Select a Data Table to View:



Download domain sequence (FASTA)
Export SAV table to CSV

Select columns to include

Basic Information

SAV Position Domain position
RS Q(SASA) Source Structural position

Pathogenicity / Stability Predictions

AlphaMissense (IC) AlphaMissense (N2AB)
CADD Condel DUET FATHMM M-CAP
mCSM MetaLR MetaSVM MPC MutationAssessor
MutationTaster MutPred MVP PolyPhen-2
PrimateAI PROVEAN REVEL Rhapsody SIFT

Disease Associations

Disease Zygosity Comments

Population Frequencies

Whole Population MAF African (AFR) Latin American (AMR)
Amish (AMS) Ashkenazi Jewish (ASJ) East Asian (EAS)
European/1KGP (EUR) Finnish (FIN) Middle Eastern (MDE)
Non-Finnish European (NFE) South Asian (SAS) Other (OTH)

Other Annotations

Site Annotation Predicted PPI site mCSM-PPI

10 20 30 40 50 60 70 80 90
P P G P P S N P H V T D T T K K S A S L A W G K P H Y D G G L E I T G Y V V E H Q K V G D E A W I K D T T G T A L R I T Q F V V P D L Q T K E K Y N F R I S A I N D A G V G E P A V I P D V E I V E R E
P P G P P S N P H V T D T T K K S A S L A W G K P H Y D G G L E I T G Y V V E H Q K V G D E A W I K D T T G T A L R I T Q F V V P D L Q T K E K Y N F R I S A I N D A G V G E P A V I P D V E I V E R -

Map SAVs to Structure

The data displayed in the table aims to be as complete as possible and contains information for all available sources including different versions of the same source, for example, different sources of gnomAD. To avoid seeing multiple entries for the same variant, we recommend to sort by Source first.

