Structural position:

  • Domain Type: Ig
  • Aligned Position: 145
  • Secondary Structure Element:
  • Secondary Structure Region:

SAVs

SAV Position (IC) Domain Position (Domain) RS
AlphaMissense (IC)
DUET
PolyPhen-2
Condel
Rhapsody
REVEL
MVP
Source
MAF
Disease
Zygosity
Site annotation
mCSM PPI
Predicted PPI site
Comments
AFR
AMR
AMS
ASJ
EAS
EUR
FIN
MDE
NFE
SAS
OTH
T/N 71 Ig-1 66 None 0.1507 None 0.996 N 0.721 0.304 0.432154444652 gnomAD-4.0.0 1.20037E-06 None None None -0.808(TCAP) N None 0 0 None 0 0 None 0 0 1.31256E-06 0 0
Y/F 167 Ig-2 64 rs1331857304 0.1071 -1.147 0.003 N 0.149 0.259 0.285698343383 gnomAD-2.1.1 3.98E-06 None None None -0.056(TCAP) N None 6.15E-05 0 None 0 0 None 0 None 0 0 0
Y/F 167 Ig-2 64 rs1331857304 0.1071 -1.147 0.003 N 0.149 0.259 0.285698343383 gnomAD-3.1.2 1.31E-05 None None None -0.056(TCAP) N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
Y/F 167 Ig-2 64 rs1331857304 0.1071 -1.147 0.003 N 0.149 0.259 0.285698343383 gnomAD-4.0.0 3.84167E-06 None None None -0.056(TCAP) N None 5.0734E-05 0 None 0 0 None 0 0 0 0 0
Y/H 167 Ig-2 64 rs1226873128 0.508 -1.343 0.991 N 0.457 0.471 0.480274617672 gnomAD-2.1.1 1.59E-05 None None None -0.095(TCAP) N None 0 1.15634E-04 None 0 0 None 0 None 0 0 0
Y/H 167 Ig-2 64 rs1226873128 0.508 -1.343 0.991 N 0.457 0.471 0.480274617672 gnomAD-3.1.2 6.57E-06 None None None -0.095(TCAP) N None 0 0 0 0 0 None 0 0 0 0 4.78469E-04
Y/H 167 Ig-2 64 rs1226873128 0.508 -1.343 0.991 N 0.457 0.471 0.480274617672 gnomAD-4.0.0 1.30108E-05 None None None -0.095(TCAP) N None 0 6.66622E-05 None 0 0 None 0 0 1.27117E-05 0 3.20082E-05
F/L 1006 Ig-3 64 None 0.9965 None 0.999 N 0.505 0.508 0.31077124679 gnomAD-4.0.0 3.60097E-06 None None None None N None 0 0 None 0 0 None 0 0 3.93751E-06 0 0
F/S 1006 Ig-3 64 None 0.9763 None 1.0 N 0.823 0.572 0.757105107938 gnomAD-4.0.0 1.59061E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43275E-05 0
F/I 1147 Ig-4 66 None 0.9195 None 0.698 N 0.446 0.446 0.456462010053 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
F/S 1147 Ig-4 66 None 0.9278 None 0.971 N 0.599 0.574 0.782198002342 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
L/I 1355 Ig-5 65 rs1561322407 0.2219 -0.405 0.811 N 0.447 0.232 0.498001352042 gnomAD-2.1.1 3.99E-06 None None None None I None 0 0 None 0 5.45E-05 None 0 None 0 0 0
L/I 1355 Ig-5 65 rs1561322407 0.2219 -0.405 0.811 N 0.447 0.232 0.498001352042 gnomAD-4.0.0 4.78882E-06 None None None None I None 2.98829E-05 0 None 0 7.56201E-05 None 0 3.46741E-04 8.99332E-07 0 0
T/I 1521 Ig-6 65 None 0.0978 None 0.012 D 0.402 0.109 0.29132392195 gnomAD-4.0.0 2.40067E-06 None None None None I None 0 0 None 0 0 None 0 0 2.62503E-06 0 0
T/P 1521 Ig-6 65 rs1574674545 0.3583 None 0.055 D 0.434 0.219 0.0806252709748 gnomAD-4.0.0 1.59124E-06 None None None None I None 0 0 None 0 0 None 0 0 0 0 3.0248E-05
Y/C 1768 Ig-8 66 rs2092250294 0.6381 None 1.0 D 0.736 0.578 0.725071404083 gnomAD-4.0.0 1.59333E-06 None None None None I None 0 2.28666E-05 None 0 0 None 0 0 0 0 0
T/S 2142 Ig-10 65 None 0.0836 None 0.946 N 0.418 0.14 0.288727942641 gnomAD-4.0.0 6.84114E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99306E-06 0 0
D/V 2237 Ig-11 64 None 0.2288 None 0.984 N 0.585 0.443 0.631027719221 gnomAD-4.0.0 1.59083E-06 None None None None N None 0 0 None 0 2.77531E-05 None 0 0 0 0 0
T/A 2418 Ig-13 63 None 0.1119 None 0.704 N 0.413 0.207 0.230578612272 gnomAD-4.0.0 1.59055E-06 None None None None N None 0 0 None 0 0 None 0 0 2.8566E-06 0 0
H/Q 2508 Ig-14 64 None 0.2053 None 0.175 N 0.235 0.07 0.137902524267 gnomAD-4.0.0 4.78873E-06 None None None None N None 0 0 None 0 0 None 0 0 0 6.9562E-05 1.65585E-05
H/R 2508 Ig-14 64 rs146970027 0.1135 0.041 0.001 N 0.146 0.141 None gnomAD-2.1.1 5.0636E-04 None None None None N None 8.01E-05 2.82E-05 None 1.93013E-04 0 None 0 None 2.11038E-03 6.13107E-04 8.31947E-04
H/R 2508 Ig-14 64 rs146970027 0.1135 0.041 0.001 N 0.146 0.141 None gnomAD-3.1.2 3.81133E-04 None None None None N None 1.44781E-04 0 0 5.76701E-04 0 None 1.60075E-03 0 4.70367E-04 0 4.77555E-04
H/R 2508 Ig-14 64 rs146970027 0.1135 0.041 0.001 N 0.146 0.141 None gnomAD-4.0.0 6.26464E-04 None None None None N None 1.06783E-04 0 None 2.02703E-04 0 None 1.99913E-03 0 7.07704E-04 0 5.44209E-04
H/Y 2508 Ig-14 64 None 0.0651 None None N 0.098 0.108 0.154104182512 gnomAD-4.0.0 2.73642E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59726E-06 0 0
M/V 2595 Ig-15 63 rs760786665 0.2686 -0.903 0.985 N 0.451 0.383 0.682569885038 gnomAD-2.1.1 2.4E-05 None None None None N None 0 0 None 0 0 None 0 None 0 5.3E-05 0
M/V 2595 Ig-15 63 rs760786665 0.2686 -0.903 0.985 N 0.451 0.383 0.682569885038 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
M/V 2595 Ig-15 63 rs760786665 0.2686 -0.903 0.985 N 0.451 0.383 0.682569885038 gnomAD-4.0.0 3.20247E-05 None None None None N None 0 0 None 0 0 None 0 0 5.7411E-05 0 2.84333E-05
K/R 2682 Ig-16 62 rs764471581 0.0833 -0.466 0.015 N 0.136 0.231 0.243972157842 gnomAD-2.1.1 3.98E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.8E-06 0
K/R 2682 Ig-16 62 rs764471581 0.0833 -0.466 0.015 N 0.136 0.231 0.243972157842 gnomAD-4.0.0 2.05226E-06 None None None None N None 0 0 None 0 0 None 0 1.73491E-04 8.993E-07 0 1.65574E-05
K/T 2682 Ig-16 62 None 0.1931 None 0.134 N 0.253 0.321 0.335661160332 gnomAD-4.0.0 6.84087E-07 None None None None N None 0 0 None 0 0 None 0 0 8.993E-07 0 0
A/V 2770 Ig-17 64 rs1329726455 0.0997 None None N 0.152 0.115 0.313518423057 gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
A/V 2770 Ig-17 64 rs1329726455 0.0997 None None N 0.152 0.115 0.313518423057 gnomAD-4.0.0 1.23906E-06 None None None None I None 0 0 None 0 0 None 0 0 1.69489E-06 0 0
S/C 2857 Ig-18 63 rs1003498795 0.0962 None 0.602 D 0.446 0.256 0.422160833541 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
S/C 2857 Ig-18 63 rs1003498795 0.0962 None 0.602 D 0.446 0.256 0.422160833541 gnomAD-4.0.0 1.23913E-06 None None None None N None 0 0 None 0 0 None 0 0 1.69489E-06 0 0
S/F 2857 Ig-18 63 rs1003498795 0.1536 None 0.602 N 0.473 0.246 0.554315986709 gnomAD-4.0.0 1.36813E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79859E-06 0 0
S/Y 2857 Ig-18 63 None 0.1673 None 0.602 D 0.473 0.306 0.59904029974 gnomAD-4.0.0 4.78845E-06 None None None None N None 0 0 None 0 0 None 0 0 5.39576E-06 1.15931E-05 0
S/R 2944 Ig-19 63 rs773424866 0.8484 -0.115 0.999 N 0.733 0.495 0.489104616352 gnomAD-2.1.1 3.99E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
S/R 2944 Ig-19 63 rs773424866 0.8484 -0.115 0.999 N 0.733 0.495 0.489104616352 gnomAD-4.0.0 6.84068E-07 None None None None N None 0 0 None 0 0 None 0 0 0 1.15931E-05 0
H/L 3031 Ig-20 63 None 0.4353 None 1.0 N 0.777 0.576 0.733802170352 gnomAD-4.0.0 1.5906E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85649E-06 0 0
R/G 3120 Ig-21 63 None 0.5037 None 0.956 N 0.587 0.483 0.682070973213 gnomAD-4.0.0 6.84078E-07 None None None None N None 0 0 None 3.82614E-05 0 None 0 0 0 0 0
R/L 3120 Ig-21 63 None 0.4567 None 0.956 N 0.567 0.459 0.671819145075 gnomAD-4.0.0 6.84078E-07 None None None None N None 0 0 None 0 2.5208E-05 None 0 0 0 0 0
R/P 3120 Ig-21 63 rs72647894 0.9718 None 0.994 D 0.678 0.522 0.63959863781 gnomAD-4.0.0 6.84078E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99298E-07 0 0
