Select a Data Table to View:



Download domain sequence (FASTA)
Export SAV table to CSV

Select columns to include

Basic Information

SAV Position Domain position
RS Q(SASA) Source Structural position

Pathogenicity / Stability Predictions

AlphaMissense (IC) AlphaMissense (N2AB)
CADD Condel DUET FATHMM M-CAP
mCSM MetaLR MetaSVM MPC MutationAssessor
MutationTaster MutPred MVP PolyPhen-2
PrimateAI PROVEAN REVEL Rhapsody SIFT

Disease Associations

Disease Zygosity Comments

Population Frequencies

Whole Population MAF African (AFR) Latin American (AMR)
Amish (AMS) Ashkenazi Jewish (ASJ) East Asian (EAS)
European/1KGP (EUR) Finnish (FIN) Middle Eastern (MDE)
Non-Finnish European (NFE) South Asian (SAS) Other (OTH)

Other Annotations

Site Annotation Predicted PPI site mCSM-PPI

10 20 30 40 50 60 70 80 90
Q P A P P R R L D V V D T S K S S A V L A W L K P D H D G G S R I T G Y L L E M R Q K G S D F W V E A G H T K Q L T F T V E R L V E K T E Y E F R V K A K N D A G Y S E P R E A F S S V I I K E P Q I E P T A D L T G I T N Q L I T C K A G S P F T I D V P I S G R P A P K V T W K L E E M R L K E T D R V S I T T T K D R T T L T V K D S M R G D S G R Y F L T L E N T A G V K T F S V T V V V I
Q P A P P R R L D V V D T S K S S A V L A W L K P D H D G G S R I T G Y L L E M R Q K G S D F W V E A G H T K Q L T F T V E R L V E K T E Y E F R V K A K N D A G Y S E P R E A F S S V I I K E - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

Map SAVs to Structure

The data displayed in the table aims to be as complete as possible and contains information for all available sources including different versions of the same source, for example, different sources of gnomAD. To avoid seeing multiple entries for the same variant, we recommend to sort by Source first.

