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Basic Information

SAV Position Domain position
RS Q(SASA) Source Structural position

Pathogenicity / Stability Predictions

AlphaMissense (IC) AlphaMissense (N2AB)
CADD Condel DUET FATHMM M-CAP
mCSM MetaLR MetaSVM MPC MutationAssessor
MutationTaster MutPred MVP PolyPhen-2
PrimateAI PROVEAN REVEL Rhapsody SIFT

Disease Associations

Disease Zygosity Comments

Population Frequencies

Whole Population MAF African (AFR) Latin American (AMR)
Amish (AMS) Ashkenazi Jewish (ASJ) East Asian (EAS)
European/1KGP (EUR) Finnish (FIN) Middle Eastern (MDE)
Non-Finnish European (NFE) South Asian (SAS) Other (OTH)

Other Annotations

Site Annotation Predicted PPI site mCSM-PPI

10 20 30 40 50 60 70 80 90
E P D P P R K L E V T E M T K N S A T L A W L P P L R D G G A K I D G Y I T S Y R E E E Q P A D R W T E Y S V V K D L S L V V T G L K E G K K Y K F R V A A R N A V G V S L P R E A E G V Y E A K E Q L L P P K I L M P E Q I T I K A G K K L R I E A H V Y G K P H P T C K W K K G E D E V V T S S H L A V H K A D S S S I L I I K D V T R K D S G Y Y S L T A E N S S G T D T Q K I K V V V M
E P D P P R K L E V T E M T K N S A T L A W L P P L R D G G A K I D G Y I T S Y R E E E Q P A D R W T E Y S V V K D L S L V V T G L K E G K K Y K F R V A A R N A V G V S L P R E A E G V Y E A K E - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Map SAVs to Structure

The data displayed in the table aims to be as complete as possible and contains information for all available sources including different versions of the same source, for example, different sources of gnomAD. To avoid seeing multiple entries for the same variant, we recommend to sort by Source first.