Pin SAV
Position
Domain position
SAV
Structural Position
RS
Q(SASA)
Disease
Source
MAF
23241 2 P/S 2 None 0.1549 None gnomAD-4.0.0 1.69731E-06
23242 3 G/A 3 None 0.2510 None gnomAD-4.0.0 2.1109E-06
23242 3 G/E 3 rs1292885710 0.2510 None gnomAD-2.1.1 3.19E-05
23242 3 G/E 3 rs1292885710 0.2510 None gnomAD-3.1.2 6.58E-06
23242 3 G/E 3 rs1292885710 0.2510 None gnomAD-4.0.0 1.27133E-06
23242 3 G/R 3 rs1312382242 0.2510 None gnomAD-2.1.1 9.49E-06
23242 3 G/R 3 rs1312382242 0.2510 None gnomAD-4.0.0 7.03475E-07
23243 4 P/S 4 rs1221599663 0.4217 None gnomAD-2.1.1 4.71E-06
23243 4 P/S 4 rs1221599663 0.4217 None gnomAD-4.0.0 3.39479E-06
23244 5 P/L 5 rs879056292 0.1771 None gnomAD-2.1.1 3.19E-05
23244 5 P/L 5 rs879056292 0.1771 None gnomAD-3.1.2 6.58E-06
23244 5 P/L 5 rs879056292 0.1771 None gnomAD-4.0.0 1.9125E-06
23247 8 P/L 9 rs115658240 0.3317 None gnomAD-2.1.1 2.99485E-03
23247 8 P/L 9 rs115658240 0.3317 None gnomAD-3.1.2 7.64665E-03
23247 8 P/L 9 rs115658240 0.3317 None 1000 genomes 7.78754E-03
23247 8 P/L 9 rs115658240 0.3317 None gnomAD-4.0.0 1.48008E-03
23248 9 H/P 11 rs1423241119 0.4260 None gnomAD-3.1.2 6.58E-06
23248 9 H/P 11 rs1423241119 0.4260 None gnomAD-4.0.0 1.91718E-06
23248 9 H/Q 11 rs774642251 0.4260 None gnomAD-2.1.1 1.48E-05
23248 9 H/Q 11 rs774642251 0.4260 None gnomAD-4.0.0 2.12342E-06
23248 9 H/R 11 None 0.4260 None gnomAD-4.0.0 7.07834E-07
23248 9 H/Y 11 rs1374089814 0.4260 None gnomAD-2.1.1 1.7E-05
23248 9 H/Y 11 rs1374089814 0.4260 None gnomAD-3.1.2 2.63E-05
23248 9 H/Y 11 rs1374089814 0.4260 None gnomAD-4.0.0 6.83062E-06
23249 10 V/F 12 None 0.3817 None gnomAD-4.0.0 1.72789E-06
23250 11 T/I 13 rs771327436 0.6116 None gnomAD-2.1.1 4.97E-06
23250 11 T/I 13 rs771327436 0.6116 None gnomAD-3.1.2 2.63E-05
23251 12 D/N 14 None 0.7159 None gnomAD-4.0.0 3.47087E-06
23251 12 D/Y 14 None 0.7159 None gnomAD-4.0.0 1.73544E-06
23252 13 T/I 15 None 0.3578 None gnomAD-4.0.0 7.10046E-07
23252 13 T/S 15 rs1710103271 0.3578 None gnomAD-4.0.0 7.10046E-07
23254 15 K/E 17 rs892446768 0.6386 None gnomAD-4.0.0 1.74224E-06
23256 17 S/P 19 rs1710100033 0.3755 None gnomAD-4.0.0 2.84574E-06
23257 18 A/V 20 rs1710097395 0.2349 None gnomAD-4.0.0 1.74597E-06
23258 19 S/F 21 None 0.2960 None gnomAD-4.0.0 7.11426E-07
23258 19 S/P 21 None 0.2960 None gnomAD-4.0.0 3.49355E-06
23258 19 S/Y 21 None 0.2960 None gnomAD-4.0.0 2.8457E-06
23262 23 G/C 25 None 0.1871 None gnomAD-4.0.0 2.84202E-06
23262 23 G/S 25 None 0.1871 None gnomAD-4.0.0 7.10502E-07
23264 25 P/R 27 None 0.2063 None gnomAD-4.0.0 2.12756E-06
23265 26 H/Y 28 rs1265649343 1.1143 None gnomAD-2.1.1 3.19E-05
23265 26 H/Y 28 rs1265649343 1.1143 None gnomAD-3.1.2 6.58E-06
23265 26 H/Y 28 rs1265649343 1.1143 None gnomAD-4.0.0 6.57626E-06
23266 27 Y/S 29 None 0.5804 None gnomAD-4.0.0 1.71684E-06
23267 28 D/H 30 None 0.3648 None gnomAD-4.0.0 1.71681E-06
23268 29 G/V 31 rs1201998813 0.2326 None gnomAD-2.1.1 4.87E-06
23268 29 G/V 31 rs1201998813 0.2326 None gnomAD-4.0.0 1.71243E-06
