Select a Data Table to View:



Download domain sequence (FASTA)
Export SAV table to CSV

Select columns to include

Basic Information

SAV Position Domain position
RS Q(SASA) Source Structural position

Pathogenicity / Stability Predictions

AlphaMissense (IC) AlphaMissense (N2AB)
CADD Condel DUET FATHMM M-CAP
mCSM MetaLR MetaSVM MPC MutationAssessor
MutationTaster MutPred MVP PolyPhen-2
PrimateAI PROVEAN REVEL Rhapsody SIFT

Disease Associations

Disease Zygosity Comments

Population Frequencies

Whole Population MAF African (AFR) Latin American (AMR)
Amish (AMS) Ashkenazi Jewish (ASJ) East Asian (EAS)
European/1KGP (EUR) Finnish (FIN) Middle Eastern (MDE)
Non-Finnish European (NFE) South Asian (SAS) Other (OTH)

Other Annotations

Site Annotation Predicted PPI site mCSM-PPI

10 20 30 40 50 60 70 80
V K I I K K P K D V T A L E N A T V A F E V S V S H D T V P V K W F H K S V E I K P S D K H R L V S E R K V H K L M L Q N I S P S D A G E Y T A V V G Q L E C K A K L F V E T L H I T K T M K N I E V P E T K T A S F E C E V S H F N V P S M W L K N G V E I E M S E K F K I V V Q G K L H Q L I I M N T S T E D S A E Y T F V C G N D Q V S A T L T V T P I M I T S M L K D I N A E E K D T I T F E V T V N Y E G I S Y K W L K N G V E I K S T D K C Q M R T K K L T H S L N I R N V H F G D A A D Y T F V A G K A T S T A T L Y V V
V K I I K K P K D V T A L E N A T V A F E V S V S H D T V P V K W F H K S V E I K P S D K H R L V S E R K V H K L M L Q N I S P S D A G E Y T A V V G Q L E C K A K L F - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - V

Map SAVs to Structure

The data displayed in the table aims to be as complete as possible and contains information for all available sources including different versions of the same source, for example, different sources of gnomAD. To avoid seeing multiple entries for the same variant, we recommend to sort by Source first.

