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Basic Information

SAV Position Domain position
RS Q(SASA) Source Structural position

Pathogenicity / Stability Predictions

AlphaMissense (IC) AlphaMissense (N2AB)
CADD Condel DUET FATHMM M-CAP
mCSM MetaLR MetaSVM MPC MutationAssessor
MutationTaster MutPred MVP PolyPhen-2
PrimateAI PROVEAN REVEL Rhapsody SIFT

Disease Associations

Disease Zygosity Comments

Population Frequencies

Whole Population MAF African (AFR) Latin American (AMR)
Amish (AMS) Ashkenazi Jewish (ASJ) East Asian (EAS)
European/1KGP (EUR) Finnish (FIN) Middle Eastern (MDE)
Non-Finnish European (NFE) South Asian (SAS) Other (OTH)

Other Annotations

Site Annotation Predicted PPI site mCSM-PPI

10 20 30 40 50 60 70 80 90
S P N S P E G P L E Y D D I Q V R S V R V S W R P P A D D G G A D I L G Y I L E R R E V P K A A W Y T I D S R V R G T S L V V K G L K E N V E Y H F R V S A E N Q F G I S K P L K S E E P V T P K T P L N P P E P P S N P P E V L D V T K S S V S L S W S R P K D D G G S R V T G Y Y I E R K E T S T D K W V R H N K T Q I T T T M Y T V T G L V P D A E Y Q F R I I A Q N D V G L S E T S P A S E P V V C K D P
S P N S P E G P L E Y D D I Q V R S V R V S W R P P A D D G G A D I L G Y I L E R R E V P K A A W Y T I D S R V R G T S L V V K G L K E N V E Y H F R V S A E N Q F G I S K P L K S E E P V T P K T - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Map SAVs to Structure

The data displayed in the table aims to be as complete as possible and contains information for all available sources including different versions of the same source, for example, different sources of gnomAD. To avoid seeing multiple entries for the same variant, we recommend to sort by Source first.

