0.1699	-1.0248	0.101712387073	None	1.0	0.363	0.0716867268079	0.023	0.359436035156	-2.17	0.069	0.251	0.143	None	None	6.84264E-07	0	0	0	0	None	0	0	6.84264E-07	8.99543E-07	0	0	None	N	None
8614	66	V/A	None	0.5102	gnomAD-4.0.0	146	None	0.1166	0.1102	22.7	N	None	1.03	0.013728	-0.706	0.0929	-1.0009	0.145469751178	None	1.0	0.367	0.220303561663	0.202	0.436107873917	-2.18	0.072	0.175	0.422	None	None	1.59153E-06	0	0	0	0	None	0	0	1.59153E-06	0	1.43283E-05	0	None	I	None
8615	67	E/D	rs758944073	0.4075	gnomAD-2.1.1	148	None	0.1057	0.1017	22.0	N	0.148	0.9	0.018351	-0.179	0.0893	-1.0505	0.0759694062594	None	1.0	0.422	0.0666544352282	0.001	0.44120401144	-1.27	0.139	0.147	0.426	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	4.65E-05	0	0	None	N	None
8615	67	E/D	rs758944073	0.4075	gnomAD-4.0.0	148	None	0.1057	0.1017	22.0	N	0.148	0.9	0.018351	-0.179	0.0893	-1.0505	0.0759694062594	None	1.0	0.422	0.0666544352282	0.001	0.44120401144	-1.27	0.139	0.147	0.426	None	None	6.84269E-07	0	0	0	0	None	1.87308E-05	0	6.84269E-07	0	0	0	None	N	None
8617	69	S/I	None	0.2064	gnomAD-4.0.0	151	None	0.4836	0.4452	22.7	D	None	-0.41	0.059858	-0.226	0.3984	-0.0232	0.242440161284	None	1.0	0.438	0.732098058403	0.84	0.462007671595	-3.42	0.359	0.572	0.011	None	None	1.5916E-06	0	0	0	0	None	0	0	1.5916E-06	2.85914E-06	0	0	None	N	None
8617	69	S/N	rs1361559046	0.2064	gnomAD-2.1.1	151	None	0.3704	0.3239	22.1	N	-0.497	-0.37	0.038166	-0.532	0.3333	-0.4322	0.0781518737448	None	1.0	0.351	0.213573922156	0.001	0.48137742281	-1.31	0.173	0.198	0.157	None	None	8.05E-06	0	0	0	0	None	0	None	8.05E-06	0	1.78E-05	0	None	N	None
8617	69	S/N	rs1361559046	0.2064	gnomAD-4.0.0	151	None	0.3704	0.3239	22.1	N	-0.497	-0.37	0.038166	-0.532	0.3333	-0.4322	0.0781518737448	None	1.0	0.351	0.213573922156	0.001	0.48137742281	-1.31	0.173	0.198	0.157	None	None	6.36641E-06	0	0	0	2.77316E-05	None	0	0	6.36641E-06	8.57741E-06	0	0	None	N	None
8618	70	G/E	rs369947439	0.1662	gnomAD-2.1.1	152	None	0.9324	0.85	None	D	-1.317	None	None	-1.204	None	None	None	None	None	None	None	1.0	None	None	0.771	0.849	None	None	None	4.42E-05	0	2.03004E-04	0	0	None	0	None	4.42E-05	0	3.56E-05	0	None	N	None
8618	70	G/E	rs369947439	0.1662	gnomAD-3.1.2	152	None	0.9324	0.85	None	D	-1.317	None	None	-1.204	None	None	None	None	None	None	None	1.0	None	None	0.771	0.849	None	None	None	6.58E-05	2.42E-05	3.93804E-04	0	0	None	0	0	6.58E-05	2.94E-05	0	4.78927E-04	None	N	None