Pin SAV
Position
Domain position
SAV
Structural Position
RS
Q(SASA)
Disease
Source
MAF
2797 3 I/S 3 rs1561222466 0.2904 None gnomAD-4.0.0 6.84065E-07
2797 3 I/T 3 rs1561222466 0.2904 None gnomAD-4.0.0 6.84065E-07
2798 4 I/L 4 None 0.4579 None gnomAD-4.0.0 1.20032E-06
2798 4 I/T 4 rs751135365 0.4579 None gnomAD-2.1.1 3.99E-06
2798 4 I/T 4 rs751135365 0.4579 None gnomAD-4.0.0 1.36813E-06
2799 5 K/I 5 None 0.2931 None gnomAD-4.0.0 6.84062E-07
2799 5 K/Q 5 None 0.2931 None gnomAD-4.0.0 1.59047E-06
2799 5 K/R 5 None 0.2931 None gnomAD-4.0.0 6.84062E-07
2800 6 K/R 7 None 0.5232 None gnomAD-4.0.0 1.59048E-06
2801 7 P/Q 8 None 0.1582 None gnomAD-4.0.0 1.59049E-06
2802 8 K/E 9 rs1294814423 0.6735 None gnomAD-2.1.1 3.99E-06
2802 8 K/E 9 rs1294814423 0.6735 None gnomAD-4.0.0 1.59049E-06
2803 9 D/N 11 rs1457989871 0.3636 None gnomAD-2.1.1 3.99E-06
2803 9 D/N 11 rs1457989871 0.3636 None gnomAD-4.0.0 1.20032E-06
2806 12 A/V 16 None 0.1787 None gnomAD-4.0.0 1.20032E-06
2808 14 E/K 23 rs2154342769 0.2784 None gnomAD-4.0.0 1.59048E-06
2809 15 N/K 24 rs762595856 0.4943 None gnomAD-2.1.1 3.99E-06
2809 15 N/K 24 rs762595856 0.4943 None gnomAD-4.0.0 1.59048E-06
2810 16 A/G 25 rs1431193511 0.1381 None gnomAD-2.1.1 3.99E-06
2810 16 A/G 25 rs1431193511 0.1381 None gnomAD-4.0.0 3.18097E-06
2810 16 A/V 25 None 0.1381 None gnomAD-4.0.0 3.18097E-06
2811 17 T/A 26 rs1574566372 0.3228 None gnomAD-4.0.0 1.59047E-06
2812 18 V/I 28 None 0.1729 None gnomAD-4.0.0 1.36812E-06
2812 18 V/L 28 rs146636599 0.1729 None gnomAD-2.1.1 9.56E-05
2812 18 V/L 28 rs146636599 0.1729 None gnomAD-3.1.2 1.44575E-04
2812 18 V/L 28 rs146636599 0.1729 None gnomAD-4.0.0 4.39862E-05
2816 22 V/I 33 None 0.1259 None gnomAD-4.0.0 1.20032E-06
2820 26 H/R 41 rs794729581 0.4181 None gnomAD-2.1.1 3.18E-05
2820 26 H/R 41 rs794729581 0.4181 None gnomAD-3.1.2 1.97E-05
2820 26 H/R 41 rs794729581 0.4181 None gnomAD-4.0.0 6.81517E-06
2821 27 D/E 42 None 0.4075 None gnomAD-4.0.0 1.59048E-06
2821 27 D/Y 42 None 0.4075 None gnomAD-4.0.0 1.59049E-06
2822 28 T/I 43 None 0.9321 None gnomAD-4.0.0 1.36814E-06
2823 29 V/F 44 rs33917087 0.2325 None gnomAD-2.1.1 1.45513E-02
2823 29 V/F 44 rs33917087 0.2325 None gnomAD-3.1.2 1.55706E-02
2823 29 V/F 44 rs33917087 0.2325 None 1000 genomes 7.58786E-03
2823 29 V/F 44 rs33917087 0.2325 None gnomAD-4.0.0 1.85661E-02
2825 31 V/I 46 rs776670775 0.1835 None gnomAD-2.1.1 3.98E-06
2825 31 V/I 46 rs776670775 0.1835 None gnomAD-4.0.0 6.84067E-07
2825 31 V/L 46 None 0.1835 None gnomAD-4.0.0 2.73627E-06
2827 33 W/C 48 None 0.1308 None gnomAD-4.0.0 1.20032E-06
2827 33 W/L 48 None 0.1308 None gnomAD-4.0.0 2.40064E-06
2829 35 H/L 50 rs1272480712 0.1412 None gnomAD-2.1.1 3.98E-06
2829 35 H/L 50 rs1272480712 0.1412 None gnomAD-4.0.0 1.02609E-05
2829 35 H/R 50 None 0.1412 None gnomAD-4.0.0 6.84063E-07
2830 36 K/N 51 rs768672643 0.4033 None gnomAD-2.1.1 3.18E-05
2831 37 S/N 52 rs2306636 0.5624 None gnomAD-2.1.1 7.91051E-02
