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Basic Information

SAV Position Domain position
RS Q(SASA) Source Structural position

Pathogenicity / Stability Predictions

AlphaMissense (IC) AlphaMissense (N2AB)
CADD Condel DUET FATHMM M-CAP
mCSM MetaLR MetaSVM MPC MutationAssessor
MutationTaster MutPred MVP PolyPhen-2
PrimateAI PROVEAN REVEL Rhapsody SIFT

Disease Associations

Disease Zygosity Comments

Population Frequencies

Whole Population MAF African (AFR) Latin American (AMR)
Amish (AMS) Ashkenazi Jewish (ASJ) East Asian (EAS)
European/1KGP (EUR) Finnish (FIN) Middle Eastern (MDE)
Non-Finnish European (NFE) South Asian (SAS) Other (OTH)

Other Annotations

Site Annotation Predicted PPI site mCSM-PPI

10 20 30 40 50 60 70 80 90
L D S E L R K G I V V R A G G S A R I H I P F K G R P T P E I T W S R E E G E F T D K V Q I E K G V N Y T Q L S I D N C D R N D A G K Y I L K L E N S S G S K S A F V T V K V L D T P G P P Q N L A V K E V R K D S A F L V W E P P I I D G G A K V K N Y V I D K R E S T R K A Y A N V S S K C S K T S F K V E N L T E G A I Y Y F R V M A E N E F G V G V P V E T V D A V K A A E P
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - T P G P P Q N L A V K E V R K D S A F L V W E P P I I D G G A K V K N Y V I D K R E S T R K A Y A N V S S K C S K T S F K V E N L T E G A I Y Y F R V M A E N E F G V G V P V E T V D A V K A A E -

Map SAVs to Structure

The data displayed in the table aims to be as complete as possible and contains information for all available sources including different versions of the same source, for example, different sources of gnomAD. To avoid seeing multiple entries for the same variant, we recommend to sort by Source first.