8618	70	G/E	rs369947439	0.1662	gnomAD-4.0.0	152	None	0.9324	0.85	None	D	-1.317	None	None	-1.204	None	None	None	None	None	None	None	1.0	None	None	0.771	0.849	None	None	None	4.89647E-05	1.33586E-05	3.0028E-04	0	0	None	0	0	4.89647E-05	4.66252E-05	0	8.00641E-05	None	N	None
8619	71	D/G	rs2077359221	0.5818	gnomAD-4.0.0	153	None	0.3554	0.2363	28.9	N	None	-0.27	0.04336	-0.683	0.4126	-0.0766	0.362238719904	None	0.581191	0.45	0.341696514166	0.95	0.421999394894	-3.91	0.361	0.512	0.204	None	None	4.10566E-06	0	0	0	0	None	0	3.47102E-04	4.10566E-06	3.59823E-06	0	0	None	N	None
8620	72	Y/C	None	0.1129	gnomAD-4.0.0	154	None	0.8165	0.6621	28.5	D	None	-1.28	0.192754	-2.018	0.8028	0.914	0.517873433737	None	0.982604	0.759	0.87617659604	1.0	0.653878569603	-6.08	0.872	0.873	0.003	None	None	1.59163E-06	0	0	0	0	None	0	0	1.59163E-06	2.85917E-06	0	0	None	N	None
8621	73	T/I	None	0.2119	gnomAD-4.0.0	155	None	0.1386	0.1038	24.4	N	None	0.81	0.013202	-0.311	0.2426	-0.6443	0.464258406265	None	0.76619	0.517	0.406668915854	0.998	0.38403865695	-3.64	0.229	0.763	0.164	None	None	6.84286E-07	0	0	0	0	None	0	0	6.84286E-07	8.9957E-07	0	0	None	N	None
8621	73	T/N	rs899151063	0.2119	gnomAD-2.1.1	155	None	0.2526	0.2491	23.9	N	-1.338	0.75	0.015517	-0.92	0.3789	-0.0081	0.407989511232	None	0.757778	0.528	0.381071309025	0.98	0.355875074863	-2.91	0.314	0.72	0.013	None	None	8.05E-06	0	0	0	0	None	0	None	8.05E-06	0	1.78E-05	0	None	N	None
8621	73	T/N	rs899151063	0.2119	gnomAD-3.1.2	155	None	0.2526	0.2491	23.9	N	-1.338	0.75	0.015517	-0.92	0.3789	-0.0081	0.407989511232	None	0.757778	0.528	0.381071309025	0.98	0.355875074863	-2.91	0.314	0.72	0.013	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	N	None
8621	73	T/N	rs899151063	0.2119	gnomAD-4.0.0	155	None	0.2526	0.2491	23.9	N	-1.338	0.75	0.015517	-0.92	0.3789	-0.0081	0.407989511232	None	0.757778	0.528	0.381071309025	0.98	0.355875074863	-2.91	0.314	0.72	0.013	None	None	4.33843E-06	0	0	0	0	None	0	0	4.33843E-06	5.93395E-06	0	0	None	N	None
8622	74	C/Y	None	0.0686	gnomAD-4.0.0	156	None	0.9896	0.9809	25.2	D	None	-0.12	0.096924	-1.149	0.6638	0.7092	0.600679684098	None	0.999124	0.811	0.818437442364	1.0	0.765983343124	-7.18	0.639	0.905	0.004	None	None	1.59168E-06	0	0	0	0	None	0	0	1.59168E-06	2.85932E-06	0	0	disulfide	N	None
8623	75	E/D	None	0.3260	gnomAD-4.0.0	157	None	0.5638	0.5355	23.7	N	None	-0.29	0.033454	-1.458	0.4314	-0.0374	0.311127735003	None	1.0	0.395	0.36453787251	0.969	0.503363549709	-1.67	0.325	0.508	0.026	None	None	1.36861E-06	0	0	0	0	None	0	0	1.36861E-06	1.79919E-06	0	0	None	N	None