2831 37 S/N 52 rs2306636 0.5624 None gnomAD-3.1.2 5.16731E-02
2831 37 S/N 52 rs2306636 0.5624 None 1000 genomes 8.127E-02
2831 37 S/N 52 rs2306636 0.5624 None gnomAD-4.0.0 5.47099E-02
2832 38 V/L 55 rs375549179 0.4727 None gnomAD-2.1.1 1.42E-05
2832 38 V/L 55 rs375549179 0.4727 None gnomAD-3.1.2 3.94E-05
2832 38 V/L 55 rs375549179 0.4727 None gnomAD-4.0.0 1.34446E-04
2833 39 E/G 56 None 0.2552 None gnomAD-4.0.0 1.20032E-06
2836 42 P/L 70 rs1310170063 0.5241 None gnomAD-2.1.1 3.98E-06
2836 42 P/L 70 rs1310170063 0.5241 None gnomAD-4.0.0 1.59046E-06
2836 42 P/R 70 rs1310170063 0.5241 None gnomAD-4.0.0 3.18092E-06
2836 42 P/T 70 rs772547332 0.5241 None gnomAD-2.1.1 7.08E-06
2837 43 S/C 73 rs202024134 0.2309 None gnomAD-2.1.1 4.78E-05
2837 43 S/C 73 rs202024134 0.2309 None gnomAD-3.1.2 1.97E-05
2837 43 S/C 73 rs202024134 0.2309 None gnomAD-4.0.0 4.22571E-05
2837 43 S/G 73 rs202024134 0.2309 None gnomAD-2.1.1 3.98E-06
2837 43 S/G 73 rs202024134 0.2309 None gnomAD-4.0.0 3.18094E-06
2837 43 S/R 73 rs1166608062 0.2309 None gnomAD-3.1.2 6.57E-06
2837 43 S/R 73 rs1166608062 0.2309 None gnomAD-4.0.0 6.19566E-06
2840 46 H/R 121 None 0.2557 None gnomAD-4.0.0 1.20032E-06
2841 47 R/K 122 rs779603870 0.5992 None gnomAD-2.1.1 3.98E-06
2841 47 R/K 122 rs779603870 0.5992 None gnomAD-4.0.0 1.36812E-06
2842 48 L/P 123 rs771546584 0.3263 None gnomAD-2.1.1 3.18E-05
2842 48 L/P 123 rs771546584 0.3263 None gnomAD-3.1.2 1.97E-05
2842 48 L/P 123 rs771546584 0.3263 None gnomAD-4.0.0 8.67324E-06
2843 49 V/G 125 None 0.3850 None gnomAD-4.0.0 1.59046E-06
2844 50 S/L 127 rs2091265064 0.4242 None gnomAD-3.1.2 6.57E-06
2844 50 S/L 127 rs2091265064 0.4242 None gnomAD-4.0.0 6.57315E-06
2846 52 R/K 131 rs1658158334 0.5421 None gnomAD-3.1.2 6.57E-06
2846 52 R/K 131 rs1658158334 0.5421 None gnomAD-4.0.0 2.02991E-06
2847 53 K/E 134 rs794729582 0.3375 None gnomAD-2.1.1 3.98E-06
2847 53 K/E 134 rs794729582 0.3375 None gnomAD-4.0.0 2.73624E-06
2848 54 V/L 135 None 0.2644 None gnomAD-4.0.0 1.59046E-06
2849 55 H/N 136 None 0.1596 None gnomAD-4.0.0 1.59046E-06
2849 55 H/Q 136 rs2091263013 0.1596 None gnomAD-4.0.0 1.59045E-06
2850 56 K/R 137 rs1396734796 0.3338 None gnomAD-2.1.1 3.98E-06
2850 56 K/R 137 rs1396734796 0.3338 None gnomAD-4.0.0 1.59045E-06
2852 58 M/I 139 rs1464875201 0.2149 None gnomAD-2.1.1 7.96E-06
2852 58 M/I 139 rs1464875201 0.2149 None gnomAD-3.1.2 6.57E-06
2852 58 M/I 139 rs1464875201 0.2149 None gnomAD-4.0.0 2.56108E-06
2852 58 M/K 139 None 0.2149 None gnomAD-4.0.0 2.40064E-06
2852 58 M/V 139 rs1382675661 0.2149 None gnomAD-2.1.1 3.18E-05
2852 58 M/V 139 rs1382675661 0.2149 None gnomAD-3.1.2 6.57E-06
2852 58 M/V 139 rs1382675661 0.2149 None gnomAD-4.0.0 2.0298E-06
2853 59 L/V 140 rs1379690495 0.1255 None gnomAD-2.1.1 3.98E-06
2853 59 L/V 140 rs1379690495 0.1255 None gnomAD-4.0.0 1.59047E-06
2854 60 Q/H 141 None 0.5121 None gnomAD-4.0.0 6.84063E-07