Pin SAV
Position
Domain position
SAV
Structural Position
RS
Q(SASA)
Disease
Source
MAF
21366 1 E/K 1 rs2049080412 0.5548 None gnomAD-4.0.0 3.21062E-06
21367 2 P/T 2 None 0.1118 None gnomAD-4.0.0 6.86244E-07
21367 2 P/L 2 rs754581725 0.1118 None gnomAD-2.1.1 2.87E-05
21367 2 P/L 2 rs754581725 0.1118 None gnomAD-3.1.2 6.58E-06
21367 2 P/L 2 rs754581725 0.1118 None gnomAD-4.0.0 8.70051E-06
21368 3 D/Y 3 rs1462401348 0.2697 None gnomAD-2.1.1 8.14E-06
21368 3 D/Y 3 rs1462401348 0.2697 None gnomAD-4.0.0 1.37076E-06
21368 3 D/N 3 rs1462401348 0.2697 None gnomAD-4.0.0 6.85379E-07
21368 3 D/H 3 None 0.2697 None gnomAD-4.0.0 6.85379E-07
21369 4 P/R 4 rs778476727 0.2388 None gnomAD-2.1.1 4.06E-06
21369 4 P/R 4 rs778476727 0.2388 None gnomAD-4.0.0 1.59662E-06
21369 4 P/S 4 rs1388682620 0.2388 None gnomAD-2.1.1 3.19E-05
21369 4 P/S 4 rs1388682620 0.2388 None gnomAD-3.1.2 6.58E-06
21369 4 P/S 4 rs1388682620 0.2388 None gnomAD-4.0.0 6.58181E-06
21370 5 P/L 5 rs2049075418 0.1137 None gnomAD-3.1.2 6.58E-06
21370 5 P/L 5 rs2049075418 0.1137 None gnomAD-4.0.0 1.86122E-06
21371 6 R/G 6 rs748901968 0.2482 None gnomAD-3.1.2 1.97E-05
21371 6 R/G 6 rs748901968 0.2482 None gnomAD-4.0.0 1.30258E-05
21371 6 R/S 6 rs2049074403 0.2482 None gnomAD-4.0.0 1.59492E-06
21371 6 R/T 6 None 0.2482 None gnomAD-4.0.0 1.59501E-06
21372 7 K/R 7 rs1186477441 0.3901 None gnomAD-2.1.1 3.19E-05
21372 7 K/R 7 rs1186477441 0.3901 None gnomAD-4.0.0 1.36952E-06
21372 7 K/I 7 None 0.3901 None gnomAD-4.0.0 6.84762E-07
21373 8 L/F 9 rs753245626 0.1265 None gnomAD-2.1.1 4.04E-05
21373 8 L/F 9 rs753245626 0.1265 None gnomAD-4.0.0 2.12238E-05
21373 8 L/S 9 rs1435172600 0.1265 None gnomAD-3.1.2 6.58E-06
21373 8 L/S 9 rs1435172600 0.1265 None gnomAD-4.0.0 3.72061E-06
21375 10 V/M 12 rs371670651 0.1636 None gnomAD-2.1.1 2.82E-05
21375 10 V/M 12 rs371670651 0.1636 None gnomAD-3.1.2 7.23E-05
21375 10 V/M 12 rs371670651 0.1636 None gnomAD-4.0.0 2.1083E-05
21375 10 V/L 12 rs371670651 0.1636 None gnomAD-4.0.0 6.84636E-07
21376 11 T/A 13 rs368683686 0.1891 None gnomAD-2.1.1 4.03E-06
21376 11 T/A 13 rs368683686 0.1891 None gnomAD-3.1.2 6.58E-06
21376 11 T/A 13 rs368683686 0.1891 None gnomAD-4.0.0 8.12071E-06
21376 11 T/S 13 rs1437293840 0.1891 None gnomAD-2.1.1 4.03E-06
21376 11 T/S 13 rs1437293840 0.1891 None gnomAD-4.0.0 4.10739E-06
21380 15 K/R 17 rs2049068326 0.5914 None gnomAD-4.0.0 2.05359E-06
21380 15 K/E 17 None 0.5914 None gnomAD-4.0.0 1.20032E-06
21381 16 N/S 18 rs2154181598 0.5015 None gnomAD-3.1.2 6.58E-06
21381 16 N/S 18 rs2154181598 0.5015 None gnomAD-4.0.0 6.57203E-06
21382 17 S/I 19 rs759348008 0.1745 None gnomAD-2.1.1 4.02E-06
21382 17 S/I 19 rs759348008 0.1745 None gnomAD-4.0.0 1.59289E-06
21383 18 A/T 20 rs727503582 0.0927 None gnomAD-2.1.1 4.02E-06
21383 18 A/T 20 rs727503582 0.0927 None gnomAD-3.1.2 6.58E-06
21383 18 A/T 20 rs727503582 0.0927 None gnomAD-4.0.0 2.72794E-05
21384 19 T/I 21 rs2049065358 0.1951 None gnomAD-3.1.2 6.58E-06
21384 19 T/I 21 rs2049065358 0.1951 None gnomAD-4.0.0 6.5767E-06