Pin SAV
Position
Domain position
SAV
Structural Position
RS
Q(SASA)
Disease
Source
MAF
31113 1 Q/H 1 None 0.5837 None gnomAD-4.0.0 1.59111E-06
31114 2 P/L 2 rs1698006505 0.1258 None gnomAD-4.0.0 4.80129E-06
31115 3 A/P 3 rs1192880016 0.1251 None gnomAD-3.1.2 6.57E-06
31115 3 A/P 3 rs1192880016 0.1251 None gnomAD-4.0.0 6.57237E-06
31115 3 A/V 3 None 0.1251 None gnomAD-4.0.0 6.84183E-07
31117 5 P/L 5 rs1185315737 0.0961 None gnomAD-2.1.1 6.37E-05
31117 5 P/L 5 rs1185315737 0.0961 None gnomAD-3.1.2 1.31E-05
31117 5 P/L 5 rs1185315737 0.0961 None gnomAD-4.0.0 5.07492E-06
31118 6 R/G 6 rs761397221 0.4122 None gnomAD-4.0.0 2.73674E-06
31118 6 R/K 6 rs763830779 0.4122 None gnomAD-2.1.1 4.03E-06
31118 6 R/K 6 rs763830779 0.4122 None gnomAD-4.0.0 1.59113E-06
31118 6 R/S 6 rs2154147269 0.4122 None gnomAD-3.1.2 6.57E-06
31118 6 R/S 6 rs2154147269 0.4122 None gnomAD-4.0.0 2.56178E-06
31119 7 R/K 7 None 0.5372 None gnomAD-4.0.0 1.20032E-06
31120 8 L/F 9 rs1698000478 0.1193 None gnomAD-4.0.0 2.05255E-06
31120 8 L/P 9 rs1310673663 0.1193 None gnomAD-2.1.1 7.15E-06
31120 8 L/P 9 rs1310673663 0.1193 None gnomAD-3.1.2 2.63E-05
31120 8 L/P 9 rs1310673663 0.1193 None gnomAD-4.0.0 8.96709E-06
31120 8 L/R 9 rs1310673663 0.1193 None gnomAD-2.1.1 4.03E-06
31120 8 L/R 9 rs1310673663 0.1193 None gnomAD-4.0.0 1.5911E-06
31120 8 L/V 9 rs1698000478 0.1193 None gnomAD-4.0.0 6.84183E-07
31121 9 D/H 11 rs1387694894 0.3426 None gnomAD-2.1.1 4.03E-06
31121 9 D/H 11 rs1387694894 0.3426 None gnomAD-4.0.0 1.59109E-06
31122 10 V/I 12 None 0.3516 None gnomAD-4.0.0 1.5911E-06
31123 11 V/I 13 rs202096200 0.5833 None gnomAD-2.1.1 4.03E-06
31123 11 V/I 13 rs202096200 0.5833 None gnomAD-4.0.0 4.78926E-06
31123 11 V/L 13 rs202096200 0.5833 None gnomAD-2.1.1 1.0364E-04
31123 11 V/L 13 rs202096200 0.5833 None gnomAD-3.1.2 3.87892E-04
31123 11 V/L 13 rs202096200 0.5833 None 1000 genomes 3.99361E-04
31123 11 V/L 13 rs202096200 0.5833 None gnomAD-4.0.0 7.62164E-05
31124 12 D/A 14 rs775147653 0.5095 None gnomAD-2.1.1 3.18E-05
31124 12 D/A 14 rs775147653 0.5095 None gnomAD-3.1.2 6.57E-06
31124 12 D/A 14 rs775147653 0.5095 None gnomAD-4.0.0 1.23937E-06
31124 12 D/V 14 rs775147653 0.5095 None gnomAD-2.1.1 1.24786E-04
31124 12 D/V 14 rs775147653 0.5095 None gnomAD-3.1.2 6.57E-06
31124 12 D/V 14 rs775147653 0.5095 None gnomAD-4.0.0 1.92102E-05
31125 13 T/S 15 None 0.2604 None gnomAD-4.0.0 2.40064E-06
31126 14 S/C 16 None 0.2360 None gnomAD-4.0.0 6.84181E-07
31126 14 S/G 16 None 0.2360 None gnomAD-4.0.0 6.84181E-07
31126 14 S/R 16 None 0.2360 None gnomAD-4.0.0 1.59112E-06
31127 15 K/R 17 rs1172489914 0.5477 None gnomAD-2.1.1 4.02E-06
31127 15 K/R 17 rs1172489914 0.5477 None gnomAD-4.0.0 1.5911E-06
31129 17 S/F 19 None 0.1977 None gnomAD-4.0.0 2.73673E-06
31130 18 A/S 20 None 0.1235 None gnomAD-4.0.0 6.84182E-07
31130 18 A/T 20 rs759107930 0.1235 None gnomAD-2.1.1 1.61E-05
31130 18 A/T 20 rs759107930 0.1235 None gnomAD-3.1.2 2.63E-05
31130 18 A/T 20 rs759107930 0.1235 None gnomAD-4.0.0 3.65627E-05
31131 19 V/G 21 rs1176407616 0.2733 None gnomAD-2.1.1 1.43E-05