2854 60 Q/R 141 rs750346528 0.5121 None gnomAD-4.0.0 1.59047E-06
2856 62 I/V 144 rs1387078141 0.0827 None gnomAD-2.1.1 3.18E-05
2856 62 I/V 144 rs1387078141 0.0827 None gnomAD-3.1.2 6.57E-06
2856 62 I/V 144 rs1387078141 0.0827 None gnomAD-4.0.0 5.12232E-06
2857 63 S/C 145 rs1003498795 0.2778 None gnomAD-3.1.2 6.57E-06
2857 63 S/C 145 rs1003498795 0.2778 None gnomAD-4.0.0 1.23913E-06
2857 63 S/F 145 rs1003498795 0.2778 None gnomAD-4.0.0 1.36813E-06
2857 63 S/Y 145 None 0.2778 None gnomAD-4.0.0 4.78845E-06
2858 64 P/L 146 rs370094744 0.4709 None gnomAD-2.1.1 1.42E-05
2858 64 P/L 146 rs370094744 0.4709 None gnomAD-3.1.2 2.63E-05
2858 64 P/L 146 rs370094744 0.4709 None gnomAD-4.0.0 7.435E-06
2858 64 P/R 146 rs370094744 0.4709 None gnomAD-4.0.0 6.84067E-07
2859 65 S/A 148 None 0.5931 None gnomAD-4.0.0 2.40065E-06
2860 66 D/H 149 rs2091257509 0.1882 None gnomAD-3.1.2 1.31E-05
2860 66 D/H 149 rs2091257509 0.1882 None gnomAD-4.0.0 3.04486E-06
2861 67 A/S 151 rs1383547916 0.1911 None gnomAD-3.1.2 1.31E-05
2861 67 A/S 151 rs1383547916 0.1911 None gnomAD-4.0.0 4.05965E-06
2862 68 G/R 152 None 0.1733 None gnomAD-4.0.0 1.59048E-06
2865 71 T/I 155 rs2091254998 0.1268 None gnomAD-4.0.0 2.05219E-06
2865 71 T/R 155 None 0.1268 None gnomAD-4.0.0 6.84064E-07
2866 72 A/T 156 rs147174853 0.1031 None gnomAD-2.1.1 1.59E-05
2866 72 A/T 156 rs147174853 0.1031 None gnomAD-3.1.2 1.97E-05
2866 72 A/T 156 rs147174853 0.1031 None 1000 genomes 1.99681E-04
2866 72 A/T 156 rs147174853 0.1031 None gnomAD-4.0.0 3.71718E-06
2867 73 V/M 157 None 0.1873 None gnomAD-4.0.0 1.20032E-06
2868 74 V/A 158 rs765207321 0.2026 None gnomAD-2.1.1 3.98E-06
2868 74 V/A 158 rs765207321 0.2026 None gnomAD-4.0.0 3.18094E-06
2869 75 G/R 164 rs764173950 0.4096 None gnomAD-2.1.1 2.48E-05
2869 75 G/R 164 rs764173950 0.4096 None gnomAD-3.1.2 1.31E-05
2869 75 G/R 164 rs764173950 0.4096 None gnomAD-4.0.0 8.0546E-06
2869 75 G/V 164 None 0.4096 None gnomAD-4.0.0 1.59046E-06
2870 76 Q/K 165 None 0.8530 None gnomAD-4.0.0 1.59047E-06
2870 76 Q/L 165 rs372008728 0.8530 None gnomAD-2.1.1 7.96E-06
2870 76 Q/L 165 rs372008728 0.8530 None gnomAD-3.1.2 6.57E-06
2870 76 Q/L 165 rs372008728 0.8530 None gnomAD-4.0.0 2.47824E-06
2871 77 L/F 166 None 0.3222 None gnomAD-4.0.0 1.59046E-06
2871 77 L/M 166 None 0.3222 None gnomAD-4.0.0 1.59046E-06
2873 79 C/G 169 None 0.1676 None gnomAD-4.0.0 2.05218E-06
2875 81 A/T 172 rs2091251469 0.0936 None gnomAD-4.0.0 1.20032E-06
2876 82 K/E 173 None 0.2529 None gnomAD-4.0.0 6.84061E-07
2876 82 K/Q 173 None 0.2529 None gnomAD-4.0.0 6.84061E-07
2877 83 L/R 174 None 0.0899 None gnomAD-4.0.0 1.20032E-06
2878 84 F/I 175 rs2091250841 0.3914 None gnomAD-3.1.2 6.57E-06
2878 84 F/I 175 rs2091250841 0.3914 None gnomAD-4.0.0 2.56115E-06
2878 84 F/L 175 None 0.3914 None gnomAD-4.0.0 1.59047E-06
2878 84 F/S 175 rs2091250535 0.3914 None gnomAD-4.0.0 1.36813E-06
2879 85 V/A 177 None 0.6913 None gnomAD-4.0.0 1.59047E-06