Pin SAV
Position
Domain position
SAV
Structural Position
RS
Q(SASA)
Disease
Source
MAF
32795 1 S/R 1 rs373396567 0.4558 None gnomAD-2.1.1 6.8E-05
32795 1 S/R 1 rs373396567 0.4558 None gnomAD-3.1.2 1.64569E-04
32795 1 S/R 1 rs373396567 0.4558 None gnomAD-4.0.0 3.0991E-05
32796 2 P/A 2 rs1693423139 0.1235 None gnomAD-4.0.0 1.59158E-06
32796 2 P/L 2 None 0.1235 None gnomAD-4.0.0 8.89541E-06
32796 2 P/S 2 None 0.1235 None gnomAD-4.0.0 1.59158E-06
32797 3 N/K 3 None 0.5224 None gnomAD-4.0.0 6.84252E-07
32797 3 N/S 3 rs149001703 0.5224 None gnomAD-2.1.1 4.38233E-03
32797 3 N/S 3 rs149001703 0.5224 None gnomAD-3.1.2 4.97705E-03
32797 3 N/S 3 rs149001703 0.5224 None 1000 genomes 3.99361E-03
32797 3 N/S 3 rs149001703 0.5224 None gnomAD-4.0.0 5.94974E-03
32799 5 P/L 5 None 0.1112 None gnomAD-4.0.0 1.59151E-06
32800 6 E/K 6 None 0.3478 None gnomAD-4.0.0 1.08029E-05
32801 7 G/A 7 None 0.3831 None gnomAD-4.0.0 6.84241E-07
32801 7 G/E 7 None 0.3831 None gnomAD-4.0.0 1.36848E-06
32801 7 G/R 7 rs1351373936 0.3831 None gnomAD-2.1.1 4.03E-06
32801 7 G/R 7 rs1351373936 0.3831 None gnomAD-4.0.0 3.18283E-06
32802 8 P/T 8 rs1165279106 0.6609 None gnomAD-2.1.1 4.03E-06
32802 8 P/T 8 rs1165279106 0.6609 None gnomAD-3.1.2 6.57E-06
32802 8 P/T 8 rs1165279106 0.6609 None gnomAD-4.0.0 2.56264E-06
32803 9 L/P 9 None 0.1717 None gnomAD-4.0.0 1.59136E-06
32808 14 I/S 15 None 0.2547 None gnomAD-4.0.0 1.20032E-06
32808 14 I/T 15 rs1388284089 0.2547 None gnomAD-2.1.1 4.03E-06
32809 15 Q/H 16 rs1271415335 0.3666 None gnomAD-3.1.2 6.57E-06
32809 15 Q/H 16 rs1271415335 0.3666 None gnomAD-4.0.0 2.5622E-06
32809 15 Q/P 16 rs1060500398 0.3666 None gnomAD-2.1.1 3.19E-05
32809 15 Q/P 16 rs1060500398 0.3666 None gnomAD-3.1.2 6.57E-06
32809 15 Q/P 16 rs1060500398 0.3666 None gnomAD-4.0.0 3.09854E-06
32811 17 R/C 18 rs371807358 0.6745 None gnomAD-2.1.1 8.58E-05
32811 17 R/C 18 rs371807358 0.6745 None gnomAD-3.1.2 7.89E-05
32811 17 R/C 18 rs371807358 0.6745 None gnomAD-4.0.0 9.11005E-05
32811 17 R/H 18 rs751450347 0.6745 None gnomAD-2.1.1 2.82E-05
32811 17 R/H 18 rs751450347 0.6745 None gnomAD-3.1.2 1.97E-05
32811 17 R/H 18 rs751450347 0.6745 None gnomAD-4.0.0 1.36341E-05
32811 17 R/L 18 None 0.6745 None gnomAD-4.0.0 1.36847E-06
32812 18 S/P 19 None 0.1419 None gnomAD-4.0.0 8.40225E-06
32813 19 V/L 20 None 0.0937 None gnomAD-4.0.0 6.84202E-07
32813 19 V/M 20 rs1693400485 0.0937 None gnomAD-4.0.0 2.05261E-06
32814 20 R/K 21 rs1487649539 0.3440 None gnomAD-2.1.1 4.03E-06
32814 20 R/K 21 rs1487649539 0.3440 None gnomAD-4.0.0 6.84205E-07
32814 20 R/T 21 rs1487649539 0.3440 None gnomAD-2.1.1 4.03E-06
32814 20 R/T 21 rs1487649539 0.3440 None gnomAD-3.1.2 6.57E-06
32814 20 R/T 21 rs1487649539 0.3440 None gnomAD-4.0.0 1.85912E-06