23269 30 G/E 32 rs750182587 0.4947 None gnomAD-2.1.1 1.95E-05
23269 30 G/E 32 rs750182587 0.4947 None gnomAD-3.1.2 3.29E-05
23269 30 G/E 32 rs750182587 0.4947 None gnomAD-4.0.0 3.05815E-05
23269 30 G/R 32 rs935898140 0.4947 None gnomAD-4.0.0 5.13405E-06
23270 31 L/F 33 rs904477168 0.4468 None gnomAD-3.1.2 6.58E-06
23270 31 L/F 33 rs904477168 0.4468 None gnomAD-4.0.0 6.57523E-06
23270 31 L/I 33 None 0.4468 None gnomAD-4.0.0 2.82019E-06
23271 32 E/G 34 rs779955364 0.8589 None gnomAD-2.1.1 4.82E-06
23271 32 E/G 34 rs779955364 0.8589 None gnomAD-4.0.0 1.40882E-06
23272 33 I/S 35 rs758398301 0.2030 None gnomAD-2.1.1 9.61E-06
23272 33 I/S 35 rs758398301 0.2030 None gnomAD-3.1.2 6.58E-06
23272 33 I/S 35 rs758398301 0.2030 None gnomAD-4.0.0 9.53922E-06
23273 34 T/A 36 rs1233267673 0.4178 None gnomAD-4.0.0 1.70038E-06
23273 34 T/I 36 None 0.4178 None gnomAD-4.0.0 7.03575E-07
23273 34 T/S 36 rs371067787 0.4178 None gnomAD-2.1.1 4.81E-06
23273 34 T/S 36 rs371067787 0.4178 None gnomAD-4.0.0 7.03575E-07
23274 35 G/A 37 rs201043950 0.1189 None gnomAD-2.1.1 4.74E-06
23274 35 G/A 37 rs201043950 0.1189 None gnomAD-4.0.0 7.02499E-07
23274 35 G/D 37 rs201043950 0.1189 None gnomAD-2.1.1 1.20915E-03
23274 35 G/D 37 rs201043950 0.1189 None gnomAD-3.1.2 1.05244E-03
23274 35 G/D 37 rs201043950 0.1189 None 1000 genomes 1.99681E-04
23274 35 G/D 37 rs201043950 0.1189 None gnomAD-4.0.0 1.30678E-03
23274 35 G/S 37 rs786205331 0.1189 None gnomAD-2.1.1 4.74E-06
23274 35 G/S 37 rs786205331 0.1189 None gnomAD-4.0.0 1.69462E-06
23275 36 Y/H 38 rs267599039 0.1574 None gnomAD-3.1.2 1.32E-05
23275 36 Y/H 38 rs267599039 0.1574 None gnomAD-4.0.0 1.31501E-05
23275 36 Y/N 38 rs267599039 0.1574 None gnomAD-2.1.1 4.71E-06
23275 36 Y/N 38 rs267599039 0.1574 None gnomAD-4.0.0 1.68852E-06
23277 38 V/M 40 rs371513781 0.1104 None gnomAD-2.1.1 7.61E-05
23277 38 V/M 40 rs371513781 0.1104 None gnomAD-3.1.2 3.29E-05
23277 38 V/M 40 rs371513781 0.1104 None gnomAD-4.0.0 4.04569E-05
23278 39 E/A 41 None 0.1427 None gnomAD-4.0.0 1.20032E-06
23278 39 E/K 41 None 0.1427 None gnomAD-4.0.0 1.65683E-06
23279 40 H/Q 42 rs752879532 0.2342 None gnomAD-4.0.0 4.15167E-06
23281 42 K/R 44 None 0.2611 None gnomAD-4.0.0 1.62571E-06
23282 43 V/I 50 rs876658079 0.4655 None gnomAD-4.0.0 2.76242E-06
23283 44 G/R 54 None 0.6330 None gnomAD-4.0.0 6.89601E-07
23284 45 D/V 60 rs768131129 0.5695 None gnomAD-2.1.1 4.22E-06
23284 45 D/V 60 rs768131129 0.5695 None gnomAD-4.0.0 4.85197E-06
23285 46 E/G 63 None 1.0878 None gnomAD-4.0.0 7.56972E-06
23285 46 E/K 63 rs376870149 1.0878 None gnomAD-2.1.1 5.93E-05
23285 46 E/K 63 rs376870149 1.0878 None gnomAD-3.1.2 1.97345E-04
23285 46 E/K 63 rs376870149 1.0878 None 1000 genomes 3.99361E-04
23285 46 E/K 63 rs376870149 1.0878 None gnomAD-4.0.0 6.41997E-05
23286 47 A/D 64 rs1465961266 0.5371 None gnomAD-4.0.0 6.87762E-06
23286 47 A/T 64 rs1710048909 0.5371 None gnomAD-4.0.0 4.83852E-06