8623	75	E/G	rs766190373	0.3260	gnomAD-2.1.1	157	None	0.6709	0.6183	32.0	D	-1.849	-0.31	0.083895	-1.405	0.5743	0.4295	0.44134038575	None	0.570942	0.396	0.65995756008	0.998	0.463029533625	-4.05	0.478	0.681	0.004	None	None	4.02E-06	0	0	0	0	None	0	None	4.02E-06	0	8.9E-06	0	None	N	None
8626	78	N/D	rs2077357318	0.1657	gnomAD-3.1.2	161	None	0.9505	0.939	26.0	D	None	0.28	0.07573	-1.421	0.5989	0.6065	0.491690686565	None	0.778932	0.836	0.377274123778	0.996	0.617975354195	-3.07	0.576	0.624	0.218	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	N	None
8626	78	N/D	rs2077357318	0.1657	gnomAD-4.0.0	161	None	0.9505	0.939	26.0	D	None	0.28	0.07573	-1.421	0.5989	0.6065	0.491690686565	None	0.778932	0.836	0.377274123778	0.996	0.617975354195	-3.07	0.576	0.624	0.218	None	None	6.57177E-06	0	0	0	0	None	0	0	6.57177E-06	1.47003E-05	0	0	None	N	None
8626	78	N/S	rs200355367	0.1657	gnomAD-2.1.1	161	None	0.4105	0.3313	None	N	-0.897	None	None	-0.956	None	None	None	None	None	None	None	0.996	None	None	0.485	0.591	None	None	None	1.21503E-04	4.13E-05	0	0	0	None	0	None	1.21503E-04	0	2.5826E-04	0	None	N	None
8626	78	N/S	rs200355367	0.1657	gnomAD-3.1.2	161	None	0.4105	0.3313	None	N	-0.897	None	None	-0.956	None	None	None	None	None	None	None	0.996	None	None	0.485	0.591	None	None	None	1.70882E-04	2.41E-05	0	0	1.9253E-04	None	0	0	1.70882E-04	3.23463E-04	2.07641E-04	4.77555E-04	None	N	None
8626	78	N/S	rs200355367	0.1657	gnomAD-4.0.0	161	None	0.4105	0.3313	None	N	-0.897	None	None	-0.956	None	None	None	None	None	None	None	0.996	None	None	0.485	0.591	None	None	None	3.26633E-04	4.00588E-05	0	0	6.6839E-05	None	0	0	3.26633E-04	4.17945E-04	4.39261E-05	3.84418E-04	None	N	None
8627	79	A/V	rs1349154909	0.7380	gnomAD-2.1.1	162	None	0.0845	0.0839	23.8	N	-0.088	-0.29	0.022081	-0.389	0.2182	-0.7665	0.0836596880084	None	1.0	0.353	0.431490205687	0.008	0.425386071205	-1.89	0.169	0.202	0.261	None	None	3.19E-05	0	0	0	0	None	0	None	3.19E-05	0	6.48E-05	0	None	I	None
8627	79	A/V	rs1349154909	0.7380	gnomAD-3.1.2	162	None	0.0845	0.0839	23.8	N	-0.088	-0.29	0.022081	-0.389	0.2182	-0.7665	0.0836596880084	None	1.0	0.353	0.431490205687	0.008	0.425386071205	-1.89	0.169	0.202	0.261	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	I	None
8627	79	A/V	rs1349154909	0.7380	gnomAD-4.0.0	162	None	0.0845	0.0839	23.8	N	-0.088	-0.29	0.022081	-0.389	0.2182	-0.7665	0.0836596880084	None	1.0	0.353	0.431490205687	0.008	0.425386071205	-1.89	0.169	0.202	0.261	None	None	2.02993E-06	0	0	0	0	None	0	0	2.02993E-06	2.40985E-06	0	0	None	I	None