Pin SAV
Position
Domain position
SAV
Structural Position
RS
Q(SASA)
Disease
Source
MAF
26683 1 T/A 1 rs1447655466 0.1646 None gnomAD-2.1.1 4.02E-06
26683 1 T/A 1 rs1447655466 0.1646 None gnomAD-4.0.0 5.47412E-06
26683 1 T/P 1 None 0.1646 None gnomAD-4.0.0 6.84265E-07
26684 2 P/A 2 rs1705731534 0.0907 None gnomAD-4.0.0 2.05278E-06
26685 3 G/E 3 rs773930240 0.1487 None gnomAD-2.1.1 4.02E-06
26685 3 G/E 3 rs773930240 0.1487 None gnomAD-4.0.0 1.20032E-06
26686 4 P/L 4 rs867306848 0.3464 None gnomAD-2.1.1 4.02E-06
26686 4 P/L 4 rs867306848 0.3464 None gnomAD-3.1.2 6.58E-06
26686 4 P/L 4 rs867306848 0.3464 None gnomAD-4.0.0 6.57549E-06
26687 5 P/Q 5 None 0.1058 None gnomAD-4.0.0 1.36855E-06
26687 5 P/S 5 None 0.1058 None gnomAD-4.0.0 1.20032E-06
26689 7 N/D 7 rs1289700659 0.6300 None gnomAD-2.1.1 3.18E-05
26689 7 N/D 7 rs1289700659 0.6300 None gnomAD-3.1.2 6.57E-06
26689 7 N/D 7 rs1289700659 0.6300 None gnomAD-4.0.0 6.57237E-06
26691 9 A/T 11 None 0.3128 None gnomAD-4.0.0 1.20032E-06
26693 11 K/E 13 None 0.6081 None gnomAD-4.0.0 1.59171E-06
26693 11 K/R 13 rs544750835 0.6081 None gnomAD-2.1.1 4.02E-06
26693 11 K/R 13 rs544750835 0.6081 None gnomAD-3.1.2 6.57E-06
26693 11 K/R 13 rs544750835 0.6081 None 1000 genomes 1.99681E-04
26693 11 K/R 13 rs544750835 0.6081 None gnomAD-4.0.0 6.5678E-06
26695 13 V/L 15 rs772729384 0.2997 None gnomAD-2.1.1 2.82E-05
26695 13 V/L 15 rs772729384 0.2997 None gnomAD-3.1.2 3.94E-05
26695 13 V/L 15 rs772729384 0.2997 None gnomAD-4.0.0 1.9833E-05
26696 14 R/K 16 rs769866606 0.5696 None gnomAD-2.1.1 4.03E-06
26696 14 R/K 16 rs769866606 0.5696 None gnomAD-4.0.0 1.36865E-06
26696 14 R/S 16 None 0.5696 None gnomAD-4.0.0 1.59188E-06
26698 16 D/V 18 rs368085497 0.4493 None gnomAD-2.1.1 8.05E-06
26698 16 D/V 18 rs368085497 0.4493 None gnomAD-4.0.0 1.36866E-05
26699 17 S/P 19 rs1444605407 0.1404 None gnomAD-2.1.1 4.03E-06
26699 17 S/P 19 rs1444605407 0.1404 None gnomAD-4.0.0 3.1838E-06
26701 19 F/L 21 rs575784937 0.2690 None gnomAD-2.1.1 3.22E-05
26701 19 F/L 21 rs575784937 0.2690 None gnomAD-3.1.2 6.57E-06
26701 19 F/L 21 rs575784937 0.2690 None 1000 genomes 1.99681E-04
26701 19 F/L 21 rs575784937 0.2690 None gnomAD-4.0.0 1.40948E-05
26701 19 F/S 21 rs954218807 0.2690 None gnomAD-3.1.2 6.57E-06
26701 19 F/S 21 rs954218807 0.2690 None gnomAD-4.0.0 6.57324E-06
26702 20 L/V 22 rs746800300 0.0977 None gnomAD-2.1.1 4.03E-06
26702 20 L/V 22 rs746800300 0.0977 None gnomAD-4.0.0 3.18377E-06
26703 21 V/L 23 rs1288435749 0.2555 None gnomAD-2.1.1 4.03E-06
26703 21 V/L 23 rs1288435749 0.2555 None gnomAD-4.0.0 4.77584E-06
26704 22 W/L 24 rs780184497 0.0965 None gnomAD-2.1.1 4.03E-06
26704 22 W/L 24 rs780184497 0.0965 None gnomAD-4.0.0 1.59186E-06
26705 23 E/D 25 rs558830502 0.4248 None gnomAD-2.1.1 4.29102E-04
26705 23 E/D 25 rs558830502 0.4248 None gnomAD-3.1.2 1.77529E-04
26705 23 E/D 25 rs558830502 0.4248 None 1000 genomes 5.99042E-04
26705 23 E/D 25 rs558830502 0.4248 None gnomAD-4.0.0 1.3263E-04
26705 23 E/K 25 rs758610676 0.4248 None gnomAD-2.1.1 4.03E-06
26705 23 E/K 25 rs758610676 0.4248 None gnomAD-4.0.0 2.7373E-06
26707 25 P/L 27 None 0.1565 None gnomAD-4.0.0 1.59183E-06