R/Q 3120 Ig-21 63 rs72647894 0.1712 0.01 0.994 N 0.563 0.266 None gnomAD-2.1.1 4.31987E-03 None None None None N None 5.60808E-04 6.21293E-04 None 1.15853E-03 0 None 4.47595E-03 None 8.84039E-03 6.11478E-03 3.46741E-03
R/Q 3120 Ig-21 63 rs72647894 0.1712 0.01 0.994 N 0.563 0.266 None gnomAD-3.1.2 3.89788E-03 None None None None N None 7.24393E-04 1.17909E-03 1.09649E-03 1.1534E-03 1.9253E-04 None 1.07385E-02 0 5.95291E-03 3.93375E-03 4.79846E-04
R/Q 3120 Ig-21 63 rs72647894 0.1712 0.01 0.994 N 0.563 0.266 None 1000 genomes 1.59744E-03 None None None None N None 8E-04 0 None None 0 2E-03 None None None 5.1E-03 None
R/Q 3120 Ig-21 63 rs72647894 0.1712 0.01 0.994 N 0.563 0.266 None gnomAD-4.0.0 3.7582E-03 None None None None N None 7.73168E-04 8.49887E-04 None 8.7826E-04 2.22955E-05 None 9.02674E-03 2.63939E-03 4.04067E-03 4.09512E-03 3.104E-03
R/W 3120 Ig-21 63 rs149492487 0.4038 -0.507 1.0 N 0.797 0.598 None gnomAD-2.1.1 3.54E-05 None None None None N None 1.20173E-04 0 None 0 0 None 1.30685E-04 None 0 2.33E-05 0
R/W 3120 Ig-21 63 rs149492487 0.4038 -0.507 1.0 N 0.797 0.598 None gnomAD-3.1.2 4.6E-05 None None None None N None 1.44844E-04 0 0 0 0 None 0 0 0 0 4.78469E-04
R/W 3120 Ig-21 63 rs149492487 0.4038 -0.507 1.0 N 0.797 0.598 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
R/W 3120 Ig-21 63 rs149492487 0.4038 -0.507 1.0 N 0.797 0.598 None gnomAD-4.0.0 1.42498E-05 None None None None N None 1.0663E-04 0 None 0 0 None 0 0 5.08476E-06 7.68673E-05 3.19969E-05
R/I 3211 Ig-22 65 rs761751013 0.2541 0.207 0.241 N 0.366 0.352 0.57985626996 gnomAD-2.1.1 1.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.64E-05 0
R/I 3211 Ig-22 65 rs761751013 0.2541 0.207 0.241 N 0.366 0.352 0.57985626996 gnomAD-4.0.0 3.181E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71308E-06 0 0
R/S 3211 Ig-22 65 rs753709846 0.4283 -0.703 0.061 N 0.245 0.3 0.18274738541 gnomAD-2.1.1 1.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.64E-05 0
R/S 3211 Ig-22 65 rs753709846 0.4283 -0.703 0.061 N 0.245 0.3 0.18274738541 gnomAD-4.0.0 3.18101E-06 None None None None N None 0 0 None 0 0 None 0 0 5.71311E-06 0 0
R/T 3211 Ig-22 65 rs761751013 0.1986 -0.378 0.002 N 0.141 0.311 0.387850303812 gnomAD-2.1.1 1.19E-05 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 1.76E-05 0
R/T 3211 Ig-22 65 rs761751013 0.1986 -0.378 0.002 N 0.141 0.311 0.387850303812 gnomAD-4.0.0 6.36199E-06 None None None None N None 0 0 None 0 0 None 0 0 8.56962E-06 1.43271E-05 0
F/L 3302 Ig-23 64 rs1382593583 0.9718 -0.774 0.999 N 0.478 0.523 0.637577279198 gnomAD-2.1.1 3.98E-06 None None None None I None 0 0 None 0 0 None 0 None 0 8.82E-06 0
Y/C 3530 Ig-25 66 None 0.1877 None None None None 0.212 None gnomAD-4.0.0 2.05276E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69859E-06 0 0
Y/F 3530 Ig-25 66 rs755931621 0.1125 -0.614 None None None 0.103 None gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
Y/F 3530 Ig-25 66 rs755931621 0.1125 -0.614 None None None 0.103 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
Y/F 3530 Ig-25 66 rs755931621 0.1125 -0.614 None None None 0.103 None gnomAD-4.0.0 2.47891E-06 None None None None N None 0 0 None 0 0 None 0 0 3.39063E-06 0 0
K/R 3883 Ig-27 64 rs764648076 0.0821 0.108 0.001 N 0.235 0.095 None gnomAD-2.1.1 2.01E-05 None None None None I None 0 1.44986E-04 None 0 0 None 0 None 0 0 0
K/R 3883 Ig-27 64 rs764648076 0.0821 0.108 0.001 N 0.235 0.095 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 6.55E-05 0 0 0 None 0 0 0 0 0
K/R 3883 Ig-27 64 rs764648076 0.0821 0.108 0.001 N 0.235 0.095 None gnomAD-4.0.0 5.57711E-06 None None None None I None 1.33469E-05 1.16717E-04 None 0 0 None 0 0 8.47588E-07 0 0
K/T 3883 Ig-27 64 rs764648076 0.1084 -0.026 None N 0.116 0.137 None gnomAD-2.1.1 3.19E-05 None None None None I None 0 0 None 0 0 None 0 None 0 6.48E-05 0
K/T 3883 Ig-27 64 rs764648076 0.1084 -0.026 None N 0.116 0.137 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
K/T 3883 Ig-27 64 rs764648076 0.1084 -0.026 None N 0.116 0.137 None gnomAD-4.0.0 6.5722E-06 None None None None I None 0 0 None 0 0 None 0 0 1.47007E-05 0 0
Q/E 4002 Ig-28 65 None 0.1116 None 0.425 N 0.269 0.176 None gnomAD-4.0.0 1.59216E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
Q/K 4763 Ig-30 64 rs1187967109 0.3073 0.227 0.679 N 0.213 0.197 0.177238962908 gnomAD-2.1.1 3.18E-05 None None None None I None 0 1.17924E-03 None 0 0 None 0 None 0 0 0
Q/L 4763 Ig-30 64 rs1574049717 0.4334 None 0.316 N 0.252 0.298 0.493896554345 gnomAD-4.0.0 1.59135E-06 None None None None I None 0 2.28655E-05 None 0 0 None 0 0 0 0 0
T/S 4858 Ig-31 64 rs2081354978 0.1118 None 0.023 N 0.121 0.071 0.251639045875 gnomAD-4.0.0 1.59116E-06 None None None None I None 0 2.28655E-05 None 0 0 None 0 0 0 0 0
K/R 4951 Ig-32 64 rs1235893686 0.0797 0.028 0.98 N 0.442 0.287 0.549671953984 gnomAD-2.1.1 4.03E-06 None None None None I None 0 0 None 0 0 None 3.28E-05 None 0 0 0
K/R 4951 Ig-32 64 rs1235893686 0.0797 0.028 0.98 N 0.442 0.287 0.549671953984 gnomAD-4.0.0 2.05335E-06 None None None None I None 0 0 None 0 0 None 0 0 8.99573E-07 2.32072E-05 0
E/A 5324 Ig-36 64 None 0.2321 None 0.977 N 0.633 0.351 0.500805711387 gnomAD-4.0.0 4.78955E-06 None None None None I None 0 0 None 0 0 None 0 0 6.29631E-06 0 0
D/N 5420 Ig-37 64 rs765827073 0.0855 -0.15 0.004 N 0.23 0.169 0.286465849087 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.61E-05 None 0 None 0 0 0
D/N 5420 Ig-37 64 rs765827073 0.0855 -0.15 0.004 N 0.23 0.169 0.286465849087 gnomAD-4.0.0 3.18391E-06 None None None None N None 0 0 None 0 2.78149E-05 None 0 0 2.85873E-06 0 0
K/N 5513 Ig-38 64 None 0.2446 None 0.018 N 0.253 0.098 0.0954503805726 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/D 5607 Ig-39 65 rs2080656904 0.0893 None None N 0.241 0.12 0.126345400529 gnomAD-4.0.0 6.36531E-06 None None None None N None 0 0 None 0 0 None 7.52955E-05 0 0 0 0
G/R 5607 Ig-39 65 rs929034760 0.1175 None 0.033 N 0.62 0.046 0.358134431457 gnomAD-4.0.0 2.40064E-06 None None None None N None 0 0 None 0 0 None 0 0 2.625E-06 0 0
G/S 5607 Ig-39 65 None 0.0636 None None N 0.121 0.112 0.0666544352282 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/K 5793 Ig-41 64 rs1287275902 0.1829 -0.403 0.006 N 0.165 0.235 0.263140351381 gnomAD-2.1.1 8.04E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 8.88E-06 0
E/K 5793 Ig-41 64 rs1287275902 0.1829 -0.403 0.006 N 0.165 0.235 0.263140351381 gnomAD-4.0.0 1.09472E-05 None None None None N None 2.98829E-05 0 None 0 0 None 0 0 1.3492E-05 0 0
E/D 5886 Ig-42 64 None 0.1113 None 0.02 N 0.178 0.146 0.220303561663 gnomAD-4.0.0 1.59168E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85894E-06 0 0
E/V 5886 Ig-42 64 None 0.2861 None 0.991 N 0.743 0.479 0.653813299475 gnomAD-4.0.0 1.59169E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85894E-06 0 0
E/D 5982 Ig-43 64 rs760854297 0.1212 -0.339 0.031 N 0.159 0.11 0.279370189704 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
E/D 5982 Ig-43 64 rs760854297 0.1212 -0.339 0.031 N 0.159 0.11 0.279370189704 gnomAD-4.0.0 1.59162E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
K/T 6075 Ig-44 64 None 0.1691 None 0.997 N 0.665 0.389 0.510230903827 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/G 6169 Ig-45 65 None 0.0796 None 0.425 N 0.375 0.3 0.492267288202 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/K 6169 Ig-45 65 None 0.0702 None 0.002 N 0.159 0.147 0.221019684889 gnomAD-4.0.0 1.59133E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85848E-06 0 0