32816 22 S/N 23 rs773294476 0.2076 None gnomAD-2.1.1 8.05E-06
32816 22 S/N 23 rs773294476 0.2076 None gnomAD-4.0.0 3.18246E-06
32818 24 R/K 25 rs794729551 0.3535 None gnomAD-2.1.1 3.19E-05
32818 24 R/K 25 rs794729551 0.3535 None gnomAD-3.1.2 1.97E-05
32818 24 R/K 25 rs794729551 0.3535 None gnomAD-4.0.0 5.12407E-06
32820 26 P/S 27 rs769919302 0.1673 None gnomAD-2.1.1 1.21E-05
32820 26 P/S 27 rs769919302 0.1673 None gnomAD-3.1.2 1.31E-05
32820 26 P/S 27 rs769919302 0.1673 None gnomAD-4.0.0 8.9673E-06
32822 28 D/A 29 rs191054704 0.5158 None gnomAD-3.1.2 6.57E-06
32822 28 D/A 29 rs191054704 0.5158 None 1000 genomes 1.99681E-04
32822 28 D/A 29 rs191054704 0.5158 None gnomAD-4.0.0 6.56711E-06
32822 28 D/G 29 rs191054704 0.5158 None gnomAD-2.1.1 5.72E-05
32822 28 D/G 29 rs191054704 0.5158 None gnomAD-3.1.2 1.97E-05
32822 28 D/G 29 rs191054704 0.5158 None gnomAD-4.0.0 2.60262E-05
32822 28 D/N 29 rs921446344 0.5158 None gnomAD-2.1.1 7.14E-06
32822 28 D/N 29 rs921446344 0.5158 None gnomAD-3.1.2 1.97E-05
32822 28 D/N 29 rs921446344 0.5158 None gnomAD-4.0.0 5.57708E-06
32823 29 D/N 30 rs1365292715 0.3186 None gnomAD-2.1.1 4.02E-06
32823 29 D/N 30 rs1365292715 0.3186 None gnomAD-4.0.0 3.18222E-06
32823 29 D/V 30 None 0.3186 None gnomAD-4.0.0 1.20032E-06
32824 30 G/D 31 None 0.2562 None gnomAD-4.0.0 6.84179E-07
32825 31 G/S 32 rs747479441 0.5689 None gnomAD-2.1.1 8.04E-06
32825 31 G/S 32 rs747479441 0.5689 None gnomAD-4.0.0 4.77339E-06
32826 32 A/T 33 None 0.1934 None gnomAD-4.0.0 1.09469E-05
32827 33 D/G 34 rs780460404 0.9751 None gnomAD-2.1.1 1.21E-05
32827 33 D/G 34 rs780460404 0.9751 None gnomAD-4.0.0 4.77327E-06
32828 34 I/V 35 rs199689554 0.2128 None gnomAD-2.1.1 4.28E-05
32828 34 I/V 35 rs199689554 0.2128 None gnomAD-3.1.2 1.31E-05
32828 34 I/V 35 rs199689554 0.2128 None gnomAD-4.0.0 1.67304E-05
32830 36 G/D 37 rs748981337 0.1419 None gnomAD-2.1.1 1.61E-05
32830 36 G/D 37 rs748981337 0.1419 None gnomAD-4.0.0 7.95558E-06
32833 39 L/F 40 rs1368567004 0.0969 None gnomAD-2.1.1 4.02E-06
32833 39 L/F 40 rs1368567004 0.0969 None gnomAD-4.0.0 1.59111E-06
32833 39 L/P 40 None 0.0969 None gnomAD-4.0.0 1.59113E-06
32834 40 E/A 41 rs2154140011 0.1514 None gnomAD-3.1.2 1.97E-05
32834 40 E/A 41 rs2154140011 0.1514 None gnomAD-4.0.0 6.40431E-06
32834 40 E/K 41 rs199761901 0.1514 None gnomAD-2.1.1 1.57071E-04
32834 40 E/K 41 rs199761901 0.1514 None gnomAD-3.1.2 3.48441E-04
32834 40 E/K 41 rs199761901 0.1514 None 1000 genomes 1.99681E-04
32834 40 E/K 41 rs199761901 0.1514 None gnomAD-4.0.0 9.41866E-05
32834 40 E/Q 41 rs199761901 0.1514 None gnomAD-2.1.1 4.02E-06
32834 40 E/Q 41 rs199761901 0.1514 None gnomAD-4.0.0 6.84185E-07
32836 42 R/Q 43 rs368312810 0.2014 None gnomAD-2.1.1 8.04E-06