26707 25 P/T 27 None 0.1565 None gnomAD-4.0.0 1.59184E-06
26708 26 I/M 28 rs886043518 0.8744 None gnomAD-2.1.1 4.03E-06
26708 26 I/M 28 rs886043518 0.8744 None gnomAD-4.0.0 3.18369E-06
26709 27 I/T 29 rs757763969 0.3352 None gnomAD-2.1.1 4.03E-06
26709 27 I/T 29 rs757763969 0.3352 None gnomAD-4.0.0 1.5055E-05
26710 28 D/G 30 None 0.3125 None gnomAD-4.0.0 1.5918E-06
26711 29 G/R 31 rs2154165266 0.0945 None gnomAD-4.0.0 3.60097E-06
26714 32 K/N 34 None 0.7759 None gnomAD-4.0.0 1.20033E-06
26715 33 V/F 35 rs1705694653 0.2357 None gnomAD-3.1.2 6.58E-06
26715 33 V/F 35 rs1705694653 0.2357 None gnomAD-4.0.0 2.56306E-06
26716 34 K/E 36 rs902372912 0.4184 None gnomAD-4.0.0 9.57999E-06
26717 35 N/S 37 rs538799672 0.2841 None gnomAD-3.1.2 6.57E-06
26717 35 N/S 37 rs538799672 0.2841 None 1000 genomes 1.99681E-04
26717 35 N/S 37 rs538799672 0.2841 None gnomAD-4.0.0 2.56246E-06
26718 36 Y/C 38 rs1705690461 0.1118 None gnomAD-3.1.2 6.57E-06
26718 36 Y/C 38 rs1705690461 0.1118 None gnomAD-4.0.0 6.57281E-06
26719 37 V/A 39 None 0.1687 None gnomAD-4.0.0 5.47426E-06
26720 38 I/M 40 rs376363284 0.0664 None gnomAD-2.1.1 4.29E-05
26720 38 I/M 40 rs376363284 0.0664 None gnomAD-3.1.2 1.11779E-04
26720 38 I/M 40 rs376363284 0.0664 None gnomAD-4.0.0 9.11071E-05
26720 38 I/T 40 rs879183549 0.0664 None gnomAD-4.0.0 1.59164E-06
26721 39 D/E 41 None 0.1254 None gnomAD-4.0.0 6.84275E-07
26722 40 K/Q 42 None 0.2319 None gnomAD-4.0.0 1.20033E-06
26723 41 R/C 43 rs1412497882 0.1916 None gnomAD-2.1.1 8.05E-06
26723 41 R/C 43 rs1412497882 0.1916 None gnomAD-3.1.2 6.58E-06
26723 41 R/C 43 rs1412497882 0.1916 None gnomAD-4.0.0 1.36352E-05
26723 41 R/H 43 rs371615296 0.1916 None gnomAD-2.1.1 2.14E-05
26723 41 R/H 43 rs371615296 0.1916 None gnomAD-3.1.2 3.94E-05
26723 41 R/H 43 rs371615296 0.1916 None gnomAD-4.0.0 1.6114E-05
26723 41 R/L 43 None 0.1916 None gnomAD-4.0.0 6.84275E-07
26724 42 E/K 44 rs367812761 0.2188 None gnomAD-3.1.2 1.31E-05
26724 42 E/K 44 rs367812761 0.2188 None gnomAD-4.0.0 3.84409E-06
26725 43 S/L 50 rs772603198 0.3437 None gnomAD-2.1.1 4.03E-06
26725 43 S/L 50 rs772603198 0.3437 None gnomAD-4.0.0 1.59166E-06
26725 43 S/P 50 None 0.3437 None gnomAD-4.0.0 2.05284E-06
26726 44 T/A 54 rs1258866379 0.7747 None gnomAD-2.1.1 4.03E-06
26726 44 T/A 54 rs1258866379 0.7747 None gnomAD-4.0.0 1.36856E-06
26726 44 T/I 54 None 0.7747 None gnomAD-4.0.0 1.20032E-06
26726 44 T/P 54 None 0.7747 None gnomAD-4.0.0 6.84279E-07
26727 45 R/S 60 rs769497982 0.5247 None gnomAD-2.1.1 3.57E-05
26727 45 R/S 60 rs769497982 0.5247 None gnomAD-3.1.2 2.63E-05
26727 45 R/S 60 rs769497982 0.5247 None gnomAD-4.0.0 3.58777E-05
26728 46 K/E 63 None 1.0481 None gnomAD-4.0.0 1.5916E-06
26729 47 A/P 64 rs1252013447 0.5554 None gnomAD-3.1.2 6.57E-06
26729 47 A/P 64 rs1252013447 0.5554 None gnomAD-4.0.0 1.85928E-06
26729 47 A/V 64 rs747650124 0.5554 None gnomAD-2.1.1 1.61E-05
26729 47 A/V 64 rs747650124 0.5554 None gnomAD-3.1.2 2.63E-05
26729 47 A/V 64 rs747650124 0.5554 None gnomAD-4.0.0 1.79742E-05
26730 48 Y/F 65 None 0.2188 None gnomAD-4.0.0 1.5916E-06
26730 48 Y/H 65 rs768686591 0.2188 None gnomAD-4.0.0 1.59161E-06