21386 21 A/V 23 None 0.0979 None gnomAD-4.0.0 1.36897E-06
21387 22 W/C 24 None 0.1008 None gnomAD-4.0.0 1.59276E-06
21388 23 L/V 25 None 0.1713 None gnomAD-4.0.0 6.84484E-07
21388 23 L/S 25 None 0.1713 None gnomAD-4.0.0 1.59276E-06
21389 24 P/T 26 rs2049063426 0.3621 None gnomAD-3.1.2 6.58E-06
21389 24 P/T 26 rs2049063426 0.3621 None gnomAD-4.0.0 6.57756E-06
21390 25 P/A 27 None 0.1347 None gnomAD-4.0.0 1.20032E-06
21390 25 P/L 27 rs763262121 0.1347 None gnomAD-2.1.1 1.07E-05
21390 25 P/L 27 rs763262121 0.1347 None gnomAD-3.1.2 1.32E-05
21390 25 P/L 27 rs763262121 0.1347 None gnomAD-4.0.0 1.28225E-05
21391 26 L/R 28 None 0.7804 None gnomAD-4.0.0 1.59276E-06
21392 27 R/P 29 rs777176324 0.6358 None gnomAD-3.1.2 6.58E-06
21392 27 R/P 29 rs777176324 0.6358 None gnomAD-4.0.0 6.57626E-06
21392 27 R/L 29 rs777176324 0.6358 None gnomAD-2.1.1 4.02E-06
21392 27 R/L 29 rs777176324 0.6358 None gnomAD-4.0.0 1.36899E-06
21392 27 R/H 29 None 0.6358 None gnomAD-2.1.1 6.43E-05
21392 27 R/H 29 None 0.6358 None gnomAD-3.1.2 6.58E-05
21392 27 R/H 29 None 0.6358 None gnomAD-4.0.0 5.1457E-05
21392 27 R/G 29 None 0.6358 None gnomAD-4.0.0 6.84489E-07
21392 27 R/C 29 rs72646859 0.6358 None gnomAD-2.1.1 6.1088E-04
21392 27 R/C 29 rs72646859 0.6358 None gnomAD-3.1.2 5.39296E-04
21392 27 R/C 29 rs72646859 0.6358 None gnomAD-4.0.0 8.00317E-04
21393 28 D/H 30 None 0.3576 None gnomAD-4.0.0 1.59277E-06
21394 29 G/R 31 None 0.3282 None gnomAD-4.0.0 1.59279E-06
21395 30 G/A 32 rs769161359 0.6331 None gnomAD-2.1.1 4.02E-06
21395 30 G/A 32 rs769161359 0.6331 None gnomAD-3.1.2 6.58E-06
21395 30 G/A 32 rs769161359 0.6331 None gnomAD-4.0.0 1.23992E-06
21395 30 G/D 32 None 0.6331 None gnomAD-4.0.0 1.36897E-06
21395 30 G/S 32 rs199863338 0.6331 None gnomAD-4.0.0 6.84486E-07
21395 30 G/V 32 rs769161359 0.6331 None gnomAD-4.0.0 4.7914E-06
21396 31 A/G 33 None 0.2419 None gnomAD-2.1.1 4.02E-06
21396 31 A/G 33 None 0.2419 None gnomAD-4.0.0 2.05348E-06
21396 31 A/V 33 rs747305122 0.2419 None gnomAD-2.1.1 4.02E-06
21396 31 A/V 33 rs747305122 0.2419 None gnomAD-4.0.0 6.84492E-07
21398 33 I/S 35 rs727504754 0.2112 None gnomAD-2.1.1 3.22E-05
21398 33 I/S 35 rs727504754 0.2112 None gnomAD-4.0.0 1.75201E-05
21399 34 D/N 36 rs749018114 0.3910 None gnomAD-2.1.1 2.41E-05
21399 34 D/N 36 rs749018114 0.3910 None gnomAD-3.1.2 3.29E-05
21399 34 D/N 36 rs749018114 0.3910 None gnomAD-4.0.0 2.66592E-05
21400 35 G/S 37 rs755708220 0.1054 None gnomAD-2.1.1 4.02E-06
21401 36 Y/C 38 None 0.1184 None gnomAD-4.0.0 1.59274E-06
21401 36 Y/H 38 None 0.1184 None gnomAD-4.0.0 1.59272E-06
21402 37 I/V 39 rs1157697777 0.2494 None gnomAD-2.1.1 4.02E-06
21402 37 I/V 39 rs1157697777 0.2494 None gnomAD-4.0.0 4.77809E-06
21403 38 T/I 40 rs2042996 0.1306 None 1000 genomes 5.07588E-01
21403 38 T/I 40 rs2042996 0.1306 None gnomAD-2.1.1 3.50373E-01
21403 38 T/I 40 rs2042996 0.1306 None gnomAD-3.1.2 3.56988E-01
21403 38 T/I 40 rs2042996 0.1306 None gnomAD-4.0.0 2.75244E-01
21404 39 S/T 41 None 0.0980 None gnomAD-4.0.0 1.59264E-06