R/T 6169 Ig-45 65 None 0.0788 None 0.642 N 0.339 0.275 0.516715673709 gnomAD-4.0.0 1.59133E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85848E-06 0 0
D/G 6262 Ig-46 64 rs757214692 0.2837 -0.515 0.003 N 0.158 0.336 0.195762928549 gnomAD-2.1.1 1.61E-05 None None None None N None 0 0 None 0 2.22792E-04 None 0 None 0 0 0
D/G 6262 Ig-46 64 rs757214692 0.2837 -0.515 0.003 N 0.158 0.336 0.195762928549 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 3.86698E-04 None 0 0 0 0 0
D/G 6262 Ig-46 64 rs757214692 0.2837 -0.515 0.003 N 0.158 0.336 0.195762928549 gnomAD-4.0.0 2.56301E-05 None None None None N None 0 0 None 0 4.8506E-04 None 0 0 0 0 0
D/H 6355 Ig-47 64 rs188878341 0.1823 -0.111 0.984 N 0.54 0.38 0.379020345274 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 3.28E-05 None 0 0 0
D/H 6355 Ig-47 64 rs188878341 0.1823 -0.111 0.984 N 0.54 0.38 0.379020345274 gnomAD-4.0.0 1.36905E-06 None None None None N None 0 0 None 0 0 None 0 0 0 2.32024E-05 0
D/Y 6355 Ig-47 64 rs188878341 0.1817 0.059 0.995 N 0.642 0.428 None gnomAD-2.1.1 2.15361E-04 None None None None N None 2.19498E-03 1.70542E-04 None 0 0 None 0 None 0 0 1.41523E-04
D/Y 6355 Ig-47 64 rs188878341 0.1817 0.059 0.995 N 0.642 0.428 None gnomAD-3.1.2 6.31114E-04 None None None None N None 2.07589E-03 5.89237E-04 0 0 0 None 0 0 0 0 4.78011E-04
D/Y 6355 Ig-47 64 rs188878341 0.1817 0.059 0.995 N 0.642 0.428 None 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
D/Y 6355 Ig-47 64 rs188878341 0.1817 0.059 0.995 N 0.642 0.428 None gnomAD-4.0.0 1.33284E-04 None None None None N None 2.54694E-03 2.67005E-04 None 0 0 None 0 0 0 0 1.28144E-04
M/I 6448 Ig-48 64 None 0.3561 None 0.468 N 0.173 0.114 0.429203605099 gnomAD-4.0.0 1.59276E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43365E-05 0
M/V 6448 Ig-48 64 rs1305903315 0.1091 None 0.159 N 0.177 0.084 0.408172294925 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
M/V 6448 Ig-48 64 rs1305903315 0.1091 None 0.159 N 0.177 0.084 0.408172294925 gnomAD-4.0.0 6.81902E-06 None None None None N None 0 0 None 0 0 None 0 0 9.3255E-06 0 0
D/G 6637 Ig-50 64 rs1240731918 0.2446 -0.302 0.015 N 0.136 0.324 0.187945064343 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
D/G 6637 Ig-50 64 rs1240731918 0.2446 -0.302 0.015 N 0.136 0.324 0.187945064343 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
D/G 6637 Ig-50 64 rs1240731918 0.2446 -0.302 0.015 N 0.136 0.324 0.187945064343 gnomAD-4.0.0 1.31546E-05 None None None None N None 4.83022E-05 0 None 0 0 None 0 0 0 0 0
D/V 6637 Ig-50 64 None 0.3872 None 0.92 N 0.399 0.421 0.57026793815 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/Y 6637 Ig-50 64 None 0.4255 None 0.996 D 0.39 0.421 0.684780014046 gnomAD-4.0.0 1.20032E-06 None None None None N None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
D/E 6824 Ig-52 64 rs1418781337 0.1 -0.308 None N 0.117 0.169 0.0666544352282 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66556E-04
D/E 6824 Ig-52 64 rs1418781337 0.1 -0.308 None N 0.117 0.169 0.0666544352282 gnomAD-4.0.0 6.84434E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29777E-06 0 4.97216E-05
D/N 6824 Ig-52 64 rs1177053668 0.107 0.078 0.018 N 0.365 0.119 0.270001397563 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 1.39509E-04 0 0
D/N 6824 Ig-52 64 rs1177053668 0.107 0.078 0.018 N 0.365 0.119 0.270001397563 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 9.42E-05 0 0 0 0
D/N 6824 Ig-52 64 rs1177053668 0.107 0.078 0.018 N 0.365 0.119 0.270001397563 gnomAD-4.0.0 7.6917E-06 None None None None N None 0 0 None 0 0 None 9.41827E-05 0 0 0 0
D/Y 6824 Ig-52 64 rs1177053668 0.3431 -0.397 0.864 N 0.487 0.241 0.473774312618 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
D/Y 6824 Ig-52 64 rs1177053668 0.3431 -0.397 0.864 N 0.487 0.241 0.473774312618 gnomAD-4.0.0 1.5925E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86049E-06 0 0
E/K 6918 Ig-53 65 None 0.1531 None 0.549 N 0.317 0.226 0.295623431141 gnomAD-4.0.0 1.59341E-06 None None None None N None 0 0 None 0 0 None 0 2.41779E-04 0 0 0
T/P 7293 Ig-57 64 rs764415612 0.2262 -0.437 0.996 D 0.367 0.484 0.486135451721 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.91E-06 0
T/P 7293 Ig-57 64 rs764415612 0.2262 -0.437 0.996 D 0.367 0.484 0.486135451721 gnomAD-4.0.0 1.3686E-06 None None None None N None 0 0 None 3.82848E-05 0 None 0 0 8.99551E-07 0 0
N/S 7386 Ig-58 64 None 0.0638 None None N 0.121 0.122 0.0482279557977 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
D/H 7482 Ig-59 64 None 0.2075 None 0.969 D 0.407 0.328 0.339074221408 gnomAD-4.0.0 1.20032E-06 None None None None I None 6.33473E-05 0 None 0 0 None 0 0 0 0 0
D/V 7482 Ig-59 64 rs558855070 0.2083 0.202 0.67 N 0.501 0.304 0.610711448424 gnomAD-2.1.1 4.04E-06 None None None None I None 6.49E-05 0 None 0 0 None 0 None 0 0 0
D/V 7482 Ig-59 64 rs558855070 0.2083 0.202 0.67 N 0.501 0.304 0.610711448424 gnomAD-3.1.2 6.58E-06 None None None None I None 2.42E-05 0 0 0 0 None 0 0 0 0 0
D/V 7482 Ig-59 64 rs558855070 0.2083 0.202 0.67 N 0.501 0.304 0.610711448424 1000 genomes 1.99681E-04 None None None None I None 8E-04 0 None None 0 0 None None None 0 None
D/V 7482 Ig-59 64 rs558855070 0.2083 0.202 0.67 N 0.501 0.304 0.610711448424 gnomAD-4.0.0 2.56379E-06 None None None None I None 1.68982E-05 0 None 0 0 None 0 2.25632E-04 0 0 0
G/R 7578 Ig-60 64 rs775145999 0.5144 -0.29 0.977 N 0.477 0.315 0.587992605178 gnomAD-2.1.1 1.21E-05 None None None None N None 0 0 None 0 0 None 0 None 0 2.67E-05 0
G/R 7578 Ig-60 64 rs775145999 0.5144 -0.29 0.977 N 0.477 0.315 0.587992605178 gnomAD-4.0.0 1.77926E-05 None None None None N None 0 0 None 0 0 None 0 0 2.33899E-05 0 0
S/C 7672 Ig-61 65 rs1470201253 0.139 None 0.998 D 0.449 0.293 0.375861065471 gnomAD-3.1.2 2.63E-05 None None None None N None 0 2.61986E-04 0 0 0 None 0 0 0 0 0
S/C 7672 Ig-61 65 rs1470201253 0.139 None 0.998 D 0.449 0.293 0.375861065471 gnomAD-4.0.0 2.62829E-05 None None None None N None 0 2.61986E-04 None 0 0 None 0 0 0 0 0
S/N 7672 Ig-61 65 None 0.0992 None None N 0.212 0.193 0.132336055621 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
E/D 7765 Ig-62 64 rs774259283 0.098 -0.356 0.001 N 0.121 0.107 0.0482279557977 gnomAD-2.1.1 7.14E-06 None None None None N None 8.27E-05 0 None 0 0 None 0 None 0 0 0
E/D 7765 Ig-62 64 rs774259283 0.098 -0.356 0.001 N 0.121 0.107 0.0482279557977 gnomAD-3.1.2 1.97E-05 None None None None N None 7.24E-05 0 0 0 0 None 0 0 0 0 0
E/D 7765 Ig-62 64 rs774259283 0.098 -0.356 0.001 N 0.121 0.107 0.0482279557977 gnomAD-4.0.0 3.09867E-06 None None None None N None 5.33988E-05 0 None 0 0 None 1.56196E-05 0 0 0 0
E/K 7952 Ig-64 64 rs752227139 0.0945 0.247 0.977 N 0.505 0.32 0.402899589544 gnomAD-2.1.1 1.79E-05 None None None None N None 4.13E-05 0 None 0 0 None 6.54E-05 None 0 1.56E-05 0
E/K 7952 Ig-64 64 rs752227139 0.0945 0.247 0.977 N 0.505 0.32 0.402899589544 gnomAD-3.1.2 4.6E-05 None None None None N None 4.83E-05 6.55E-05 0 0 0 None 0 0 4.41E-05 0 4.77555E-04
E/K 7952 Ig-64 64 rs752227139 0.0945 0.247 0.977 N 0.505 0.32 0.402899589544 gnomAD-4.0.0 4.15235E-05 None None None None N None 2.6718E-05 5.00183E-05 None 0 2.22856E-05 None 0 0 4.5773E-05 3.29417E-05 6.40471E-05
E/G 8048 Ig-65 64 None 0.0933 None 0.012 N 0.203 0.202 0.401612077098 gnomAD-4.0.0 1.59128E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85842E-06 0 0