23286 47 A/V 64 rs1465961266 0.5371 None gnomAD-2.1.1 4.16E-06
23286 47 A/V 64 rs1465961266 0.5371 None gnomAD-4.0.0 6.87762E-07
23287 48 W/S 65 None 0.2791 None gnomAD-4.0.0 1.61185E-06
23288 49 I/K 66 None 0.4371 None gnomAD-4.0.0 6.86314E-06
23288 49 I/M 66 rs368867993 0.4371 None gnomAD-2.1.1 1.45944E-04
23288 49 I/M 66 rs368867993 0.4371 None gnomAD-3.1.2 2.49829E-04
23288 49 I/M 66 rs368867993 0.4371 None 1000 genomes 1.99681E-04
23288 49 I/M 66 rs368867993 0.4371 None gnomAD-4.0.0 1.00045E-04
23288 49 I/R 66 None 0.4371 None gnomAD-4.0.0 6.86314E-07
23288 49 I/T 66 rs373121875 0.4371 None gnomAD-2.1.1 4.12E-06
23290 51 D/H 68 rs776114674 0.2265 None gnomAD-2.1.1 4.1E-06
23290 51 D/H 68 rs776114674 0.2265 None gnomAD-4.0.0 6.85754E-07
23290 51 D/N 68 None 0.2265 None gnomAD-4.0.0 6.85754E-07
23292 53 T/R 70 rs1710041063 0.8984 None gnomAD-4.0.0 1.59613E-06
23293 54 G/R 71 None 0.6489 None gnomAD-4.0.0 1.59617E-06
23294 55 T/I 72 None 1.0524 None gnomAD-4.0.0 1.20032E-06
23295 56 A/D 75 None 0.2790 None gnomAD-4.0.0 1.20032E-06
23295 56 A/T 75 rs746519147 0.2790 None gnomAD-2.1.1 3.25E-05
23295 56 A/T 75 rs746519147 0.2790 None gnomAD-3.1.2 1.32E-05
23295 56 A/T 75 rs746519147 0.2790 None gnomAD-4.0.0 1.05453E-05
23297 58 R/G 83 rs779474257 0.9138 None gnomAD-2.1.1 4.05E-06
23297 58 R/G 83 rs779474257 0.9138 None gnomAD-4.0.0 2.05418E-06
23300 61 Q/L 90 None 0.6700 None gnomAD-4.0.0 1.20032E-06
23301 62 F/L 91 rs372799151 0.2997 None gnomAD-2.1.1 2.26111E-04
23301 62 F/L 91 rs372799151 0.2997 None gnomAD-3.1.2 7.43147E-04
23301 62 F/L 91 rs372799151 0.2997 None 1000 genomes 1.99681E-04
23301 62 F/L 91 rs372799151 0.2997 None gnomAD-4.0.0 1.22144E-04
23302 63 V/I 92 rs190421400 0.4375 None gnomAD-2.1.1 1.50721E-04
23302 63 V/I 92 rs190421400 0.4375 None gnomAD-3.1.2 3.55128E-04
23302 63 V/I 92 rs190421400 0.4375 None 1000 genomes 7.98722E-04
23302 63 V/I 92 rs190421400 0.4375 None gnomAD-4.0.0 7.75029E-05
23303 64 V/D 93 None 0.1549 None gnomAD-4.0.0 4.80129E-06
23303 64 V/L 93 None 0.1549 None gnomAD-4.0.0 1.20032E-06
23305 66 D/N 96 None 0.8757 None gnomAD-4.0.0 2.05367E-06
23306 67 L/P 97 None 0.1948 None gnomAD-4.0.0 1.59296E-06
23311 72 K/R 103 rs1025638052 0.4511 None gnomAD-4.0.0 1.59333E-06
23314 75 F/L 106 None 0.1412 None gnomAD-4.0.0 1.20032E-06
23315 76 R/K 107 rs756974395 0.1758 None gnomAD-2.1.1 6.38E-05
23315 76 R/K 107 rs756974395 0.1758 None gnomAD-3.1.2 1.32E-05
23315 76 R/K 107 rs756974395 0.1758 None gnomAD-4.0.0 3.84767E-06
23315 76 R/S 107 None 0.1758 None gnomAD-4.0.0 1.59308E-06
23317 78 S/R 109 rs1165001201 0.1805 None gnomAD-2.1.1 4.04E-06
23317 78 S/R 109 rs1165001201 0.1805 None gnomAD-4.0.0 3.18633E-06
23318 79 A/V 110 None 0.1056 None gnomAD-4.0.0 1.59314E-06
23319 80 I/M 111 rs540840413 0.2173 None gnomAD-2.1.1 5.73E-05
23319 80 I/M 111 rs540840413 0.2173 None gnomAD-3.1.2 3.29E-05
23319 80 I/M 111 rs540840413 0.2173 None 1000 genomes 3.99361E-04