32836 42 R/Q 43 rs368312810 0.2014 None gnomAD-3.1.2 1.31E-05
32836 42 R/Q 43 rs368312810 0.2014 None gnomAD-4.0.0 1.11546E-05
32837 43 E/Q 44 None 0.2145 None gnomAD-4.0.0 1.59111E-06
32838 44 V/E 50 None 0.3420 None gnomAD-4.0.0 6.84182E-07
32838 44 V/L 50 rs200318160 0.3420 None gnomAD-2.1.1 4.02E-06
32838 44 V/L 50 rs200318160 0.3420 None gnomAD-3.1.2 6.58E-06
32838 44 V/L 50 rs200318160 0.3420 None gnomAD-4.0.0 2.05255E-06
32838 44 V/M 50 None 0.3420 None gnomAD-2.1.1 7.14E-06
32838 44 V/M 50 None 0.3420 None gnomAD-3.1.2 6.58E-06
32838 44 V/M 50 None 0.3420 None gnomAD-4.0.0 8.67578E-06
32839 45 P/R 54 None 0.6249 None gnomAD-4.0.0 1.20032E-06
32839 45 P/T 54 rs949917519 0.6249 None gnomAD-4.0.0 2.25781E-05
32841 47 A/T 63 None 0.7222 None gnomAD-4.0.0 6.84185E-07
32842 48 A/S 64 rs199647622 0.3363 None gnomAD-2.1.1 1.61E-05
32842 48 A/S 64 rs199647622 0.3363 None gnomAD-3.1.2 1.97E-05
32842 48 A/S 64 rs199647622 0.3363 None gnomAD-4.0.0 9.29568E-06
32842 48 A/T 64 rs199647622 0.3363 None gnomAD-2.1.1 6.07E-05
32842 48 A/T 64 rs199647622 0.3363 None gnomAD-3.1.2 1.32E-05
32842 48 A/T 64 rs199647622 0.3363 None gnomAD-4.0.0 2.54082E-05
32843 49 W/C 65 None 0.2213 None gnomAD-4.0.0 1.59116E-06
32843 49 W/G 65 rs765326523 0.2213 None gnomAD-2.1.1 4.02E-06
32843 49 W/G 65 rs765326523 0.2213 None gnomAD-4.0.0 1.59114E-06
32844 50 Y/C 66 None 0.5731 None gnomAD-4.0.0 3.18231E-06
32844 50 Y/N 66 None 0.5731 None gnomAD-4.0.0 1.20032E-06
32845 51 T/I 67 rs1230480423 0.4957 None gnomAD-4.0.0 2.73676E-06
32846 52 I/T 68 rs762000616 0.2458 None gnomAD-2.1.1 1.07E-05
32846 52 I/T 68 rs762000616 0.2458 None gnomAD-3.1.2 1.32E-05
32846 52 I/T 68 rs762000616 0.2458 None gnomAD-4.0.0 5.1246E-06
32847 53 D/N 69 None 0.2826 None gnomAD-4.0.0 1.59117E-06
32847 53 D/Y 69 rs776728106 0.2826 None gnomAD-2.1.1 1.21E-05
32847 53 D/Y 69 rs776728106 0.2826 None gnomAD-4.0.0 6.36468E-06
32851 57 R/Q 83 rs775915301 0.9103 None gnomAD-2.1.1 5.71E-05
32851 57 R/Q 83 rs775915301 0.9103 None gnomAD-3.1.2 1.97E-05
32851 57 R/Q 83 rs775915301 0.9103 None gnomAD-4.0.0 2.29295E-05
32852 58 G/S 88 None 0.3206 None gnomAD-4.0.0 1.59117E-06
32852 58 G/V 88 rs1693340480 0.3206 None gnomAD-4.0.0 1.59121E-06
32853 59 T/I 89 rs746181929 0.2459 None gnomAD-2.1.1 4.02E-06
32853 59 T/I 89 rs746181929 0.2459 None gnomAD-4.0.0 4.10519E-06
32854 60 S/F 90 rs958621500 0.3189 None gnomAD-2.1.1 1.21E-05
32854 60 S/F 90 rs958621500 0.3189 None gnomAD-3.1.2 3.29E-05
32854 60 S/F 90 rs958621500 0.3189 None gnomAD-4.0.0 6.19697E-06
32854 60 S/T 90 None 0.3189 None gnomAD-4.0.0 2.05259E-06
32854 60 S/Y 90 None 0.3189 None gnomAD-4.0.0 6.84198E-07
32855 61 L/P 91 rs772942895 0.2687 None gnomAD-2.1.1 4.02E-06