Q/R 8141 Ig-66 64 rs2154299738 0.0733 None 0.001 N 0.197 0.132 0.0551355673512 gnomAD-4.0.0 2.40064E-06 None None None None I None 0 0 None 0 0 None 0 0 2.625E-06 0 0
T/A 8234 Ig-67 64 rs747575161 0.0995 -0.936 0.997 N 0.527 0.311 0.422040124859 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
T/A 8234 Ig-67 64 rs747575161 0.0995 -0.936 0.997 N 0.527 0.311 0.422040124859 gnomAD-4.0.0 2.73688E-06 None None None None N None 0 0 None 0 0 None 0 0 3.59796E-06 0 0
T/I 8234 Ig-67 64 rs369521909 0.373 -0.13 1.0 D 0.753 0.347 None gnomAD-2.1.1 2.41E-05 None None None None N None 6.46E-05 0 None 0 0 None 0 None 4.64E-05 3.56E-05 0
T/I 8234 Ig-67 64 rs369521909 0.373 -0.13 1.0 D 0.753 0.347 None gnomAD-3.1.2 2.63E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 4.41E-05 0 0
T/I 8234 Ig-67 64 rs369521909 0.373 -0.13 1.0 D 0.753 0.347 None gnomAD-4.0.0 2.10706E-05 None None None None N None 1.33497E-05 0 None 0 0 None 0 0 2.54294E-05 0 4.80354E-05
T/K 8234 Ig-67 64 None 0.1409 None 1.0 N 0.677 0.342 0.480724696071 gnomAD-4.0.0 6.84229E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99497E-07 0 0
D/V 8327 Ig-68 64 None 0.3324 None 0.97 N 0.437 0.41 0.647137792213 gnomAD-4.0.0 1.5914E-06 None None None None I None 0 0 None 0 2.77285E-05 None 0 0 0 0 0
G/D 8519 Ig-70 64 None 0.4872 None None N 0.339 0.203 0.144782658237 gnomAD-4.0.0 3.4215E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49783E-06 0 0
G/S 8519 Ig-70 64 rs760041371 0.0775 -0.726 None N 0.173 0.154 0.159798565429 gnomAD-2.1.1 1.61E-05 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 2.66E-05 0
G/S 8519 Ig-70 64 rs760041371 0.0775 -0.726 None N 0.173 0.154 0.159798565429 gnomAD-4.0.0 8.2116E-06 None None None None N None 0 2.23684E-05 None 0 0 None 0 0 8.99565E-06 0 1.65711E-05
G/V 8519 Ig-70 64 None 0.1692 None 0.062 N 0.591 0.143 0.296679040009 gnomAD-4.0.0 6.84301E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99565E-07 0 0
S/R 8613 Ig-71 65 None 0.1999 None 0.023 N 0.251 0.069 0.0716867268079 gnomAD-4.0.0 6.84264E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99543E-07 0 0
D/N 8706 Ig-72 64 rs377074955 0.0839 -0.121 0.785 N 0.479 0.201 None gnomAD-2.1.1 2.01E-05 None None None None N None 0 0 None 0 5.56E-05 None 0 None 0 3.56E-05 0
D/N 8706 Ig-72 64 rs377074955 0.0839 -0.121 0.785 N 0.479 0.201 None gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
D/N 8706 Ig-72 64 rs377074955 0.0839 -0.121 0.785 N 0.479 0.201 None gnomAD-4.0.0 3.9665E-05 None None None None N None 1.33536E-05 0 None 0 1.55985E-04 None 0 0 4.66239E-05 0 1.60097E-05
D/V 8706 Ig-72 64 rs763090296 0.1655 0.298 0.865 N 0.603 0.376 0.461144880706 gnomAD-2.1.1 8.04E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 3.31455E-04
D/V 8706 Ig-72 64 rs763090296 0.1655 0.298 0.865 N 0.603 0.376 0.461144880706 gnomAD-4.0.0 3.18302E-06 None None None None N None 0 4.57289E-05 None 0 0 None 0 0 0 0 0
A/V 8893 Ig-74 64 rs1353521188 0.0854 -0.303 None N 0.275 0.123 0.364730456448 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 4.65E-05 0 0
A/V 8893 Ig-74 64 rs1353521188 0.0854 -0.303 None N 0.275 0.123 0.364730456448 gnomAD-4.0.0 1.59172E-06 None None None None N None 0 0 None 0 0 None 1.88324E-05 0 0 0 0
E/D 8989 Ig-75 64 None 0.1154 None 0.002 N 0.106 0.066 0.212008924253 gnomAD-4.0.0 1.36846E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79898E-06 0 0
E/G 8989 Ig-75 64 None 0.1087 None 0.001 N 0.15 0.173 0.3571064206 gnomAD-4.0.0 1.59138E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43291E-05 0
D/G 9082 Ig-76 64 None 0.1163 None 0.042 N 0.353 0.132 0.154104182512 gnomAD-4.0.0 2.05266E-06 None None None None N None 0 0 None 0 0 None 0 0 2.6984E-06 0 0
D/H 9082 Ig-76 64 rs749836809 0.1759 -0.444 0.002 N 0.222 0.051 None gnomAD-2.1.1 1.21E-05 None None None None N None 1.93874E-04 0 None 0 0 None 0 None 0 0 0
D/H 9082 Ig-76 64 rs749836809 0.1759 -0.444 0.002 N 0.222 0.051 None gnomAD-3.1.2 2.63E-05 None None None None N None 9.65E-05 0 0 0 0 None 0 0 0 0 0
D/H 9082 Ig-76 64 rs749836809 0.1759 -0.444 0.002 N 0.222 0.051 None gnomAD-4.0.0 4.9576E-06 None None None None N None 1.06778E-04 0 None 0 0 None 0 0 0 0 0
T/R 9175 Ig-77 64 rs1438488035 0.1045 None None N 0.238 0.087 0.208000267992 gnomAD-4.0.0 9.57878E-06 None None None None N None 0 0 None 0 0 None 0 0 1.25923E-05 0 0
D/N 9268 Ig-78 64 rs751988610 0.074 -0.127 0.549 N 0.22 0.17 0.227934060464 gnomAD-2.1.1 4.02E-06 None None None None I None 0 0 None 0 5.56E-05 None 0 None 0 0 0
D/N 9268 Ig-78 64 rs751988610 0.074 -0.127 0.549 N 0.22 0.17 0.227934060464 gnomAD-4.0.0 1.59139E-06 None None None None I None 0 0 None 0 2.77254E-05 None 0 0 0 0 0
D/E 9364 Ig-79 64 rs771195179 0.1766 -0.276 0.014 None 0.148 0.145 0.0666544352282 gnomAD-2.1.1 9.55E-05 None None None None I None 2.29516E-04 0 None 0 0 None 0 None 0 0 9.2081E-04
D/E 9364 Ig-79 64 rs771195179 0.1766 -0.276 0.014 None 0.148 0.145 0.0666544352282 gnomAD-3.1.2 3.29E-05 None None None None I None 7.24E-05 1.30959E-04 0 0 0 None 0 0 0 0 0
D/E 9364 Ig-79 64 rs771195179 0.1766 -0.276 0.014 None 0.148 0.145 0.0666544352282 gnomAD-4.0.0 6.84195E-07 None None None None I None 0 2.23604E-05 None 0 0 None 0 0 0 0 0
D/H 9364 Ig-79 64 None 0.3149 None 0.901 None 0.555 0.335 0.33340067248 gnomAD-4.0.0 3.18241E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43299E-05 3.02389E-05
D/H 9460 Ig-80 64 None 0.4585 None 0.996 None 0.562 0.29 0.435915822735 gnomAD-4.0.0 1.59137E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85793E-06 0 0
G/D 9557 Ig-81 65 None 0.1411 None None None 0.147 0.145 0.197625483188 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
G/R 9557 Ig-81 65 rs1560553033 0.1491 None 0.055 None 0.437 0.121 0.342865806769 gnomAD-2.1.1 4.01E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.86E-06 0
G/R 9557 Ig-81 65 rs1560553033 0.1491 None 0.055 None 0.437 0.121 0.342865806769 gnomAD-4.0.0 3.42091E-06 None None None None N None 0 0 None 0 0 None 0 0 3.5978E-06 0 1.65645E-05
T/I 9762 Ig-83 65 rs1347223686 0.7706 0.024 0.1 None 0.307 0.235 0.389596023526 gnomAD-2.1.1 1.2E-05 None None None None I None 0 0 None 9.93E-05 5.56E-05 None 0 None 0 8.85E-06 0
T/I 9762 Ig-83 65 rs1347223686 0.7706 0.024 0.1 None 0.307 0.235 0.389596023526 gnomAD-4.0.0 2.73664E-06 None None None None I None 0 0 None 3.82673E-05 2.51915E-05 None 0 0 1.79885E-06 0 0
T/K 9762 Ig-83 65 None 0.6772 None 0.982 None 0.465 0.34 0.456919554969 gnomAD-4.0.0 1.36832E-06 None None None None I None 0 0 None 0 0 None 0 0 1.79885E-06 0 0
T/R 9762 Ig-83 65 None 0.6324 None 0.991 None 0.512 0.362 0.614442799871 gnomAD-4.0.0 6.84159E-07 None None None None I None 0 0 None 0 0 None 0 0 8.99423E-07 0 0
Q/P 9964 Ig-84 65 None 0.5981 None 0.999 None 0.467 0.587 0.52674250279 gnomAD-4.0.0 1.59238E-06 None None None None N None 0 0 None 0 0 None 1.88359E-05 0 0 0 0
R/P 10051 Ig-85 63 rs772291213 0.9876 0.005 0.957 None 0.377 0.396 0.522129480193 gnomAD-2.1.1 8.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 8.85E-06 0
R/P 10051 Ig-85 63 rs772291213 0.9876 0.005 0.957 None 0.377 0.396 0.522129480193 gnomAD-4.0.0 1.3683E-06 None None None None N None 0 0 None 0 0 None 0 0 8.99405E-07 1.15942E-05 0
R/Q 10051 Ig-85 63 None 0.2727 0.105 0.175 None 0.312 0.15 0.137902524267 gnomAD-2.1.1 1.6E-05 None None None None N None 1.93723E-04 0 None 0 0 None 3.27E-05 None 0 0 0