23319 80 I/M 111 rs540840413 0.2173 None gnomAD-4.0.0 3.03769E-05
23319 80 I/V 111 rs753718401 0.2173 None gnomAD-2.1.1 8.07E-06
23319 80 I/V 111 rs753718401 0.2173 None gnomAD-4.0.0 1.20032E-06
23320 81 N/S 112 rs756468956 0.0936 None gnomAD-2.1.1 4.03E-06
23320 81 N/S 112 rs756468956 0.0936 None gnomAD-3.1.2 1.31E-05
23320 81 N/S 112 rs756468956 0.0936 None gnomAD-4.0.0 2.47986E-06
23321 82 D/H 113 None 0.8575 None gnomAD-4.0.0 3.42293E-06
23321 82 D/N 113 rs571879486 0.8575 None gnomAD-2.1.1 4.04E-06
23321 82 D/N 113 rs571879486 0.8575 None gnomAD-3.1.2 1.32E-05
23321 82 D/N 113 rs571879486 0.8575 None 1000 genomes 1.99681E-04
23321 82 D/N 113 rs571879486 0.8575 None gnomAD-4.0.0 3.71995E-06
23322 83 A/P 114 None 0.4107 None gnomAD-4.0.0 1.59303E-06
23323 84 G/D 115 None 0.2085 None gnomAD-4.0.0 1.20032E-06
23323 84 G/R 115 None 0.2085 None gnomAD-4.0.0 1.20032E-06
23323 84 G/S 115 rs1710012018 0.2085 None gnomAD-4.0.0 1.20032E-06
23324 85 V/A 117 None 0.5761 None gnomAD-4.0.0 1.36898E-06
23324 85 V/F 117 None 0.5761 None gnomAD-4.0.0 3.18564E-06
23324 85 V/I 117 rs1710011007 0.5761 None gnomAD-4.0.0 1.59282E-06
23325 86 G/R 118 rs371871513 0.1912 None gnomAD-2.1.1 3.19E-05
23325 86 G/R 118 rs371871513 0.1912 None gnomAD-3.1.2 1.31E-05
23325 86 G/R 118 rs371871513 0.1912 None gnomAD-4.0.0 3.84632E-06
23325 86 G/V 118 None 0.1912 None gnomAD-4.0.0 1.59281E-06
23326 87 E/K 119 None 0.6331 None gnomAD-4.0.0 1.20032E-06
23327 88 P/S 120 None 0.4446 None gnomAD-4.0.0 3.18491E-06
23328 89 A/V 121 rs1466750954 0.1940 None gnomAD-2.1.1 2.02E-05
23328 89 A/V 121 rs1466750954 0.1940 None gnomAD-3.1.2 6.58E-06
23328 89 A/V 121 rs1466750954 0.1940 None gnomAD-4.0.0 5.70335E-05
23329 90 V/M 122 None 0.4012 None gnomAD-4.0.0 1.20032E-06
23330 91 I/T 123 rs1211020644 0.1871 None gnomAD-2.1.1 4.03E-06
23330 91 I/T 123 rs1211020644 0.1871 None gnomAD-4.0.0 1.59211E-06
23331 92 P/L 124 None 0.5360 None gnomAD-4.0.0 1.5921E-06
23332 93 D/H 125 None 0.5946 None gnomAD-4.0.0 1.36872E-06
23333 94 V/A 126 None 0.3884 None gnomAD-4.0.0 2.40064E-06
23333 94 V/F 126 rs1710003146 0.3884 None gnomAD-4.0.0 1.20032E-06
23336 97 V/I 130 rs781015638 0.9267 None gnomAD-2.1.1 2.01E-05
23336 97 V/I 130 rs781015638 0.9267 None gnomAD-3.1.2 6.58E-06
23336 97 V/I 130 rs781015638 0.9267 None gnomAD-4.0.0 1.05372E-05
23337 98 E/K 131 None 0.8574 None gnomAD-4.0.0 1.59197E-06
23337 98 E/Q 131 rs1709996308 0.8574 None gnomAD-3.1.2 6.58E-06
23337 98 E/Q 131 rs1709996308 0.8574 None gnomAD-4.0.0 2.56339E-06
23338 99 R/Q 132 rs78916558 1.0474 None gnomAD-2.1.1 3.57E-05
23338 99 R/Q 132 rs78916558 1.0474 None gnomAD-3.1.2 1.97E-05
23338 99 R/Q 132 rs78916558 1.0474 None 1000 genomes 3.99361E-04
23338 99 R/Q 132 rs78916558 1.0474 None gnomAD-4.0.0 8.67728E-06
23338 99 R/W 132 rs773695377 1.0474 None gnomAD-2.1.1 1.43E-05
23338 99 R/W 132 rs773695377 1.0474 None gnomAD-3.1.2 1.32E-05
23338 99 R/W 132 rs773695377 1.0474 None gnomAD-4.0.0 9.29804E-06