26731 49 A/D 66 rs1410996977 0.3743 None gnomAD-3.1.2 6.58E-06
26731 49 A/D 66 rs1410996977 0.3743 None gnomAD-4.0.0 6.57644E-06
26731 49 A/P 66 rs1451227084 0.3743 None gnomAD-2.1.1 4.02E-06
26731 49 A/T 66 None 0.3743 None gnomAD-4.0.0 1.59163E-06
26733 51 V/E 68 rs746813986 0.2535 None gnomAD-2.1.1 1.61E-05
26733 51 V/E 68 rs746813986 0.2535 None gnomAD-4.0.0 2.05283E-06
26733 51 V/M 68 rs755876442 0.2535 None gnomAD-2.1.1 4.02E-06
26733 51 V/M 68 rs755876442 0.2535 None gnomAD-4.0.0 1.5054E-05
26735 53 S/G 70 None 0.4475 None gnomAD-4.0.0 6.84271E-07
26737 55 C/S 77 rs566764105 0.1055 None gnomAD-2.1.1 2.5E-05
26737 55 C/S 77 rs566764105 0.1055 None gnomAD-3.1.2 1.97E-05
26737 55 C/S 77 rs566764105 0.1055 None 1000 genomes 1.99681E-04
26737 55 C/S 77 rs566764105 0.1055 None gnomAD-4.0.0 1.73524E-05
26741 59 S/G 90 rs750048032 0.2137 None gnomAD-2.1.1 8.04E-06
26741 59 S/G 90 rs750048032 0.2137 None gnomAD-3.1.2 6.57E-06
26741 59 S/G 90 rs750048032 0.2137 None gnomAD-4.0.0 1.54935E-05
26741 59 S/N 90 None 0.2137 None gnomAD-4.0.0 1.20033E-06
26743 61 K/T 92 rs368263400 0.3540 None gnomAD-2.1.1 8.04E-05
26743 61 K/T 92 rs368263400 0.3540 None gnomAD-3.1.2 1.97E-05
26743 61 K/T 92 rs368263400 0.3540 None gnomAD-4.0.0 2.7269E-05
26744 62 V/A 93 None 0.1156 None gnomAD-4.0.0 1.20032E-06
26745 63 E/Q 94 None 0.5065 None gnomAD-4.0.0 6.36649E-06
26746 64 N/H 96 None 0.8863 None gnomAD-4.0.0 3.60097E-06
26746 64 N/K 96 rs1299776307 0.8863 None gnomAD-4.0.0 1.59162E-06
26747 65 L/I 97 rs779100100 0.1243 None gnomAD-2.1.1 4.02E-06
26747 65 L/I 97 rs779100100 0.1243 None gnomAD-4.0.0 3.18327E-06
26748 66 T/A 98 None 0.5591 None gnomAD-4.0.0 1.59159E-06
26748 66 T/R 98 None 0.5591 None gnomAD-4.0.0 1.59161E-06
26749 67 E/K 99 None 0.6071 None gnomAD-4.0.0 1.36854E-06
26751 69 A/D 102 rs912122514 0.1626 None gnomAD-2.1.1 4.02E-06
26751 69 A/D 102 rs912122514 0.1626 None gnomAD-4.0.0 2.05281E-06
26751 69 A/T 102 rs1559345993 0.1626 None gnomAD-4.0.0 1.59158E-06
26751 69 A/V 102 rs912122514 0.1626 None gnomAD-2.1.1 8.04E-06
26751 69 A/V 102 rs912122514 0.1626 None gnomAD-4.0.0 6.84271E-07
26752 70 I/V 103 rs376046847 0.3766 None gnomAD-3.1.2 1.31E-05
26752 70 I/V 103 rs376046847 0.3766 None gnomAD-4.0.0 3.04501E-06
26753 71 Y/S 104 rs1321131877 0.0998 None gnomAD-2.1.1 4.02E-06
26753 71 Y/S 104 rs1321131877 0.0998 None gnomAD-4.0.0 6.36628E-06
26755 73 F/L 106 rs200181804 0.1295 None gnomAD-2.1.1 1.60642E-04
26755 73 F/L 106 rs200181804 0.1295 None gnomAD-3.1.2 2.95784E-04
26755 73 F/L 106 rs200181804 0.1295 None 1000 genomes 3.99361E-04
26755 73 F/L 106 rs200181804 0.1295 None gnomAD-4.0.0 2.9498E-04
26755 73 F/S 106 None 0.1295 None gnomAD-4.0.0 1.59159E-06
26756 74 R/T 107 rs1417881535 0.1985 None gnomAD-2.1.1 4.02E-06
26756 74 R/T 107 rs1417881535 0.1985 None gnomAD-4.0.0 3.18317E-06
26757 75 V/A 108 rs1705638495 0.0788 None gnomAD-4.0.0 1.20032E-06
26757 75 V/D 108 None 0.0788 None gnomAD-4.0.0 2.40064E-06
26757 75 V/L 108 rs1170675568 0.0788 None gnomAD-2.1.1 8.04E-06
26757 75 V/L 108 rs1170675568 0.0788 None gnomAD-4.0.0 2.73706E-06
26758 76 M/I 109 rs1705634558 0.0931 None gnomAD-4.0.0 1.59159E-06