R/Q 10051 Ig-85 63 None 0.2727 0.105 0.175 None 0.312 0.15 0.137902524267 gnomAD-3.1.2 1.31E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
R/Q 10051 Ig-85 63 None 0.2727 0.105 0.175 None 0.312 0.15 0.137902524267 gnomAD-4.0.0 9.29475E-06 None None None None N None 4.00406E-05 0 None 0 2.22767E-05 None 0 0 8.47555E-06 1.09794E-05 0
D/E 13843 Ig-88 64 rs767535967 0.3359 -0.132 0.826 N 0.319 0.096 0.15556083564 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
D/E 13843 Ig-88 64 rs767535967 0.3359 -0.132 0.826 N 0.319 0.096 0.15556083564 gnomAD-4.0.0 1.59236E-06 None None None None N None 0 0 None 0 2.77901E-05 None 0 0 0 0 0
D/G 13843 Ig-88 64 rs1482431359 0.2513 None 0.826 N 0.277 0.139 0.19670166235 gnomAD-4.0.0 3.1847E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72069E-06 0 0
D/H 13843 Ig-88 64 None 0.583 None 0.988 N 0.361 0.247 0.258283824007 gnomAD-4.0.0 4.80129E-06 None None None None N None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
M/V 13938 Ig-89 63 rs201725483 0.1049 -0.408 None N 0.087 0.072 None gnomAD-2.1.1 3.86E-05 None None None None N None 0 0 None 0 0 None 0 None 0 8.58E-05 0
M/V 13938 Ig-89 63 rs201725483 0.1049 -0.408 None N 0.087 0.072 None gnomAD-3.1.2 4.6E-05 None None None None N None 0 0 0 0 0 None 0 0 1.02959E-04 0 0
M/V 13938 Ig-89 63 rs201725483 0.1049 -0.408 None N 0.087 0.072 None gnomAD-4.0.0 1.13639E-04 None None None None N None 1.33636E-05 0 None 0 0 None 0 0 1.48321E-04 0 1.12896E-04
Q/E 14115 Ig-91 62 rs2060169705 0.121 None None N 0.099 0.145 0.24896430686 gnomAD-4.0.0 1.5927E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86048E-06 0 0
T/P 14204 Ig-92 63 None 0.5968 None 1.0 D 0.759 0.543 0.583209036909 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 2.62501E-06 0 0
Q/E 14381 Ig-94 63 rs754568652 0.0856 0.077 0.002 N 0.124 0.112 0.128392430309 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 5.6E-05 None 0 None 0 0 0
Q/E 14381 Ig-94 63 rs754568652 0.0856 0.077 0.002 N 0.124 0.112 0.128392430309 gnomAD-4.0.0 1.59264E-06 None None None None N None 0 0 None 0 2.78071E-05 None 0 0 0 0 0
Q/L 14381 Ig-94 63 rs1433049624 0.141 0.325 0.011 N 0.403 0.124 0.192905019026 gnomAD-2.1.1 4.03E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
Q/L 14381 Ig-94 63 rs1433049624 0.141 0.325 0.011 N 0.403 0.124 0.192905019026 gnomAD-4.0.0 1.3689E-06 None None None None N None 5.98158E-05 0 None 0 0 None 0 0 0 0 0
A/P 14470 Ig-95 63 rs766505487 0.7663 -0.567 0.963 D 0.313 0.372 0.434384183301 gnomAD-2.1.1 8.06E-06 None None None None N None 0 0 None 0 0 None 0 None 0 1.78E-05 0
A/P 14470 Ig-95 63 rs766505487 0.7663 -0.567 0.963 D 0.313 0.372 0.434384183301 gnomAD-3.1.2 2.63E-05 None None None None N None 0 0 0 0 0 None 0 0 5.88E-05 0 0
A/P 14470 Ig-95 63 rs766505487 0.7663 -0.567 0.963 D 0.313 0.372 0.434384183301 gnomAD-4.0.0 2.85132E-05 None None None None N None 0 0 None 0 0 None 1.56235E-05 0 3.56063E-05 0 4.80523E-05
A/T 14470 Ig-95 63 None 0.1066 None 0.016 N 0.26 0.194 0.207176502487 gnomAD-4.0.0 6.84347E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99612E-07 0 0
S/P 14559 Ig-96 63 None 0.644 None 0.773 D 0.309 0.323 0.336647302497 gnomAD-4.0.0 1.60607E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.45645E-05 0
R/C 14737 Ig-98 63 rs748593243 0.1335 -0.171 0.999 D 0.365 0.341 0.432493127443 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 0 1.66168E-04
R/C 14737 Ig-98 63 rs748593243 0.1335 -0.171 0.999 D 0.365 0.341 0.432493127443 gnomAD-3.1.2 6.58E-06 None None None None N None 0 6.56E-05 0 0 0 None 0 0 0 0 0
R/C 14737 Ig-98 63 rs748593243 0.1335 -0.171 0.999 D 0.365 0.341 0.432493127443 gnomAD-4.0.0 6.20039E-06 None None None None N None 1.3364E-05 3.337E-05 None 0 0 None 3.12735E-05 0 4.23945E-06 0 0
R/H 14737 Ig-98 63 rs373298007 0.0788 -1.211 0.071 N 0.187 0.119 None gnomAD-2.1.1 1.39432E-04 None None None None N None 3.72116E-04 6.23866E-04 None 0 5.18E-05 None 6.55E-05 None 4E-05 3.13E-05 0
R/H 14737 Ig-98 63 rs373298007 0.0788 -1.211 0.071 N 0.187 0.119 None gnomAD-3.1.2 1.57924E-04 None None None None N None 4.58915E-04 2.62433E-04 0 0 0 None 0 0 1.47E-05 0 0
R/H 14737 Ig-98 63 rs373298007 0.0788 -1.211 0.071 N 0.187 0.119 None 1000 genomes 3.99361E-04 None None None None N None 8E-04 1.4E-03 None None 0 0 None None None 0 None
R/H 14737 Ig-98 63 rs373298007 0.0788 -1.211 0.071 N 0.187 0.119 None gnomAD-4.0.0 5.14578E-05 None None None None N None 3.33538E-04 4.50375E-04 None 0 0 None 0 0 2.03492E-05 6.59181E-05 1.60159E-05
R/L 14737 Ig-98 63 rs373298007 0.2039 0.334 0.015 N 0.272 0.172 None gnomAD-2.1.1 2.03785E-04 None None None None N None 8.27E-05 0 None 0 2.69179E-03 None 3.27E-05 None 0 7.82E-06 1.40647E-04
R/L 14737 Ig-98 63 rs373298007 0.2039 0.334 0.015 N 0.272 0.172 None gnomAD-3.1.2 1.31603E-04 None None None None N None 4.83E-05 0 0 0 3.1068E-03 None 0 0 0 2.07297E-04 4.78469E-04
R/L 14737 Ig-98 63 rs373298007 0.2039 0.334 0.015 N 0.272 0.172 None 1000 genomes 5.99042E-04 None None None None N None 0 0 None None 3E-03 0 None None None 0 None
R/L 14737 Ig-98 63 rs373298007 0.2039 0.334 0.015 N 0.272 0.172 None gnomAD-4.0.0 6.88171E-05 None None None None N None 8.00491E-05 0 None 0 2.10347E-03 None 0 0 8.47883E-07 3.29591E-05 1.12111E-04
T/A 14915 Ig-100 63 rs878854310 0.1296 None 0.201 N 0.385 0.128 0.177238962908 gnomAD-4.0.0 2.73844E-06 None None None None N None 0 0 None 3.83112E-05 0 None 0 0 2.6996E-06 0 0
T/I 14915 Ig-100 63 rs765495409 0.2683 -0.084 0.681 N 0.345 0.321 0.416454006429 gnomAD-2.1.1 1.43E-05 None None None None N None 0 0 None 0 0 None 0 None 0 3.14E-05 0
T/I 14915 Ig-100 63 rs765495409 0.2683 -0.084 0.681 N 0.345 0.321 0.416454006429 gnomAD-3.1.2 1.97E-05 None None None None N None 0 0 0 0 0 None 0 0 4.42E-05 0 0
T/I 14915 Ig-100 63 rs765495409 0.2683 -0.084 0.681 N 0.345 0.321 0.416454006429 gnomAD-4.0.0 5.58112E-06 None None None None N None 0 0 None 0 0 None 0 0 6.78432E-06 0 1.60287E-05
H/P 15093 Ig-102 63 rs1275555058 0.3037 None 0.065 D 0.471 0.278 0.342865806769 gnomAD-4.0.0 1.59382E-06 None None None None N None 0 0 None 0 2.78427E-05 None 0 0 0 0 0
H/Y 15093 Ig-102 63 None 0.1052 None 0.065 N 0.353 0.111 0.240491677333 gnomAD-4.0.0 6.84689E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99931E-07 0 0
T/A 15182 Ig-103 63 None 0.085 None 0.454 N 0.357 0.158 0.238096912614 gnomAD-4.0.0 1.59362E-06 None None None None N None 0 0 None 0 2.78847E-05 None 0 0 0 0 0
H/P 15270 Ig-104 63 None 0.4498 None 0.065 N 0.401 0.157 0.0986583533028 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
R/S 15453 Ig-106 63 rs1553714751 0.7638 None 1.0 N 0.689 0.332 0.303781844768 gnomAD-4.0.0 6.84947E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00156E-07 0 0
R/T 15453 Ig-106 63 rs1325948079 0.5968 -0.12 1.0 N 0.677 0.438 0.516827169674 gnomAD-2.1.1 4.05E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.97E-06 0
R/T 15453 Ig-106 63 rs1325948079 0.5968 -0.12 1.0 N 0.677 0.438 0.516827169674 gnomAD-4.0.0 1.59522E-06 None None None None N None 0 0 None 0 0 None 0 0 2.86517E-06 0 0
K/R 15628 Ig-108 61 rs2057772159 0.0786 None 0.193 N 0.421 0.115 0.277317399466 gnomAD-4.0.0 2.05437E-06 None None None None I None 2.99634E-05 0 None 0 0 None 0 0 8.99999E-07 0 1.65893E-05
V/A 17018 Ig-111 64 None 0.1512 None 0.001 N 0.131 0.117 0.192905019026 gnomAD-4.0.0 1.59322E-06 None None None None N None 0 2.28791E-05 None 0 0 None 0 0 0 0 0