21404 39 S/R 41 rs1159259078 0.0980 None gnomAD-2.1.1 4.02E-06
21404 39 S/R 41 rs1159259078 0.0980 None gnomAD-4.0.0 1.59262E-06
21407 42 E/G 44 rs1413732448 0.2366 None gnomAD-3.1.2 6.58E-06
21407 42 E/G 44 rs1413732448 0.2366 None gnomAD-4.0.0 6.09034E-06
21408 43 E/K 50 None 0.3722 None gnomAD-4.0.0 1.59261E-06
21409 44 E/K 51 None 0.7461 None gnomAD-4.0.0 1.20033E-06
21412 47 A/S 62 None 0.5101 None gnomAD-4.0.0 1.20032E-06
21413 48 D/G 63 rs375659466 0.7149 None 1000 genomes 1.99681E-04
21413 48 D/G 63 rs375659466 0.7149 None gnomAD-2.1.1 1.07E-05
21413 48 D/G 63 rs375659466 0.7149 None gnomAD-3.1.2 2.63E-05
21413 48 D/G 63 rs375659466 0.7149 None gnomAD-4.0.0 4.4011E-05
21414 49 R/C 64 rs373478378 0.6587 None gnomAD-2.1.1 4.02E-06
21414 49 R/C 64 rs373478378 0.6587 None gnomAD-3.1.2 6.58E-06
21414 49 R/C 64 rs373478378 0.6587 None gnomAD-4.0.0 1.85986E-06
21414 49 R/H 64 rs727504690 0.6587 None gnomAD-2.1.1 2.41E-05
21414 49 R/H 64 rs727504690 0.6587 None gnomAD-3.1.2 2.63E-05
21414 49 R/H 64 rs727504690 0.6587 None gnomAD-4.0.0 1.11591E-05
21415 50 W/C 65 rs369299712 0.2298 None gnomAD-2.1.1 8.04E-06
21415 50 W/C 65 rs369299712 0.2298 None gnomAD-3.1.2 6.58E-06
21415 50 W/C 65 rs369299712 0.2298 None gnomAD-4.0.0 1.30187E-05
21416 51 T/I 66 None 0.3403 None gnomAD-4.0.0 1.59261E-06
21417 52 E/D 67 rs879230654 0.6822 None gnomAD-4.0.0 1.36892E-06
21417 52 E/Q 67 None 0.6822 None gnomAD-4.0.0 6.84448E-07
21418 53 Y/S 68 rs573165930 0.2647 None 1000 genomes 5.99042E-04
21418 53 Y/S 68 rs573165930 0.2647 None gnomAD-2.1.1 5.36E-05
21418 53 Y/S 68 rs573165930 0.2647 None gnomAD-3.1.2 3.95E-05
21418 53 Y/S 68 rs573165930 0.2647 None gnomAD-4.0.0 1.54971E-05
21420 55 V/L 75 None 0.3762 None gnomAD-4.0.0 1.59254E-06
21420 55 V/A 75 rs765213969 0.3762 None gnomAD-2.1.1 4.02E-06
21420 55 V/A 75 rs765213969 0.3762 None gnomAD-3.1.2 6.58E-06
21420 55 V/A 75 rs765213969 0.3762 None gnomAD-4.0.0 6.58007E-06
21422 57 K/N 83 rs758963173 0.7750 None gnomAD-4.0.0 4.10669E-06
21422 57 K/R 83 None 0.7750 None gnomAD-4.0.0 1.20032E-06
21423 58 D/Y 88 rs761820626 0.6839 None gnomAD-2.1.1 4.02E-06
21423 58 D/Y 88 rs761820626 0.6839 None gnomAD-3.1.2 6.58E-06
21423 58 D/Y 88 rs761820626 0.6839 None gnomAD-4.0.0 1.23989E-06
21424 59 L/V 89 None 0.2407 None gnomAD-4.0.0 1.36889E-06
21424 59 L/Q 89 None 0.2407 None gnomAD-4.0.0 1.20032E-06
21426 61 L/F 91 rs1235011285 0.1755 None gnomAD-2.1.1 4.02E-06
21426 61 L/F 91 rs1235011285 0.1755 None gnomAD-3.1.2 6.58E-06
21426 61 L/F 91 rs1235011285 0.1755 None gnomAD-4.0.0 5.12877E-06
21428 63 V/F 93 None 0.0927 None gnomAD-4.0.0 1.59263E-06
21428 63 V/A 93 rs1576014979 0.0927 None gnomAD-3.1.2 6.58E-06
21428 63 V/A 93 rs1576014979 0.0927 None gnomAD-4.0.0 2.56421E-06
21429 64 T/I 94 rs1276697618 0.4461 None gnomAD-2.1.1 3.19E-05
21429 64 T/I 94 rs1276697618 0.4461 None gnomAD-3.1.2 6.58E-06
21429 64 T/I 94 rs1276697618 0.4461 None gnomAD-4.0.0 2.56412E-06
21430 65 G/A 96 rs1186264863 0.5115 None gnomAD-3.1.2 6.58E-06