8628	80	A/V	None	0.7239	gnomAD-4.0.0	163	None	0.1072	0.1049	23.4	N	None	-0.24	0.022969	-0.312	0.2194	-0.5957	0.122612874702	None	0.911058	0.555	0.434272847907	0.682	0.530208230019	-2.43	0.25	0.495	0.426	None	None	1.59257E-06	0	0	0	0	None	0	0	1.59257E-06	2.86157E-06	0	0	None	I	None
8629	81	G/S	rs2077356013	0.3170	gnomAD-3.1.2	164	None	0.6248	0.4783	23.7	D	None	-0.83	0.035775	-0.552	0.7125	0.6608	0.462948729789	None	0.999134	0.832	0.555237559564	1.0	0.577521979809	-3.74	0.813	0.803	0.191	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	0	2.07211E-04	0	None	I	None
8629	81	G/S	rs2077356013	0.3170	gnomAD-4.0.0	164	None	0.6248	0.4783	23.7	D	None	-0.83	0.035775	-0.552	0.7125	0.6608	0.462948729789	None	0.999134	0.832	0.555237559564	1.0	0.577521979809	-3.74	0.813	0.803	0.191	None	None	6.57479E-06	0	0	0	0	None	0	0	6.57479E-06	0	2.07211E-04	0	None	I	None
8629	81	G/V	None	0.3170	gnomAD-4.0.0	164	None	0.9566	0.9164	24.8	D	None	-0.9	0.104903	-0.435	0.7837	0.9138	0.518063289252	None	1.0	0.876	0.942225882153	1.0	0.585615634918	-5.56	0.828	0.837	0.03	None	None	1.59355E-06	0	0	0	2.77393E-05	None	0	0	1.59355E-06	0	0	0	None	I	None
8630	82	S/C	None	0.5445	gnomAD-4.0.0	165	None	0.2037	0.1364	23.8	N	None	-0.37	0.031983	-0.318	0.3776	-0.1545	0.281943473049	None	0.97467	0.461	0.564651752942	0.977	0.475824177265	-3.15	0.383	0.611	0.005	None	None	1.20032E-06	0	0	0	0	None	0	0	1.20032E-06	1.3125E-06	0	0	None	I	None
8631	83	A/T	rs769720173	0.2198	gnomAD-2.1.1	166	None	0.1135	0.0893	22.9	D	-0.694	-0.36	0.026452	-0.852	0.2684	-0.5072	0.112108087553	None	1.0	0.438	0.318828661733	0.483	0.442332327366	-1.96	0.208	0.492	0.118	None	None	2.42E-05	0	0	0	3.3415E-04	None	0	None	2.42E-05	0	0	0	None	N	None
8631	83	A/T	rs769720173	0.2198	gnomAD-3.1.2	166	None	0.1135	0.0893	22.9	D	-0.694	-0.36	0.026452	-0.852	0.2684	-0.5072	0.112108087553	None	1.0	0.438	0.318828661733	0.483	0.442332327366	-1.96	0.208	0.492	0.118	None	None	6.57E-06	0	0	0	1.92753E-04	None	0	0	6.57E-06	0	0	0	None	N	None
8631	83	A/T	rs769720173	0.2198	gnomAD-4.0.0	166	None	0.1135	0.0893	22.9	D	-0.694	-0.36	0.026452	-0.852	0.2684	-0.5072	0.112108087553	None	1.0	0.438	0.318828661733	0.483	0.442332327366	-1.96	0.208	0.492	0.118	None	None	8.98124E-06	0	0	0	1.69779E-04	None	0	0	8.98124E-06	0	0	0	None	N	None
8632	84	S/G	None	0.4102	gnomAD-4.0.0	168	None	0.1364	0.1335	23.7	D	None	-0.35	0.034199	-0.789	0.5372	0.3189	0.363869704645	None	1.0	0.39	0.388812400583	0.997	0.474593818188	-2.54	0.368	0.434	0.06	None	None	2.40064E-06	0	0	0	0	None	0	0	2.40064E-06	2.625E-06	0	0	None	N	None