L/F 17340 Ig-112 90 rs770603604 0.1311 -1.215 0.317 N 0.327 0.06 0.132336055621 gnomAD-2.1.1 1.01923E-04 None None None None N None 0 6.96505E-04 None 0 0 None 0 None 0 0 1.76929E-04
L/F 17340 Ig-112 90 rs770603604 0.1311 -1.215 0.317 N 0.327 0.06 0.132336055621 gnomAD-3.1.2 1.97E-05 None None None None N None 0 1.9698E-04 0 0 0 None 0 0 0 0 0
L/F 17340 Ig-112 90 rs770603604 0.1311 -1.215 0.317 N 0.327 0.06 0.132336055621 gnomAD-4.0.0 3.26908E-05 None None None None N None 0 4.00641E-04 None 0 0 None 0 0 0 0 5.81159E-05
V/A 18036 Ig-114 69 None 0.0902 None None N 0.079 0.074 0.240491677333 gnomAD-4.0.0 1.59373E-06 None None None None N None 0 0 None 0 0 None 0 0 2.863E-06 0 0
R/C 18755 Ig-116 68 rs143659933 0.1125 -0.452 0.173 N 0.351 0.237 None gnomAD-2.1.1 4.3E-05 None None None None N None 4.14E-05 5.68E-05 None 0 5.15E-05 None 3.28E-05 None 0 5.49E-05 0
R/C 18755 Ig-116 68 rs143659933 0.1125 -0.452 0.173 N 0.351 0.237 None gnomAD-3.1.2 3.95E-05 None None None None N None 4.83E-05 0 0 0 3.88048E-04 None 0 0 2.94E-05 0 0
R/C 18755 Ig-116 68 rs143659933 0.1125 -0.452 0.173 N 0.351 0.237 None gnomAD-4.0.0 1.79829E-05 None None None None N None 2.66873E-05 3.33712E-05 None 0 4.46688E-05 None 0 0 1.61123E-05 0 6.40718E-05
R/H 18755 Ig-116 68 rs772767570 0.0832 -1.173 0.995 N 0.407 0.259 0.310458034454 gnomAD-2.1.1 1.62E-05 None None None None N None 1.29534E-04 0 None 0 5.59E-05 None 0 None 0 8.92E-06 0
R/H 18755 Ig-116 68 rs772767570 0.0832 -1.173 0.995 N 0.407 0.259 0.310458034454 gnomAD-3.1.2 6.58E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
R/H 18755 Ig-116 68 rs772767570 0.0832 -1.173 0.995 N 0.407 0.259 0.310458034454 gnomAD-4.0.0 6.82281E-06 None None None None N None 5.34645E-05 0 None 0 2.23214E-05 None 0 0 1.69625E-06 4.40529E-05 0
R/L 18755 Ig-116 68 rs772767570 0.1676 None 0.929 N 0.363 0.317 0.48461828368 gnomAD-4.0.0 6.84819E-07 None None None None N None 0 0 None 0 0 None 0 0 9.00001E-07 0 0
R/S 18755 Ig-116 68 rs143659933 0.2813 -0.528 0.336 N 0.183 0.238 0.26547132957 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 5.59E-05 None 0 None 0 0 0
R/S 18755 Ig-116 68 rs143659933 0.2813 -0.528 0.336 N 0.183 0.238 0.26547132957 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 1.94024E-04 None 0 0 0 0 0
R/S 18755 Ig-116 68 rs143659933 0.2813 -0.528 0.336 N 0.183 0.238 0.26547132957 gnomAD-4.0.0 6.5741E-06 None None None None N None 0 0 None 0 1.94477E-04 None 0 0 0 0 0
A/D 19848 Ig-119 59 None 0.1931 None 0.213 N 0.429 0.198 0.373537453441 gnomAD-4.0.0 6.84324E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99594E-07 0 0
A/V 19848 Ig-119 59 rs776318202 0.0853 -0.182 0.001 N 0.129 0.069 0.245660935333 gnomAD-2.1.1 4.03E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
A/V 19848 Ig-119 59 rs776318202 0.0853 -0.182 0.001 N 0.129 0.069 0.245660935333 gnomAD-4.0.0 6.84324E-07 None None None None N None 0 2.23664E-05 None 0 0 None 0 0 0 0 0
V/G 20540 Ig-121 62 None 0.1837 None 0.324 N 0.439 0.198 0.667260656149 gnomAD-4.0.0 4.80129E-06 None None None None I None 0 0 None 0 0 None 0 0 5.25001E-06 0 0
V/I 20540 Ig-121 62 None 0.0824 None 0.001 N 0.213 0.064 0.301122078929 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
K/E 20835 Ig-122 67 rs765319119 0.3122 0.487 0.002 N 0.181 0.152 0.350746614512 gnomAD-2.1.1 8.04E-06 None None None None N None 0 5.8E-05 None 0 0 None 0 None 0 0 0
K/E 20835 Ig-122 67 rs765319119 0.3122 0.487 0.002 N 0.181 0.152 0.350746614512 gnomAD-4.0.0 1.59182E-06 None None None None N None 0 2.28739E-05 None 0 0 None 0 0 0 0 0
T/A 21237 Ig-123 61 rs766847414 0.1237 -0.54 0.962 N 0.497 0.282 0.346544149963 gnomAD-2.1.1 3.19E-05 None None None None N None 0 0 None 0 0 None 0 None 0 6.48E-05 0
T/A 21237 Ig-123 61 rs766847414 0.1237 -0.54 0.962 N 0.497 0.282 0.346544149963 gnomAD-3.1.2 1.32E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
T/A 21237 Ig-123 61 rs766847414 0.1237 -0.54 0.962 N 0.497 0.282 0.346544149963 gnomAD-4.0.0 4.34125E-06 None None None None N None 0 0 None 0 0 None 0 0 5.93555E-06 0 0
T/I 21237 Ig-123 61 None 0.3891 None 0.999 N 0.803 0.418 0.541962755691 gnomAD-4.0.0 1.20033E-06 None None None None N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0
T/N 21530 Ig-124 62 None 0.0995 None 0.188 N 0.402 0.125 0.236890367714 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/S 22325 Ig-126 61 None 0.134 None 0.919 N 0.432 0.303 0.247322355667 gnomAD-4.0.0 1.5924E-06 None None None None I None 0 0 None 0 2.77886E-05 None 0 0 0 0 0
N/K 23406 Ig-129 62 rs757600380 0.651 0.15 0.684 N 0.298 0.173 0.210429274316 gnomAD-4.0.0 1.59168E-06 None None None None I None 0 0 None 0 2.77377E-05 None 0 0 0 0 0
V/I 23697 Ig-130 61 None 0.0666 None None N 0.189 0.11 0.368554958709 gnomAD-4.0.0 1.59207E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85936E-06 0 0
T/A 24093 Ig-131 65 None 0.0702 None None N 0.135 0.089 0.0551355673512 gnomAD-4.0.0 2.40064E-06 None None None None N None 1.26695E-04 0 None 0 0 None 0 0 0 0 0
T/I 24093 Ig-131 65 rs777900528 0.1037 -0.103 None N 0.141 0.069 0.253205268125 gnomAD-2.1.1 4.03E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
T/I 24093 Ig-131 65 rs777900528 0.1037 -0.103 None N 0.141 0.069 0.253205268125 gnomAD-3.1.2 1.32E-05 None None None None N None 4.83E-05 0 0 0 0 None 0 0 0 0 0
T/I 24093 Ig-131 65 rs777900528 0.1037 -0.103 None N 0.141 0.069 0.253205268125 gnomAD-4.0.0 3.10318E-06 None None None None N None 5.34745E-05 0 None 0 0 None 0 0 8.48797E-07 0 0
V/A 25175 Ig-134 65 rs1231900798 0.1643 None None N 0.135 0.074 0.243972157842 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
V/A 25175 Ig-134 65 rs1231900798 0.1643 None None N 0.135 0.074 0.243972157842 gnomAD-4.0.0 6.5767E-06 None None None None N None 0 0 None 0 0 None 0 0 1.47102E-05 0 0
V/I 25175 Ig-134 65 rs537603113 0.0649 -0.282 None N 0.125 0.113 0.124217242631 gnomAD-2.1.1 8.05E-06 None None None None N None 0 0 None 0 0 None 6.54E-05 None 0 0 0
V/I 25175 Ig-134 65 rs537603113 0.0649 -0.282 None N 0.125 0.113 0.124217242631 gnomAD-3.1.2 6.58E-06 None None None None N None 0 0 0 0 0 None 0 0 0 2.07211E-04 0
V/I 25175 Ig-134 65 rs537603113 0.0649 -0.282 None N 0.125 0.113 0.124217242631 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 0 0 None None None 1E-03 None
V/I 25175 Ig-134 65 rs537603113 0.0649 -0.282 None N 0.125 0.113 0.124217242631 gnomAD-4.0.0 8.0573E-06 None None None None N None 1.33344E-05 0 None 0 0 None 0 0 0 1.31767E-04 0
V/L 25175 Ig-134 65 rs537603113 0.1166 -0.395 0.002 N 0.212 0.071 0.107399877778 gnomAD-2.1.1 4.03E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
V/L 25175 Ig-134 65 rs537603113 0.1166 -0.395 0.002 N 0.212 0.071 0.107399877778 gnomAD-4.0.0 2.053E-06 None None None None N None 0 0 None 0 0 None 0 0 2.69869E-06 0 0
H/L 25861 Ig-136 64 rs769029689 0.0922 None 0.012 N 0.276 0.251 0.40146981186 gnomAD-4.0.0 8.21246E-06 None None None None N None 0 2.23644E-05 None 0 0 None 0 0 8.99672E-06 0 1.65744E-05
H/P 25861 Ig-136 64 rs769029689 0.4758 0.116 0.21 N 0.382 0.272 0.337135696972 gnomAD-2.1.1 4.04E-06 None None None None N None 0 0 None 0 0 None 0 None 4.64E-05 0 0
H/P 25861 Ig-136 64 rs769029689 0.4758 0.116 0.21 N 0.382 0.272 0.337135696972 gnomAD-4.0.0 6.84377E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99679E-07 0 0