21430 65 G/A 96 rs1186264863 0.5115 None gnomAD-4.0.0 6.57601E-06
21430 65 G/D 96 None 0.5115 None gnomAD-4.0.0 3.18524E-06
21430 65 G/S 96 rs2049038476 0.5115 None gnomAD-4.0.0 1.59258E-06
21432 67 K/R 98 rs1297397587 0.5221 None gnomAD-2.1.1 4.02E-06
21432 67 K/R 98 rs1297397587 0.5221 None gnomAD-3.1.2 1.97E-05
21432 67 K/R 98 rs1297397587 0.5221 None gnomAD-4.0.0 7.43908E-06
21434 69 G/R 100 rs1397887723 0.3577 None gnomAD-2.1.1 4.02E-06
21434 69 G/R 100 rs1397887723 0.3577 None gnomAD-3.1.2 6.58E-06
21434 69 G/R 100 rs1397887723 0.3577 None gnomAD-4.0.0 2.56431E-06
21434 69 G/E 100 None 0.3577 None gnomAD-4.0.0 1.36892E-06
21435 70 K/Q 102 None 0.3269 None gnomAD-4.0.0 1.59261E-06
21438 73 K/E 105 None 0.2202 None gnomAD-4.0.0 1.59257E-06
21442 77 A/V 109 rs769108408 0.1020 None gnomAD-2.1.1 8.06E-06
21442 77 A/V 109 rs769108408 0.1020 None gnomAD-3.1.2 2.63E-05
21442 77 A/V 109 rs769108408 0.1020 None gnomAD-4.0.0 1.92188E-05
21442 77 A/T 109 rs886042279 0.1020 None gnomAD-2.1.1 4.03E-06
21442 77 A/T 109 rs886042279 0.1020 None gnomAD-4.0.0 3.18522E-06
21444 79 R/I 111 rs775693601 0.2599 None gnomAD-2.1.1 4.03E-06
21444 79 R/I 111 rs775693601 0.2599 None gnomAD-4.0.0 1.59253E-06
21444 79 R/K 111 rs775693601 0.2599 None gnomAD-2.1.1 4.03E-06
21444 79 R/K 111 rs775693601 0.2599 None gnomAD-4.0.0 1.59253E-06
21446 81 A/V 113 None 0.6656 None gnomAD-4.0.0 1.59252E-06
21447 82 V/A 114 rs2049030119 0.6735 None gnomAD-3.1.2 6.58E-06
21447 82 V/A 114 rs2049030119 0.6735 None gnomAD-4.0.0 3.09964E-06
21448 83 G/A 115 None 0.1847 None gnomAD-4.0.0 1.20032E-06
21449 84 V/A 117 rs748888420 0.3678 None gnomAD-2.1.1 1.07E-05
21449 84 V/A 117 rs748888420 0.3678 None gnomAD-3.1.2 1.98E-05
21449 84 V/A 117 rs748888420 0.3678 None gnomAD-4.0.0 6.4118E-06
21449 84 V/I 117 rs2049029716 0.3678 None gnomAD-3.1.2 6.58E-06
21449 84 V/I 117 rs2049029716 0.3678 None gnomAD-4.0.0 2.03005E-06
21450 85 S/T 118 None 0.0909 None gnomAD-4.0.0 1.20032E-06
21450 85 S/R 118 None 0.0909 None gnomAD-4.0.0 3.60097E-06
21451 86 L/F 119 rs1576014111 0.9387 None gnomAD-4.0.0 6.84458E-07
21453 88 R/G 121 rs1014690727 0.3410 None gnomAD-2.1.1 4.03E-06
21453 88 R/G 121 rs1014690727 0.3410 None gnomAD-3.1.2 1.97E-05
21453 88 R/G 121 rs1014690727 0.3410 None gnomAD-4.0.0 8.97411E-06
21453 88 R/K 121 None 0.3410 None gnomAD-4.0.0 1.36894E-06
21453 88 R/T 121 rs765575975 0.3410 None gnomAD-4.0.0 1.36894E-06
21454 89 E/A 122 rs373183196 0.3821 None gnomAD-2.1.1 4.03E-06
21456 91 E/K 124 rs1432709459 1.0735 None gnomAD-4.0.0 1.20032E-06
21457 92 G/R 125 None 0.3739 None gnomAD-4.0.0 1.59274E-06
21457 92 G/E 125 rs2049025749 0.3739 None gnomAD-4.0.0 1.20032E-06
21460 95 E/K 129 None 0.3206 None gnomAD-4.0.0 1.59286E-06
21461 96 A/V 130 None 0.0788 None gnomAD-4.0.0 1.59305E-06
21462 97 K/R 131 rs1275082313 0.3213 None gnomAD-2.1.1 4.04E-06
21462 97 K/R 131 rs1275082313 0.3213 None gnomAD-4.0.0 1.36914E-06
21462 97 K/T 131 None 0.3213 None gnomAD-4.0.0 6.8457E-07
21463 98 E/K 132 rs1214364121 0.8809 None gnomAD-2.1.1 4.04E-06