26758 76 M/R 109 None 0.0931 None gnomAD-4.0.0 1.59158E-06
26758 76 M/T 109 None 0.0931 None gnomAD-4.0.0 7.95788E-06
26758 76 M/V 109 None 0.0931 None gnomAD-4.0.0 3.42133E-06
26760 78 E/D 111 rs778292712 0.2986 None gnomAD-2.1.1 1.61E-05
26760 78 E/D 111 rs778292712 0.2986 None gnomAD-4.0.0 5.47418E-06
26761 79 N/T 112 rs1187490566 0.0875 None gnomAD-2.1.1 4.02E-06
26761 79 N/T 112 rs1187490566 0.0875 None gnomAD-4.0.0 1.59161E-06
26762 80 E/K 113 None 0.4115 None gnomAD-4.0.0 1.59164E-06
26764 82 G/A 115 None 0.2019 None gnomAD-4.0.0 6.84271E-07
26764 82 G/R 115 rs727505213 0.2019 None gnomAD-2.1.1 8.04E-06
26764 82 G/R 115 rs727505213 0.2019 None gnomAD-3.1.2 6.57E-05
26764 82 G/R 115 rs727505213 0.2019 None gnomAD-4.0.0 1.61123E-05
26765 83 V/G 117 rs1469008305 0.4179 None gnomAD-2.1.1 4.02E-06
26765 83 V/G 117 rs1469008305 0.4179 None gnomAD-4.0.0 1.5916E-06
26766 84 G/A 118 rs753017013 0.1469 None gnomAD-2.1.1 1.21E-05
26766 84 G/A 118 rs753017013 0.1469 None gnomAD-4.0.0 6.84276E-07
26767 85 V/I 119 rs1559345492 0.3531 None gnomAD-2.1.1 3.19E-05
26767 85 V/I 119 rs1559345492 0.3531 None gnomAD-3.1.2 6.57E-06
26767 85 V/I 119 rs1559345492 0.3531 None gnomAD-4.0.0 1.8593E-06
26767 85 V/L 119 None 0.3531 None gnomAD-4.0.0 6.84277E-07
26769 87 V/A 121 None 0.1831 None gnomAD-4.0.0 1.36854E-06
26769 87 V/L 121 None 0.1831 None gnomAD-4.0.0 6.84273E-07
26769 87 V/M 121 rs745315690 0.1831 None gnomAD-3.1.2 6.57E-06
26769 87 V/M 121 rs745315690 0.1831 None gnomAD-4.0.0 1.2395E-06
26770 88 E/D 122 None 0.3152 None gnomAD-4.0.0 5.47416E-06
26771 89 T/A 123 None 0.1953 None gnomAD-4.0.0 1.20032E-06
26771 89 T/I 123 rs567184856 0.1953 None gnomAD-2.1.1 4.02E-06
26771 89 T/I 123 rs567184856 0.1953 None gnomAD-3.1.2 6.58E-06
26771 89 T/I 123 rs567184856 0.1953 None 1000 genomes 1.99681E-04
26771 89 T/I 123 rs567184856 0.1953 None gnomAD-4.0.0 2.56247E-06
26772 90 V/A 124 None 0.9169 None gnomAD-4.0.0 3.18318E-06
26772 90 V/I 124 rs750148761 0.9169 None gnomAD-2.1.1 8.05E-06
26772 90 V/I 124 rs750148761 0.9169 None gnomAD-4.0.0 6.15847E-06
26773 91 D/E 125 rs1036715959 0.7878 None gnomAD-4.0.0 6.84267E-07
26773 91 D/N 125 None 0.7878 None gnomAD-4.0.0 6.84268E-07
26773 91 D/Y 125 None 0.7878 None gnomAD-4.0.0 6.84268E-07
26774 92 A/V 126 rs1272733739 0.2940 None gnomAD-2.1.1 4.02E-06
26774 92 A/V 126 rs1272733739 0.2940 None gnomAD-4.0.0 6.36643E-06
26775 93 V/M 127 rs370589806 0.2155 None gnomAD-2.1.1 8.05E-06
26775 93 V/M 127 rs370589806 0.2155 None gnomAD-3.1.2 3.95E-05
26775 93 V/M 127 rs370589806 0.2155 None gnomAD-4.0.0 8.67686E-06
26777 95 A/G 130 None 0.0916 None gnomAD-4.0.0 1.20032E-06
26777 95 A/T 130 None 0.0916 None gnomAD-4.0.0 1.36854E-06
26777 95 A/V 130 rs1477186864 0.0916 None gnomAD-2.1.1 3.19E-05
26777 95 A/V 130 rs1477186864 0.0916 None gnomAD-3.1.2 6.58E-06
26777 95 A/V 130 rs1477186864 0.0916 None gnomAD-4.0.0 6.57505E-06
26778 96 A/D 131 rs1463558062 0.3136 None gnomAD-2.1.1 4.02E-06
26778 96 A/D 131 rs1463558062 0.3136 None gnomAD-4.0.0 4.10564E-06
26779 97 E/D 132 rs760599182 0.4753 None gnomAD-2.1.1 4.03E-06
26779 97 E/D 132 rs760599182 0.4753 None gnomAD-4.0.0 6.36647E-06