I/V 26257 Ig-137 65 rs537603440 0.0682 -0.355 0.028 N 0.205 0.188 0.432716982437 gnomAD-2.1.1 5.65E-05 None None None None I None 0 0 None 0 7.55902E-04 None 0 None 0 0 0
I/V 26257 Ig-137 65 rs537603440 0.0682 -0.355 0.028 N 0.205 0.188 0.432716982437 gnomAD-3.1.2 1.31E-05 None None None None I None 0 0 0 0 3.8625E-04 None 0 0 0 0 0
I/V 26257 Ig-137 65 rs537603440 0.0682 -0.355 0.028 N 0.205 0.188 0.432716982437 1000 genomes None None None None None I None 0 0 None None 0 0 None None None 0 None
I/V 26257 Ig-137 65 rs537603440 0.0682 -0.355 0.028 N 0.205 0.188 0.432716982437 gnomAD-4.0.0 1.12817E-05 None None None None I None 0 0 None 0 2.67893E-04 None 0 0 5.11375E-06 0 0
I/K 27340 Ig-140 63 rs371592971 0.1883 -0.144 0.879 N 0.659 0.295 0.72687828099 gnomAD-2.1.1 1.21E-05 None None None None I None 0 8.69E-05 None 0 0 None 0 None 0 0 0
I/K 27340 Ig-140 63 rs371592971 0.1883 -0.144 0.879 N 0.659 0.295 0.72687828099 gnomAD-3.1.2 3.29E-05 None None None None I None 2.41E-05 1.31079E-04 0 0 0 None 0 0 1.47E-05 0 4.78469E-04
I/K 27340 Ig-140 63 rs371592971 0.1883 -0.144 0.879 N 0.659 0.295 0.72687828099 gnomAD-4.0.0 8.67598E-06 None None None None I None 1.33494E-05 1.16702E-04 None 0 0 None 0 0 8.47642E-07 0 8.00615E-05
I/T 27340 Ig-140 63 rs371592971 0.1225 None 0.338 N 0.545 0.188 None gnomAD-3.1.2 6.57E-06 None None None None I None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 27340 Ig-140 63 rs371592971 0.1225 None 0.338 N 0.545 0.188 None gnomAD-4.0.0 4.9577E-06 None None None None I None 0 1.66717E-05 None 0 0 None 0 0 5.93349E-06 0 0
T/A 27737 Ig-141 62 rs764871079 0.154 -0.783 0.166 N 0.254 0.16 0.240491677333 gnomAD-2.1.1 1.61E-05 None None None None I None 0 0 None 0 1.68161E-04 None 0 None 0 0 1.66058E-04
T/A 27737 Ig-141 62 rs764871079 0.154 -0.783 0.166 N 0.254 0.16 0.240491677333 gnomAD-4.0.0 7.95874E-06 None None None None I None 0 0 None 0 1.11235E-04 None 0 0 0 1.43275E-05 0
T/N 27737 Ig-141 62 None 0.0602 None None N 0.136 0.125 0.238705975628 gnomAD-4.0.0 1.59178E-06 None None None None I None 0 0 None 0 0 None 0 0 2.85876E-06 0 0
I/K 28421 Ig-143 64 rs749273378 0.191 -0.492 0.667 N 0.634 0.308 0.776285685458 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
I/K 28421 Ig-143 64 rs749273378 0.191 -0.492 0.667 N 0.634 0.308 0.776285685458 gnomAD-4.0.0 1.59154E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.43283E-05 0
I/T 28421 Ig-143 64 rs749273378 0.1268 None 0.124 N 0.448 0.261 0.578844998551 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/T 28421 Ig-143 64 rs749273378 0.1268 None 0.124 N 0.448 0.261 0.578844998551 gnomAD-4.0.0 2.56253E-06 None None None None N None 0 0 None 0 0 None 0 0 2.39284E-06 0 2.84544E-05
I/V 28421 Ig-143 64 rs371356428 0.0628 -0.604 None N 0.187 0.038 None gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
I/V 28421 Ig-143 64 rs371356428 0.0628 -0.604 None N 0.187 0.038 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
I/V 28421 Ig-143 64 rs371356428 0.0628 -0.604 None N 0.187 0.038 None gnomAD-4.0.0 3.71833E-06 None None None None N None 1.33447E-05 0 None 0 4.46528E-05 None 3.1249E-05 0 8.4759E-07 0 0
N/K 28816 Ig-144 62 rs774349799 0.3251 0.146 0.324 N 0.237 0.189 0.232513804876 gnomAD-2.1.1 4.08E-06 None None None None N None 6.47E-05 0 None 0 0 None 0 None 0 0 0
N/K 28816 Ig-144 62 rs774349799 0.3251 0.146 0.324 N 0.237 0.189 0.232513804876 gnomAD-3.1.2 3.29E-05 None None None None N None 1.2068E-04 0 0 0 0 None 0 0 0 0 0
N/K 28816 Ig-144 62 rs774349799 0.3251 0.146 0.324 N 0.237 0.189 0.232513804876 gnomAD-4.0.0 3.72583E-06 None None None None N None 8.01967E-05 0 None 0 0 None 0 0 0 0 0
V/I 29108 Ig-145 64 rs1393606181 0.073 -0.339 0.014 N 0.201 0.055 0.314716216878 gnomAD-2.1.1 8.04E-06 None None None None I None 0 0 None 0 0 None 6.54E-05 None 0 0 0
V/I 29108 Ig-145 64 rs1393606181 0.073 -0.339 0.014 N 0.201 0.055 0.314716216878 gnomAD-4.0.0 1.59103E-06 None None None None I None 0 0 None 0 0 None 0 0 0 1.43271E-05 0
D/E 29504 Ig-146 61 None 0.1469 None 0.003 N 0.205 0.103 0.0716867268079 gnomAD-4.0.0 8.40227E-06 None None None None N None 0 0 None 0 0 None 0 0 9.18751E-06 0 0
D/N 29504 Ig-146 61 rs376679796 0.0546 0.136 None N 0.11 0.099 None gnomAD-2.1.1 6.78989E-04 None None None None N None 1.65317E-04 1.98267E-04 None 0 0 None 5.00033E-03 None 1.20096E-04 1.56389E-04 4.21348E-04
D/N 29504 Ig-146 61 rs376679796 0.0546 0.136 None N 0.11 0.099 None gnomAD-3.1.2 2.23464E-04 None None None None N None 1.68911E-04 6.55E-05 0 0 0 None 0 0 8.82E-05 4.14422E-03 0
D/N 29504 Ig-146 61 rs376679796 0.0546 0.136 None N 0.11 0.099 None 1000 genomes 9.98403E-04 None None None None N None 0 0 None None 0 0 None None None 5.1E-03 None
D/N 29504 Ig-146 61 rs376679796 0.0546 0.136 None N 0.11 0.099 None gnomAD-4.0.0 3.51971E-04 None None None None N None 1.99893E-04 1.83291E-04 None 0 8.92977E-05 None 2.18812E-04 8.25083E-04 7.20451E-05 4.54575E-03 3.20123E-04
D/Y 29504 Ig-146 61 None 0.1445 None 0.383 D 0.453 0.112 0.511390160789 gnomAD-4.0.0 3.42114E-06 None None None None N None 0 0 None 0 0 None 0 0 4.49722E-06 0 0
T/I 29903 Ig-147 62 rs72648240 0.388 -0.052 1.0 N 0.752 0.538 0.667016649589 gnomAD-2.1.1 8.04E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 8.88E-06 0
T/I 29903 Ig-147 62 rs72648240 0.388 -0.052 1.0 N 0.752 0.538 0.667016649589 gnomAD-3.1.2 1.31E-05 None None None None N None 0 0 0 0 0 None 0 0 2.94E-05 0 0
T/I 29903 Ig-147 62 rs72648240 0.388 -0.052 1.0 N 0.752 0.538 0.667016649589 gnomAD-4.0.0 6.81657E-06 None None None None N None 0 1.66672E-05 None 0 0 None 0 0 8.47588E-06 0 0
T/S 29903 Ig-147 62 rs72648240 0.1095 -0.409 0.999 N 0.563 0.271 0.331619326243 gnomAD-2.1.1 3.06959E-04 None None None None N None 8.27E-05 2.2627E-04 None 3.76957E-03 0 None 0 None 0 2.65513E-04 4.20875E-04
T/S 29903 Ig-147 62 rs72648240 0.1095 -0.409 0.999 N 0.563 0.271 0.331619326243 gnomAD-3.1.2 2.43117E-04 None None None None N None 4.82E-05 1.96361E-04 0 4.03458E-03 0 None 0 0 2.64574E-04 0 0
T/S 29903 Ig-147 62 rs72648240 0.1095 -0.409 0.999 N 0.563 0.271 0.331619326243 gnomAD-4.0.0 2.9931E-04 None None None None N None 6.67307E-05 2.16674E-04 None 3.24302E-03 0 None 1.56377E-05 0 2.94961E-04 0 3.20184E-04
K/R 30195 Ig-148 64 rs1699777024 0.074 None 0.001 N 0.237 0.067 0.329540904979 gnomAD-4.0.0 2.05684E-06 None None None None N None 0 0 None 0 0 None 0 0 1.80063E-06 1.17148E-05 0
T/N 30590 Ig-149 59 None 0.0769 None 0.007 N 0.179 0.097 0.27132560031 gnomAD-4.0.0 1.20032E-06 None None None None I None 0 0 None 0 0 None 0 0 1.3125E-06 0 0
N/S 30987 Ig-150 61 rs2154147602 0.0848 None 0.012 N 0.181 0.116 0.187945064343 gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 0 None 0 0 1.47E-05 0 0
N/Y 30987 Ig-150 61 None 0.2803 None 0.979 N 0.476 0.483 0.69386598177 gnomAD-4.0.0 1.08029E-05 None None None None N None 0 0 None 0 0 None 0 0 1.18125E-05 0 0
M/I 31279 Ig-151 62 rs577904312 0.3413 0.417 0.969 N 0.235 0.242 0.387850303812 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
M/I 31279 Ig-151 62 rs577904312 0.3413 0.417 0.969 N 0.235 0.242 0.387850303812 gnomAD-3.1.2 6.57E-06 None None None None N None 2.41E-05 0 0 0 0 None 0 0 0 0 0
M/I 31279 Ig-151 62 rs577904312 0.3413 0.417 0.969 N 0.235 0.242 0.387850303812 1000 genomes 1.99681E-04 None None None None N None 8E-04 0 None None 0 0 None None None 0 None