31131 19 V/G 21 rs1176407616 0.2733 None gnomAD-3.1.2 2.63E-05
31131 19 V/G 21 rs1176407616 0.2733 None gnomAD-4.0.0 1.79706E-05
31131 19 V/I 21 None 0.2733 None gnomAD-4.0.0 1.20032E-06
31135 23 L/P 25 rs1284369744 0.5920 None gnomAD-2.1.1 3.19E-05
31135 23 L/P 25 rs1284369744 0.5920 None gnomAD-3.1.2 6.57E-06
31135 23 L/P 25 rs1284369744 0.5920 None gnomAD-4.0.0 2.56197E-06
31136 24 K/I 26 rs1697982034 0.6846 None gnomAD-4.0.0 1.27286E-05
31136 24 K/N 26 None 0.6846 None gnomAD-4.0.0 2.40064E-06
31137 25 P/T 27 None 0.1450 None gnomAD-4.0.0 3.42089E-06
31140 28 D/E 30 rs1697978280 0.3128 None gnomAD-4.0.0 1.59111E-06
31140 28 D/N 30 rs768116289 0.3128 None gnomAD-2.1.1 8.04E-06
31140 28 D/N 30 rs768116289 0.3128 None gnomAD-3.1.2 6.57E-06
31140 28 D/N 30 rs768116289 0.3128 None gnomAD-4.0.0 8.67559E-06
31141 29 G/E 31 rs1184196122 0.3893 None gnomAD-2.1.1 4.02E-06
31141 29 G/E 31 rs1184196122 0.3893 None gnomAD-4.0.0 1.59107E-06
31142 30 G/D 32 rs1559166976 0.7052 None gnomAD-3.1.2 6.57E-06
31142 30 G/D 32 rs1559166976 0.7052 None gnomAD-4.0.0 2.56201E-06
31143 31 S/N 33 rs749127573 0.2738 None gnomAD-2.1.1 4.02E-06
31143 31 S/N 33 rs749127573 0.2738 None gnomAD-4.0.0 1.59108E-06
31143 31 S/R 33 None 0.2738 None gnomAD-4.0.0 8.21014E-06
31144 32 R/G 34 rs770088691 0.7128 None gnomAD-2.1.1 4.02E-06
31144 32 R/G 34 rs770088691 0.7128 None gnomAD-4.0.0 4.78923E-06
31144 32 R/Q 34 rs561941986 0.7128 None gnomAD-2.1.1 1.61E-05
31144 32 R/Q 34 rs561941986 0.7128 None gnomAD-3.1.2 6.58E-06
31144 32 R/Q 34 rs561941986 0.7128 None gnomAD-4.0.0 9.91538E-06
31144 32 R/W 34 rs770088691 0.7128 None gnomAD-2.1.1 8.04E-06
31144 32 R/W 34 rs770088691 0.7128 None gnomAD-3.1.2 6.58E-06
31144 32 R/W 34 rs770088691 0.7128 None gnomAD-4.0.0 5.57738E-06
31146 34 T/I 36 None 0.3733 None gnomAD-4.0.0 1.20032E-06
31146 34 T/S 36 None 0.3733 None gnomAD-4.0.0 1.20032E-06
31147 35 G/V 37 rs1234293999 0.1575 None gnomAD-2.1.1 4.02E-06
31148 36 Y/H 38 rs373131310 0.1404 None gnomAD-2.1.1 3.93E-05
31148 36 Y/H 38 rs373131310 0.1404 None gnomAD-3.1.2 5.26E-05
31148 36 Y/H 38 rs373131310 0.1404 None gnomAD-4.0.0 8.30348E-05
31149 37 L/V 39 None 0.1814 None gnomAD-4.0.0 1.20032E-06
31150 38 L/P 40 None 0.1024 None gnomAD-4.0.0 1.59107E-06
31152 40 M/R 42 None 0.2386 None gnomAD-4.0.0 1.20041E-06
31152 40 M/V 42 None 0.2386 None gnomAD-4.0.0 1.20032E-06
31153 41 R/G 43 None 0.2103 None gnomAD-4.0.0 6.8417E-07
31153 41 R/K 43 None 0.2103 None gnomAD-4.0.0 2.40064E-06
31155 43 K/N 50 rs1351647298 0.3997 None gnomAD-2.1.1 4.02E-06
31155 43 K/N 50 rs1351647298 0.3997 None gnomAD-4.0.0 6.84177E-07
31155 43 K/R 50 rs1230714355 0.3997 None gnomAD-2.1.1 4.02E-06
31155 43 K/R 50 rs1230714355 0.3997 None gnomAD-4.0.0 1.59109E-06
31156 44 G/A 54 None 0.6929 None gnomAD-4.0.0 6.84177E-07
31156 44 G/V 54 None 0.6929 None gnomAD-4.0.0 5.47342E-06
31159 47 F/L 64 rs765476463 0.8599 None gnomAD-2.1.1 8.03E-06
31159 47 F/L 64 rs765476463 0.8599 None gnomAD-4.0.0 1.11375E-05