32855 61 L/P 91 rs772942895 0.2687 None gnomAD-4.0.0 6.15782E-06
32856 62 V/L 92 rs1693334476 0.3010 None gnomAD-3.1.2 6.57E-06
32856 62 V/L 92 rs1693334476 0.3010 None gnomAD-4.0.0 6.57479E-06
32857 63 V/I 93 rs1472412628 0.1166 None gnomAD-2.1.1 4.02E-06
32857 63 V/I 93 rs1472412628 0.1166 None gnomAD-4.0.0 1.59115E-06
32858 64 K/T 94 rs1322355821 0.6800 None gnomAD-4.0.0 3.18228E-06
32859 65 G/A 96 rs370747109 0.4857 None gnomAD-2.1.1 4.02E-06
32859 65 G/A 96 rs370747109 0.4857 None gnomAD-4.0.0 2.73674E-06
32859 65 G/D 96 rs370747109 0.4857 None gnomAD-2.1.1 4.02E-06
32859 65 G/D 96 rs370747109 0.4857 None gnomAD-3.1.2 1.32E-05
32859 65 G/D 96 rs370747109 0.4857 None gnomAD-4.0.0 1.85914E-06
32859 65 G/S 96 rs747772240 0.4857 None gnomAD-2.1.1 4.02E-06
32859 65 G/S 96 rs747772240 0.4857 None gnomAD-4.0.0 1.59114E-06
32859 65 G/V 96 None 0.4857 None gnomAD-4.0.0 6.84185E-07
32862 68 E/G 99 rs754522958 0.4976 None gnomAD-2.1.1 4.02E-06
32862 68 E/G 99 rs754522958 0.4976 None gnomAD-4.0.0 1.59116E-06
32862 68 E/K 99 rs1693326100 0.4976 None gnomAD-4.0.0 3.42093E-06
32862 68 E/V 99 rs754522958 0.4976 None gnomAD-2.1.1 1.2E-05
32862 68 E/V 99 rs754522958 0.4976 None gnomAD-3.1.2 6.57E-06
32862 68 E/V 99 rs754522958 0.4976 None gnomAD-4.0.0 5.12399E-06
32863 69 N/Y 100 rs746957606 0.7321 None gnomAD-2.1.1 4.02E-06
32863 69 N/Y 100 rs746957606 0.7321 None gnomAD-4.0.0 2.05255E-06
32864 70 V/A 102 rs201257063 0.2020 None gnomAD-2.1.1 1.10552E-04
32864 70 V/A 102 rs201257063 0.2020 None gnomAD-3.1.2 3.29E-05
32864 70 V/A 102 rs201257063 0.2020 None gnomAD-4.0.0 1.165E-04
32864 70 V/E 102 rs201257063 0.2020 None gnomAD-3.1.2 6.57E-06
32864 70 V/E 102 rs201257063 0.2020 None gnomAD-4.0.0 6.57255E-06
32866 72 Y/C 104 None 0.0860 None gnomAD-4.0.0 1.20032E-06
32867 73 H/L 105 None 0.2487 None gnomAD-4.0.0 4.77351E-06
32869 75 R/C 107 rs186244950 0.1618 None gnomAD-2.1.1 2.14021E-04
32869 75 R/C 107 rs186244950 0.1618 None gnomAD-3.1.2 1.2489E-04
32869 75 R/C 107 rs186244950 0.1618 None 1000 genomes 1.99681E-04
32869 75 R/C 107 rs186244950 0.1618 None gnomAD-4.0.0 1.19593E-04
32869 75 R/H 107 rs587780495 0.1618 None gnomAD-2.1.1 4.64E-05
32869 75 R/H 107 rs587780495 0.1618 None gnomAD-3.1.2 5.26E-05
32869 75 R/H 107 rs587780495 0.1618 None gnomAD-4.0.0 2.78837E-05
32869 75 R/L 107 None 0.1618 None gnomAD-4.0.0 1.3684E-06
32872 78 A/E 110 None 0.0795 None gnomAD-4.0.0 6.84197E-07
32872 78 A/G 110 rs150288160 0.0795 None gnomAD-2.1.1 1.2E-05
32872 78 A/G 110 rs150288160 0.0795 None gnomAD-3.1.2 2.63E-05
32872 78 A/G 110 rs150288160 0.0795 None 1000 genomes 1.99681E-04
32872 78 A/G 110 rs150288160 0.0795 None gnomAD-4.0.0 2.35467E-05
32872 78 A/S 110 rs1326692589 0.0795 None gnomAD-2.1.1 4.02E-06