8633	85	S/G	rs776980958	0.1218	gnomAD-2.1.1	169	None	0.1932	0.1525	23.6	N	-1.412	-0.34	0.036571	-1.208	0.2335	-0.5962	0.143767449936	None	1.0	0.446	0.21279746466	0.606	0.379890799522	-2.33	0.164	0.501	0.165	None	None	4.03E-06	0	0	0	0	None	0	None	4.03E-06	0	8.92E-06	0	None	N	None
8633	85	S/G	rs776980958	0.1218	gnomAD-4.0.0	169	None	0.1932	0.1525	23.6	N	-1.412	-0.34	0.036571	-1.208	0.2335	-0.5962	0.143767449936	None	1.0	0.446	0.21279746466	0.606	0.379890799522	-2.33	0.164	0.501	0.165	None	None	1.59484E-06	0	0	0	0	None	0	0	1.59484E-06	2.86788E-06	0	0	None	N	None
8634	86	S/C	rs769050572	0.3693	gnomAD-2.1.1	171	None	0.2948	0.2246	25.4	D	-0.212	-0.4	0.076492	-0.334	0.4831	0.2209	0.244918179632	None	0.903204	0.529	0.628150982837	0.827	0.53346991539	-3.15	0.519	0.771	0.065	None	None	1.21E-05	0	0	0	1.67094E-04	None	0	None	1.21E-05	0	0	0	None	N	None
8634	86	S/C	rs769050572	0.3693	gnomAD-3.1.2	171	None	0.2948	0.2246	25.4	D	-0.212	-0.4	0.076492	-0.334	0.4831	0.2209	0.244918179632	None	0.903204	0.529	0.628150982837	0.827	0.53346991539	-3.15	0.519	0.771	0.065	None	None	6.57E-06	0	0	0	1.92678E-04	None	0	0	6.57E-06	0	0	0	None	N	None
8634	86	S/C	rs769050572	0.3693	gnomAD-4.0.0	171	None	0.2948	0.2246	25.4	D	-0.212	-0.4	0.076492	-0.334	0.4831	0.2209	0.244918179632	None	0.903204	0.529	0.628150982837	0.827	0.53346991539	-3.15	0.519	0.771	0.065	None	None	3.10148E-06	0	0	0	1.11488E-04	None	0	0	3.10148E-06	0	0	0	None	N	None
8635	87	T/A	None	0.1054	gnomAD-4.0.0	172	None	0.0927	0.0875	24.1	N	None	0.03	0.02434	-1.395	0.2068	-0.6295	0.29134603975	None	0.717533	0.315	0.220303561663	0.934	0.395427882671	-2.35	0.154	0.572	0.46	None	None	1.20039E-06	0	0	0	0	None	0	0	1.20039E-06	1.31256E-06	0	0	None	N	None
8635	87	T/I	rs1005082166	0.1054	gnomAD-3.1.2	172	None	0.2262	0.2438	27.2	N	None	-0.14	0.018023	-0.555	0.3803	-0.2943	0.480749730577	None	0.801748	0.401	0.475192790171	1.0	0.503158330917	-3.38	0.315	0.825	0.086	None	None	6.57E-06	2.41E-05	0	0	0	None	0	0	6.57E-06	0	0	0	None	N	None
8635	87	T/I	rs1005082166	0.1054	gnomAD-4.0.0	172	None	0.2262	0.2438	27.2	N	None	-0.14	0.018023	-0.555	0.3803	-0.2943	0.480749730577	None	0.801748	0.401	0.475192790171	1.0	0.503158330917	-3.38	0.315	0.825	0.086	None	None	1.24085E-06	1.33636E-05	0	0	0	None	0	0	1.24085E-06	8.48675E-07	0	0	None	N	None