31159 47 F/S 64 rs1469115773 0.8599 None gnomAD-4.0.0 1.20032E-06
31159 47 F/V 64 None 0.8599 None gnomAD-4.0.0 1.59107E-06
31160 48 W/C 65 None 0.2453 None gnomAD-4.0.0 1.36835E-06
31162 50 E/A 67 rs1553529185 0.3905 None gnomAD-4.0.0 3.18211E-06
31162 50 E/K 67 rs762566802 0.3905 None gnomAD-4.0.0 1.20032E-05
31164 52 G/S 69 None 0.1501 None gnomAD-4.0.0 1.59106E-06
31164 52 G/V 69 rs1303031829 0.1501 None gnomAD-2.1.1 4.02E-06
31164 52 G/V 69 rs1303031829 0.1501 None gnomAD-4.0.0 1.59107E-06
31165 53 H/Q 70 rs752443804 0.5327 None gnomAD-2.1.1 4.02E-06
31165 53 H/Q 70 rs752443804 0.5327 None gnomAD-4.0.0 1.59107E-06
31166 54 T/A 77 rs1409419623 0.1720 None gnomAD-2.1.1 4.02E-06
31166 54 T/A 77 rs1409419623 0.1720 None gnomAD-4.0.0 1.59107E-06
31166 54 T/I 77 None 0.1720 None gnomAD-4.0.0 6.84175E-07
31166 54 T/N 77 rs767243521 0.1720 None gnomAD-2.1.1 4.02E-06
31166 54 T/N 77 rs767243521 0.1720 None gnomAD-4.0.0 2.05253E-06
31168 56 Q/H 88 None 0.6581 None gnomAD-4.0.0 1.59108E-06
31171 59 F/C 91 rs759179376 0.2255 None gnomAD-2.1.1 4.02E-06
31171 59 F/C 91 rs759179376 0.2255 None gnomAD-3.1.2 6.57E-06
31171 59 F/C 91 rs759179376 0.2255 None gnomAD-4.0.0 1.85902E-06
31171 59 F/L 91 None 0.2255 None gnomAD-4.0.0 3.18218E-06
31172 60 T/I 92 None 0.3611 None gnomAD-4.0.0 1.20032E-06
31172 60 T/R 92 None 0.3611 None gnomAD-4.0.0 1.20032E-06
31173 61 V/I 93 rs1440743167 0.1494 None gnomAD-2.1.1 4.02E-06
31174 62 E/G 94 None 0.6731 None gnomAD-4.0.0 4.80129E-06
31175 63 R/C 96 rs766346925 0.8632 None gnomAD-2.1.1 8.03E-06
31175 63 R/C 96 rs766346925 0.8632 None gnomAD-3.1.2 6.58E-06
31175 63 R/C 96 rs766346925 0.8632 None gnomAD-4.0.0 3.7182E-06
31175 63 R/H 96 rs72648251 0.8632 None gnomAD-2.1.1 4.31563E-04
31175 63 R/H 96 rs72648251 0.8632 None gnomAD-3.1.2 2.95792E-04
31175 63 R/H 96 rs72648251 0.8632 None gnomAD-4.0.0 4.41832E-04
31175 63 R/S 96 rs766346925 0.8632 None gnomAD-2.1.1 4.02E-06
31175 63 R/S 96 rs766346925 0.8632 None gnomAD-4.0.0 6.84181E-07
31176 64 L/P 97 rs773083742 0.1223 None gnomAD-2.1.1 1.43E-05
31176 64 L/P 97 rs773083742 0.1223 None gnomAD-3.1.2 3.29E-05
31176 64 L/P 97 rs773083742 0.1223 None gnomAD-4.0.0 3.28614E-05
31177 65 V/F 98 None 0.5076 None gnomAD-4.0.0 6.84177E-07
31177 65 V/I 98 rs769528066 0.5076 None gnomAD-2.1.1 8.03E-06
31179 67 K/N 100 rs776904754 0.6634 None gnomAD-2.1.1 1.2E-05
31179 67 K/N 100 rs776904754 0.6634 None gnomAD-4.0.0 4.78925E-06
31180 68 T/S 102 None 0.1953 None gnomAD-4.0.0 1.20032E-06
31181 69 E/K 103 rs1243301263 0.2104 None gnomAD-2.1.1 4.02E-06
31181 69 E/K 103 rs1243301263 0.2104 None gnomAD-4.0.0 1.59112E-06
31181 69 E/Q 103 None 0.2104 None gnomAD-4.0.0 1.59112E-06
31182 70 Y/C 104 None 0.1428 None gnomAD-4.0.0 1.59109E-06
31183 71 E/G 105 None 0.2101 None gnomAD-4.0.0 1.20032E-06
31184 72 F/V 106 None 0.1553 None gnomAD-4.0.0 8.43601E-06
31185 73 R/C 107 rs768852545 0.1213 None gnomAD-2.1.1 1.43E-05
31185 73 R/C 107 rs768852545 0.1213 None gnomAD-3.1.2 1.97E-05
31185 73 R/C 107 rs768852545 0.1213 None gnomAD-4.0.0 1.11549E-05