32872 78 A/S 110 rs1326692589 0.0795 None gnomAD-4.0.0 1.59122E-06
32873 79 E/K 111 rs1575354700 0.3750 None gnomAD-4.0.0 3.42099E-06
32876 82 F/C 114 rs764169875 0.5824 None gnomAD-3.1.2 6.57E-06
32876 82 F/C 114 rs764169875 0.5824 None gnomAD-4.0.0 1.23939E-06
32876 82 F/S 114 rs764169875 0.5824 None gnomAD-2.1.1 4.02E-06
32876 82 F/S 114 rs764169875 0.5824 None gnomAD-3.1.2 1.31E-05
32876 82 F/S 114 rs764169875 0.5824 None gnomAD-4.0.0 3.71817E-06
32877 83 G/R 115 None 0.2040 None gnomAD-4.0.0 1.20032E-06
32878 84 I/R 117 rs1239539070 0.4695 None gnomAD-2.1.1 7.13E-06
32878 84 I/R 117 rs1239539070 0.4695 None gnomAD-3.1.2 1.31E-05
32878 84 I/R 117 rs1239539070 0.4695 None gnomAD-4.0.0 6.81656E-06
32879 85 S/G 118 rs376395673 0.0977 None gnomAD-4.0.0 1.36842E-06
32880 86 K/R 119 None 0.8793 None gnomAD-4.0.0 1.20032E-06
32881 87 P/H 120 None 0.3361 None gnomAD-4.0.0 1.20032E-06
32881 87 P/S 120 rs367979582 0.3361 None gnomAD-2.1.1 9.99E-05
32881 87 P/S 120 rs367979582 0.3361 None gnomAD-3.1.2 7.89E-05
32881 87 P/S 120 rs367979582 0.3361 None 1000 genomes 3.99361E-04
32881 87 P/S 120 rs367979582 0.3361 None gnomAD-4.0.0 4.52369E-05
32883 89 K/T 122 rs776099498 0.5332 None gnomAD-2.1.1 4.02E-06
32883 89 K/T 122 rs776099498 0.5332 None gnomAD-4.0.0 1.59171E-06
32884 90 S/Y 123 None 0.1721 None gnomAD-4.0.0 1.20033E-06
32885 91 E/K 124 None 0.8938 None gnomAD-4.0.0 2.40064E-06
32886 92 E/A 125 None 0.6075 None gnomAD-4.0.0 6.84682E-07
32886 92 E/G 125 rs1337530273 0.6075 None gnomAD-2.1.1 8.04E-06
32886 92 E/G 125 rs1337530273 0.6075 None gnomAD-4.0.0 1.36936E-06
32886 92 E/K 125 rs767866367 0.6075 None gnomAD-2.1.1 4.02E-06
32886 92 E/K 125 rs767866367 0.6075 None gnomAD-4.0.0 1.59413E-06
32887 93 P/A 126 rs55653324 0.3165 None gnomAD-2.1.1 3.22E-05
32887 93 P/A 126 rs55653324 0.3165 None gnomAD-3.1.2 6.57E-06
32887 93 P/A 126 rs55653324 0.3165 None gnomAD-4.0.0 1.92236E-05
32887 93 P/Q 126 rs774623766 0.3165 None gnomAD-2.1.1 7.14E-06
32887 93 P/Q 126 rs774623766 0.3165 None gnomAD-4.0.0 6.84775E-07
32887 93 P/R 126 None 0.3165 None gnomAD-4.0.0 6.84775E-07
32887 93 P/S 126 None 0.3165 None gnomAD-4.0.0 1.36944E-06
32887 93 P/T 126 rs55653324 0.3165 None gnomAD-3.1.2 6.57E-06
32887 93 P/T 126 rs55653324 0.3165 None gnomAD-4.0.0 6.57272E-06
32889 95 T/A 128 rs771323245 0.3373 None gnomAD-2.1.1 7.14E-06
32889 95 T/A 128 rs771323245 0.3373 None gnomAD-3.1.2 6.57E-06
32889 95 T/A 128 rs771323245 0.3373 None gnomAD-4.0.0 2.56849E-06
32889 95 T/K 128 rs1693292110 0.3373 None gnomAD-4.0.0 1.59656E-06
32889 95 T/R 128 None 0.3373 None gnomAD-4.0.0 1.59656E-06
32891 97 K/E 131 rs768773826 0.5033 None gnomAD-4.0.0 3.19482E-06
32892 98 T/A 132 None 0.3492 None gnomAD-4.0.0 1.59916E-06