M/I 31279 Ig-151 62 rs577904312 0.3413 0.417 0.969 N 0.235 0.242 0.387850303812 gnomAD-4.0.0 6.56625E-06 None None None None N None 2.40523E-05 0 None 0 0 None 0 0 0 0 0
M/L 31279 Ig-151 62 None 0.0951 None 0.652 N 0.231 0.295 0.395143324098 gnomAD-4.0.0 6.84173E-07 None None None None N None 0 0 None 0 2.51991E-05 None 0 0 0 0 0
M/T 31279 Ig-151 62 None 0.1707 None 0.912 N 0.327 0.318 0.691401027782 gnomAD-4.0.0 1.59105E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85776E-06 0 0
M/V 31279 Ig-151 62 rs765117891 0.079 0.327 0.811 N 0.305 0.272 0.369867359543 gnomAD-2.1.1 3.18E-05 None None None None N None 1.14811E-04 0 None 0 0 None 0 None 0 0 0
M/V 31279 Ig-151 62 rs765117891 0.079 0.327 0.811 N 0.305 0.272 0.369867359543 gnomAD-3.1.2 1.31E-05 None None None None N None 2.41E-05 0 0 0 0 None 0 0 1.47E-05 0 0
M/V 31279 Ig-151 62 rs765117891 0.079 0.327 0.811 N 0.305 0.272 0.369867359543 gnomAD-4.0.0 7.43576E-06 None None None None N None 1.33444E-05 0 None 0 0 None 0 0 8.47565E-06 0 1.60097E-05
D/G 31679 Ig-152 59 None 0.2715 None 1.0 N 0.752 0.528 0.431379191433 gnomAD-4.0.0 1.20032E-06 None None None None N None 0 0 None 0 2.75482E-04 None 0 0 0 0 0
D/N 31679 Ig-152 59 rs116567963 0.1077 -0.426 1.0 N 0.724 0.368 None gnomAD-2.1.1 1.50973E-03 None None None None N None 1.68224E-02 3.39328E-04 None 0 0 None 3.27E-05 None 0 2.34E-05 0
D/N 31679 Ig-152 59 rs116567963 0.1077 -0.426 1.0 N 0.724 0.368 None gnomAD-3.1.2 4.41519E-03 None None None None N None 1.58255E-02 5.23492E-04 0 0 0 None 0 0 1.47E-05 0 3.34288E-03
D/N 31679 Ig-152 59 rs116567963 0.1077 -0.426 1.0 N 0.724 0.368 None 1000 genomes 3.99361E-03 None None None None N None 1.51E-02 0 None None 0 0 None None None 0 None
D/N 31679 Ig-152 59 rs116567963 0.1077 -0.426 1.0 N 0.724 0.368 None gnomAD-4.0.0 8.09861E-04 None None None None N None 1.60564E-02 4.3316E-04 None 0 0 None 0 3.3036E-04 5.08572E-06 3.29402E-05 1.04033E-03
N/S 32076 Ig-153 60 rs373289373 0.1117 -0.519 0.489 N 0.231 0.175 None gnomAD-2.1.1 1.78E-05 None None None None N None 2.06629E-04 0 None 0 0 None 0 None 0 0 0
N/S 32076 Ig-153 60 rs373289373 0.1117 -0.519 0.489 N 0.231 0.175 None gnomAD-3.1.2 3.29E-05 None None None None N None 1.20656E-04 0 0 0 0 None 0 0 0 0 0
N/S 32076 Ig-153 60 rs373289373 0.1117 -0.519 0.489 N 0.231 0.175 None gnomAD-4.0.0 5.57749E-06 None None None None N None 1.2016E-04 0 None 0 0 None 0 0 0 0 0
T/N 32370 Ig-154 64 rs146098114 0.1153 -0.267 1.0 N 0.779 0.298 None gnomAD-2.1.1 2.41E-05 None None None None I None 0 0 None 0 3.33927E-04 None 0 None 0 0 0
T/N 32370 Ig-154 64 rs146098114 0.1153 -0.267 1.0 N 0.779 0.298 None gnomAD-3.1.2 1.97E-05 None None None None I None 0 0 0 0 5.77812E-04 None 0 0 0 0 0
T/N 32370 Ig-154 64 rs146098114 0.1153 -0.267 1.0 N 0.779 0.298 None gnomAD-4.0.0 2.56184E-05 None None None None I None 0 0 None 0 4.84919E-04 None 0 0 0 0 0
D/Y 32766 Ig-155 59 rs727504449 0.177 -0.386 0.627 N 0.423 0.319 0.627368885312 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.89E-06 0
E/Q 33164 Ig-156 64 rs753191182 0.2229 -0.213 1.0 N 0.645 0.274 0.390220360785 gnomAD-2.1.1 1.07E-05 None None None None N None 0 2.83E-05 None 0 0 None 0 None 0 1.56E-05 0
E/Q 33164 Ig-156 64 rs753191182 0.2229 -0.213 1.0 N 0.645 0.274 0.390220360785 gnomAD-4.0.0 6.84223E-07 None None None None N None 0 2.23694E-05 None 0 0 None 0 0 0 0 0
E/D 33660 Ig-159 65 rs727503536 0.1239 None 0.002 N 0.233 0.064 0.260249123532 gnomAD-4.0.0 2.05268E-06 None None None None N None 0 0 None 0 0 None 0 0 1.79895E-06 0 1.65651E-05
E/G 33660 Ig-159 65 rs1309484886 0.3066 -1.067 0.932 N 0.436 0.49 0.56713362702 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
E/G 33660 Ig-159 65 rs1309484886 0.3066 -1.067 0.932 N 0.436 0.49 0.56713362702 gnomAD-4.0.0 6.84207E-07 None None None None N None 0 0 None 0 0 None 0 0 8.99467E-07 0 0
E/K 33660 Ig-159 65 rs1355308623 0.4966 -0.304 0.791 N 0.423 0.288 0.400613892164 gnomAD-2.1.1 4.02E-06 None None None None N None 0 2.9E-05 None 0 0 None 0 None 0 0 0
E/K 33660 Ig-159 65 rs1355308623 0.4966 -0.304 0.791 N 0.423 0.288 0.400613892164 gnomAD-4.0.0 1.59129E-06 None None None None N None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
E/Q 33660 Ig-159 65 None 0.28 None 0.174 N 0.233 0.161 0.266385636622 gnomAD-4.0.0 1.59129E-06 None None None None N None 0 2.28634E-05 None 0 0 None 0 0 0 0 0
E/V 33660 Ig-159 65 rs1309484886 0.5129 0.285 0.947 N 0.497 0.557 0.681466305809 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 0 None 0 8.9E-06 0
E/V 33660 Ig-159 65 rs1309484886 0.5129 0.285 0.947 N 0.497 0.557 0.681466305809 gnomAD-4.0.0 4.78945E-06 None None None None N None 0 0 None 0 0 None 0 0 6.29627E-06 0 0
T/I 34200 Ig-160 64 None 0.5121 None None N 0.253 0.193 0.279776271856 gnomAD-4.0.0 2.40065E-06 None None None None N None 0 0 None 0 0 None 0 0 0 1.21507E-04 0
L/S 34427 Ig-162 65 rs759702754 0.4323 -0.993 0.781 N 0.757 0.427 0.552125808554 gnomAD-2.1.1 4.02E-06 None None None None N None 0 0 None 0 0 None 3.27E-05 None 0 0 0
L/S 34427 Ig-162 65 rs759702754 0.4323 -0.993 0.781 N 0.757 0.427 0.552125808554 gnomAD-4.0.0 3.42117E-06 None None None None N None 0 0 None 0 0 None 0 0 0 5.79656E-05 0
L/V 34427 Ig-162 65 None 0.1796 None 0.201 N 0.441 0.075 0.324436698001 gnomAD-4.0.0 1.59136E-06 None None None None N None 0 0 None 0 0 None 0 0 2.85762E-06 0 0
H/L 35005 Ig-163 64 rs1405155158 0.1208 0.841 0.024 N 0.345 0.247 0.430010490656 gnomAD-2.1.1 4.02E-06 None None None None N None 6.46E-05 0 None 0 0 None 0 None 0 0 0
H/L 35005 Ig-163 64 rs1405155158 0.1208 0.841 0.024 N 0.345 0.247 0.430010490656 gnomAD-4.0.0 1.5909E-06 None None None None N None 5.65227E-05 0 None 0 0 None 0 0 0 0 0
H/Y 35005 Ig-163 64 rs116876353 0.1315 0.777 0.106 N 0.181 0.132 None gnomAD-3.1.2 6.57E-06 None None None None N None 0 0 0 0 1.92456E-04 None 0 0 0 0 0
H/Y 35005 Ig-163 64 rs116876353 0.1315 0.777 0.106 N 0.181 0.132 None 1000 genomes 1.99681E-04 None None None None N None 0 0 None None 1E-03 0 None None None 0 None
H/Y 35005 Ig-163 64 rs116876353 0.1315 0.777 0.106 N 0.181 0.132 None gnomAD-4.0.0 6.56564E-06 None None None None N None 0 0 None 0 1.92901E-04 None 0 0 0 0 0
T/I 35350 Ig-165 65 rs1688665396 0.325 None 0.029 N 0.407 0.168 0.260249123532 gnomAD-4.0.0 1.44039E-05 None None None None N None 0 0 None 0 0 None 0 0 1.57501E-05 0 0
S/N 35668 Ig-167 62 rs1687674300 0.1268 None 0.334 N 0.503 0.136 0.225215365344 gnomAD-4.0.0 3.18635E-06 None None None None N None 0 0 None 0 0 None 0 0 5.72436E-06 0 0
S/R 35668 Ig-167 62 rs779265208 0.3705 -0.4 0.781 N 0.519 0.172 0.328222422547 gnomAD-2.1.1 2.82E-05 None None None None N None 0 0 None 0 3.34485E-04 None 0 None 0 0 1.66334E-04
S/R 35668 Ig-167 62 rs779265208 0.3705 -0.4 0.781 N 0.519 0.172 0.328222422547 gnomAD-4.0.0 4.10724E-06 None None None None N None 0 0 None 0 1.26027E-04 None 0 0 0 0 1.65744E-05
Q/K 35962 Ig-169 66 None 0.0897 None None N 0.105 0.145 0.141422826196 gnomAD-4.0.0 1.20033E-06 None None None -0.827(OBSL1) -0.644(OBSCN) N None 0 0 None 0 0 None 0 0 1.31252E-06 0 0

Titin has multiple isoforms, the longest being the theoretical IC (inferred complete) isoform which contains all 363 in-frame titin exons. Here all isoform positions have been mapped onto the IC sequence, with an exception being the C-terminal of the much shorter novex-3 isoform. This contains the out of frame exon 48 which cannot be mapped to the other isoforms.