8636	88	S/A	rs1448059327	0.2637	gnomAD-2.1.1	173	None	0.068	0.0664	20.1	N	-0.887	-0.33	0.024253	-0.804	0.1614	-0.8865	0.0701758770016	None	1.0	0.408	0.0884992946249	None	0.390433847904	-1.29	0.069	0.137	0.318	None	None	4.04E-06	0	0	0	0	None	0	None	4.04E-06	0	8.94E-06	0	None	N	None
8636	88	S/A	rs1448059327	0.2637	gnomAD-4.0.0	173	None	0.068	0.0664	20.1	N	-0.887	-0.33	0.024253	-0.804	0.1614	-0.8865	0.0701758770016	None	1.0	0.408	0.0884992946249	None	0.390433847904	-1.29	0.069	0.137	0.318	None	None	1.59608E-06	0	0	0	0	None	0	0	1.59608E-06	2.87054E-06	0	0	None	N	None
8636	88	S/T	rs1448059327	0.2637	gnomAD-2.1.1	173	None	0.0812	0.0767	19.08	N	-0.403	-0.26	0.022209	-0.613	0.1503	-0.9135	0.0763001356589	None	1.0	0.405	0.0806252709748	None	0.406102508307	-1.42	0.089	0.147	0.257	None	None	3.19E-05	0	0	0	0	None	0	None	3.19E-05	0	6.48E-05	0	None	N	None
8636	88	S/T	rs1448059327	0.2637	gnomAD-3.1.2	173	None	0.0812	0.0767	19.08	N	-0.403	-0.26	0.022209	-0.613	0.1503	-0.9135	0.0763001356589	None	1.0	0.405	0.0806252709748	None	0.406102508307	-1.42	0.089	0.147	0.257	None	None	6.57E-06	0	0	0	0	None	0	0	6.57E-06	1.47E-05	0	0	None	N	None
8636	88	S/T	rs1448059327	0.2637	gnomAD-4.0.0	173	None	0.0812	0.0767	19.08	N	-0.403	-0.26	0.022209	-0.613	0.1503	-0.9135	0.0763001356589	None	1.0	0.405	0.0806252709748	None	0.406102508307	-1.42	0.089	0.147	0.257	None	None	3.85262E-06	0	0	0	0	None	0	0	3.85262E-06	7.20458E-06	0	0	None	N	None
8638	90	K/N	None	0.6783	gnomAD-4.0.0	175	None	0.4627	0.381	20.8	N	None	-0.33	0.035508	-0.201	0.1805	-0.8578	0.126996411083	None	1.0	0.479	0.197625483188	0.447	0.511605501175	-2.06	0.059	0.275	0.192	None	None	1.59765E-06	0	0	0	0	None	0	0	1.59765E-06	2.87396E-06	0	0	None	N	None
8639	91	V/I	rs1427227571	0.1162	gnomAD-2.1.1	177	None	0.1162	0.1106	22.1	N	None	-0.82	0.032366	-0.971	0.4176	-0.3464	0.0761191393141	None	1.0	0.7	0.430239905395	0.012	0.409758687019	-0.52	0.369	0.481	0.144	None	None	4.05E-06	0	0	0	0	None	0	None	4.05E-06	0	8.97E-06	0	None	N	None
8639	91	V/I	rs1427227571	0.1162	gnomAD-4.0.0	177	None	0.1162	0.1106	22.1	N	None	-0.82	0.032366	-0.971	0.4176	-0.3464	0.0761191393141	None	1.0	0.7	0.430239905395	0.012	0.409758687019	-0.52	0.369	0.481	0.144	None	None	1.371E-06	0	0	0	2.52283E-05	None	0	0	1.371E-06	9.01115E-07	0	0	None	N	None

Whole Population MAF	African (AFR)	Latin American (AMR)
Amish (AMS)	Ashkenazi Jewish (ASJ)	East Asian (EAS)
European/1KGP (EUR)	Finnish (FIN)	Middle Eastern (MDE)
Non-Finnish European (NFE)	South Asian (SAS)	Other (OTH)

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