31185 73 R/H 107 rs771533925 0.1213 None gnomAD-2.1.1 2.81E-05
31185 73 R/H 107 rs771533925 0.1213 None gnomAD-3.1.2 3.94E-05
31185 73 R/H 107 rs771533925 0.1213 None gnomAD-4.0.0 2.16889E-05
31185 73 R/L 107 rs771533925 0.1213 None gnomAD-2.1.1 4.02E-06
31185 73 R/L 107 rs771533925 0.1213 None gnomAD-4.0.0 6.84174E-07
31187 75 K/N 109 rs1166582202 0.1851 None gnomAD-3.1.2 6.58E-06
31187 75 K/N 109 rs1166582202 0.1851 None gnomAD-4.0.0 6.57514E-06
31188 76 A/T 110 None 0.0801 None gnomAD-4.0.0 1.20032E-06
31188 76 A/V 110 None 0.0801 None gnomAD-4.0.0 1.20032E-06
31190 78 N/K 112 rs746309005 0.1229 None gnomAD-2.1.1 1.5265E-04
31190 78 N/K 112 rs746309005 0.1229 None gnomAD-3.1.2 1.51173E-04
31190 78 N/K 112 rs746309005 0.1229 None gnomAD-4.0.0 4.58556E-05
31191 79 D/E 113 rs965506398 0.7909 None gnomAD-2.1.1 8.03E-06
31191 79 D/E 113 rs965506398 0.7909 None gnomAD-4.0.0 6.36422E-06
31191 79 D/Y 113 None 0.7909 None gnomAD-4.0.0 1.20032E-06
31192 80 A/T 114 rs779450650 0.4842 None gnomAD-2.1.1 8.04E-06
31192 80 A/T 114 rs779450650 0.4842 None gnomAD-4.0.0 1.59108E-06
31193 81 G/C 115 None 0.1793 None gnomAD-4.0.0 2.05252E-06
31193 81 G/D 115 None 0.1793 None gnomAD-4.0.0 1.59109E-06
31193 81 G/V 115 rs754246638 0.1793 None gnomAD-2.1.1 4.02E-06
31193 81 G/V 115 rs754246638 0.1793 None gnomAD-4.0.0 1.59109E-06
31194 82 Y/C 117 rs543223589 0.4551 None gnomAD-2.1.1 4.64E-05
31194 82 Y/C 117 rs543223589 0.4551 None gnomAD-3.1.2 3.94E-05
31194 82 Y/C 117 rs543223589 0.4551 None 1000 genomes 1.99681E-04
31194 82 Y/C 117 rs543223589 0.4551 None gnomAD-4.0.0 2.04475E-05
31195 83 S/G 118 None 0.1015 None gnomAD-4.0.0 1.20032E-06
31195 83 S/N 118 None 0.1015 None gnomAD-4.0.0 6.84179E-07
31195 83 S/T 118 None 0.1015 None gnomAD-4.0.0 6.84179E-07
31198 86 R/G 121 rs751148256 0.3244 None gnomAD-2.1.1 1.21E-05
31198 86 R/G 121 rs751148256 0.3244 None gnomAD-4.0.0 3.18228E-06
31200 88 A/G 123 None 0.2380 None gnomAD-4.0.0 1.36839E-06
31201 89 F/L 124 rs765759269 1.1741 None gnomAD-3.1.2 6.57E-06
31201 89 F/L 124 rs765759269 1.1741 None gnomAD-4.0.0 1.23938E-06
31201 89 F/V 124 None 1.1741 None gnomAD-4.0.0 1.59118E-06
31202 90 S/F 125 rs868211733 0.5665 None gnomAD-2.1.1 4.02E-06
31202 90 S/F 125 rs868211733 0.5665 None gnomAD-3.1.2 1.97E-05
31202 90 S/F 125 rs868211733 0.5665 None gnomAD-4.0.0 1.97195E-05
31203 91 S/C 126 rs1208518110 0.2756 None gnomAD-2.1.1 8.04E-06
31203 91 S/C 126 rs1208518110 0.2756 None gnomAD-4.0.0 6.36485E-06
31203 91 S/P 126 rs1553528649 0.2756 None gnomAD-4.0.0 1.20032E-06
31204 92 V/I 127 rs750367979 0.2725 None gnomAD-2.1.1 8.04E-06
31204 92 V/I 127 rs750367979 0.2725 None gnomAD-4.0.0 3.18249E-06
31205 93 I/V 129 None 0.4766 None gnomAD-4.0.0 1.59126E-06
31206 94 I/F 130 None 0.0834 None gnomAD-4.0.0 6.84218E-07
31206 94 I/L 130 rs1020011607 0.0834 None gnomAD-4.0.0 2.05265E-06
31208 96 E/D 132 None 0.5618 None gnomAD-4.0.0 2.40064E-06
31208 96 E/K 132 rs765216493 0.5618 None gnomAD-2.1.1 4.02E-06
31208 96 E/K 132 rs765216493 0.5618 None gnomAD-4.0.0 1.59142E-06